Abstract: This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.

Abstract: The invention relates to a method of treating a warm-blooded animal having a solid tumor disease comprising administering a combination which comprises (a) a N-phenyl-2-pyrimidine-amine derivative, especially N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.

Abstract: The invention provides a method for improving the bioavailability, preferably, oral bioavailability and/or drug disposition, e.g. brain penetration, of an iron chelator, which method comprises co-administering to a mammal, especially a human, in need of such treatment, a combination of an iron chelator and an efflux protein inhibitor.

Abstract: The present invention provides a method for improving the bioavailability of a renin inhibitor, preferably, of a ?-amino-?-hydroxy-?-aryl-alkanoic acid derivative, which method comprises co-administering to a mammal, especially a human, in need of such treatment, a combination of a renin inhibitor, or a pharmaceutically acceptable salt thereof, and an efflux protein inhibitor.

Abstract: This invention is directed to methods, nucleic acids and compositions in TAK1-mediated regulation of SMAD activity. Promotion of TAK1 interaction with MH2 domains in SMADs negatively regulates SMAD biological activity. BMP-mediated SMAD activity is subject to TAK1 effects.

Abstract: A sintered slide bearing for a shaft of an electrical machine has a bore for the shaft and also has capillary gaps. It is saturated with a lubricant. The surface region of the bore has zones of different density, which are saturated with a low-viscosity poly-alpha-olefin lubricant. As a result, positive values are established for the long-term performance and cold noises in an arbitrary installed position.

Abstract: The invention relates to novel ?-amino-?-hydroxy-?-aryl-alkanoic acid amides of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to the use of dopamine D3 receptor ligands for the production of drugs for treating renal function disorders.

Abstract: Dopamine D3 receptor ligands or antagonists are disclosed for use in the treatment of renal function disorders, such as diabetic nephropathy.

Abstract: A device (10) for mounting an electric motor (18), in particular a fan motor, includes an essentially pot-shaped receptacle housing (12)—functioning as motor housing (32)—with a receiving opening (14) into which at least part of the electric motor (18) extends. A holding flange (34) is attached to the receptacle housing (12) for mounting the motor housing (32) to a carrier element (36), e.g., a motor vehicle heater system and/or air conditioner. A mechanism for immobilizing the electric motor (18) radially and axially in the motor housing (32) is included. The receptacle housing (12) includes at least one resilient-elastic holding element (50, 52, 90) for axial immobilization.

Abstract: A method for determining bandwidth capacity of a test segment by sending one or more short packet bursts or streams from unique source smart nodes (SNs) over a link, which has the test segment, to one or more destination SNs. Selected source SNs send packet bursts or streams to other selected SNs at precise times so that the packet bursts or streams traverse the test segment simultaneously. Analyses of the traffic flow patterns at the destination SNs, including byte count measurements and time stamps, are used to determine the bandwidth capacity of the test segment.

Abstract: An overload protection for electric motors, includes a one-piece suppression choke in which the connecting point to be broken is produced by means of at least one connecting point between the connection lug of the motor and a respective connecting element of the suppression choke, wherein the connection lug exerts an adjustable mechanical stress on the connecting point, thus reliably assuring a break when the softening temperature of the solder of the breaking point is reached.

Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell, which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector, which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition-comprising cell that expresses a factor of the T-box family, which includes inter-alia the brachyury.

Abstract: An arrangement is provided for measuring jitter between an initiating network end point and a receiving network end point. A plurality of source packets are sent from the initiating network end point with pre-determined source spacing between any two adjacent source packets to the receiving network end point At the receiving network end point, at least some of the source packets are received with a plurality of destination spacing between pairs of adjacent received packets. A jitter estimation mechanism determines the jitter between the two network end points based on the source spacing and the destination spacing.

Abstract: The invention relates to N-phenyl-2-pyrimidine-amine derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.

Abstract: The invention relates to a recombinant human cell of undifferentiated mesenchyma for bone and cartilage cell formation, the human cell having the ability to express Tbr-1, Brachyury or another member of the T-box family.

Abstract: According to a conventional method for incinerating organic waste material, a fluidization device causes an oxygenous fluidizing gas to flow through the waste material, which is located in an incineration chamber, from underneath while forming a fluidized particle layer and the waste material is incinerated. The resulting flue gas is withdrawn via an open space situated above the particle layer and is subjected to a secondary incineration in a secondary reaction zone or secondary incineration chamber. Expanding upon the prior art, the aim of the invention is enable a high throughput for the incineration material while resulting in a low level of nitrogen oxide production, and to increase the productivity for the incineration of organic waste material. To these ends, the invention provides that the fluidized particle layer (3) is concentrated with oxygen in such a manner that a mean oxygen content ranging from 0-3 vol. % is set in the open space (6).

Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.

Abstract: The starting point is a process to improve the performance of the incineration of combustible waste material in an incineration chamber, whereby the waste material is conveyed to a burner flame where it is burned with combustion air at a temperature in the range from 1100° C. to 1700° C. [2012° F. to 3092° F.]. On this basis, in order to create a process that allows a capacity increase of installations employed for the exothermal incineration of waste materials, it is proposed according to the invention that at least part of the combustion air is replaced by an oxygen-rich gas having an oxygen content that is higher than that of air and that the oxygen-rich gas is mixed with a cooling medium.

Abstract: In a process for producing elemental sulfur by combustion of hydrogen sulfide or a hydrogen-sulfide-containing gas, in particular a Claus process, the hydrogen sulfide or the hydrogen-sulfide-containing gas undergoes partial combustion by using a first device in the form of a burner to which usually air is added as an oxidizing agent and which is connected to the combustion chamber. The hydrogen sulfide or the hydrogen-sulfide-containing gas undergoes further combustion by means of a second device in form of at least one nozzle which is also connected to the combustion chamber and through which oxygen or an oxygen containing gas is fed into the combustion chamber, as a result of which the hydrogen sulfide or the hydrogen-sulfide-containing gas is subjected to afterburning and is then fed to a waste-heat boiler and thereafter to one or more reactors.