Abstract: A pump shaft for a multi-stage pump, in particular a centrifugal pump, includes a peripheral groove region for the engagement of a relief device in order to introduce a force acting in the axial direction of the pump shaft. The groove region includes a plurality of grooves which are spaced apart in the axial direction.

Abstract: A fitting arrangement for a leaf of a sliding window or door that can be moved away in parallel, includes a control unit having a mounting part for fixing on the leaf and an adjusting part which is displaceable relative to the mounting part for moving the leaf away in parallel. A movement unit is fastened to the control unit and has an energy storage device and an activation element for the energy storage device. A closure arrangement for a building opening, includes a frame, the control unit and the adjusting part. The leaf which, in a closed position, can, by means of the control unit, be brought up to the frame and be moved away from the frame in parallel, so the leaf is displaceable along a guide rail of the frame. The movement unit supports an automatic movement of the leaf along the guide rail.

Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems for using and operating electric vehicle charging stations (“EVCSs”) or electric vehicle supply equipment (“EVSE”) having a touch screen. The touch screen display device can be used, for example, to facilitate user interface with the EVCS/EVSE. The touch screen display apparatus can provide a quick and efficient means for a user to input a wide variety of information. Also disclosed herein are representative embodiments of a network communication system for EVCSs or EVSE.

Abstract: The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between A? globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject.

Abstract: The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between A? globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject.

Abstract: The invention relates to N-phenyl-2-pyrimidine-amine derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.

Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems for using and operating electric vehicle charging stations (“EVCSs”) or electric vehicle supply equipment (“EVSE”) having a touch screen. The touch screen display device can be used, for example, to facilitate user interface with the EVCS/EVSE. The touch screen display apparatus can provide a quick and efficient means for a user to input a wide variety of information. Also disclosed herein are representative embodiments of a network communication system for EVCSs or EVSE.

Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems for using and operating electric vehicle charging stations (“EVCSs”) or electric vehicle supply equipment (“EVSE”) having a touch screen. The touch screen display device can be used, for example, to facilitate user interface with the EVCS/EVSE. The touch screen display apparatus can provide a quick and efficient means for a user to input a wide variety of information. Also disclosed herein are representative embodiments of a network communication system for EVCSs or EVSE.

Abstract: The invention relates to N-phenyl-2-pyrimidine-amine derivatives derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.

Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems for using and operating electric vehicle charging stations (“EVCSs”) or electric vehicle supply equipment (“EVSE”) having a touch screen. The touch screen display device can be used, for example, to facilitate user interface with the EVCS/EVSE. The touch screen display apparatus can provide a quick and efficient means for a user to input a wide variety of information. Also disclosed herein are representative embodiments of a network communication system for EVCSs or EVSE.

Abstract: The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between A? globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject.

Abstract: The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an agonist of the P/Q type voltage-gated presynaptic calcium channel to said subject.

Abstract: The present invention provides a method for improving the bioavailability of a renin inhibitor, preferably, of a ?-amino-?-hydroxy-?-aryl-alkanoic acid derivative, which method comprises co-administering to a mammal, especially a human, in need of such treatment, a combination of a renin inhibitor, or a pharmaceutically acceptable salt thereof, and an MDR1 inhibitor selected from a non-pharmacologically active compound.

Abstract: The invention relates to N-phenyl-2-pyrimidine-amine derivatives derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.

Abstract: This invention is directed to methods, nucleic acids and compositions in TAK1-mediated regulation of SMAD activity. Promotion of TAK1 interaction with MH2 domains in SMADs negatively regulates SMAD biological activity. BMP-mediated SMAD activity is subject to TAK1 effects.

Abstract: The present invention provides a method for improving the bioavailability of a renin inhibitor, preferably, of a ?-amino-?-hydroxy-?-aryl-alkanoic acid derivative, which method comprises co-administering to a mammal, especially a human, in need of such treatment, a combination of a renin inhibitor, or a pharmaceutically acceptable salt thereof, and an efflux protein inhibitor.

Abstract: The method for cooling a liquid (2) in which a coolant comprising a refrigeration-liquefied gas is introduced into the liquid (2) and the corresponding device (1) make possible, in an advantageously simple manner, the production of cooled liquids (2), which, for example, can be used as process water in the production of freshly mixed concrete. In this case the enthalpy content of the coolant, preferably of liquid nitrogen, is utilized in a good manner, by firstly using the vaporization enthalpy, and secondly the heating of the nitrogen after vaporization up to ice temperature, for cooling the liquid.

Abstract: The invention provides a method for improving the bioavailability, preferably, oral bioavailability and/or drug disposition, e.g. brain penetration, of an iron chelator, which method comprises co-administering to a mammal, especially a human, in need of such treatment, a combination of an iron chelator and an efflux protein inhibitor.

Abstract: The invention relates to N-phenyl-2-pyrimidine-amine derivatives derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.

Abstract: The invention relates to N-phenyl-2-pyrimidine-amine derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.