Abstract: Pressing jaws for opposite arrangement in crimping pliers, the pressing jaws having ribs, which extend in a rib longitudinal direction and move into each other during pressing. A guide surface extending transversely to the rib longitudinal direction outside of a working region of the ribs is formed, which guide surface interacts with a guide protrusion extending from the opposite pressing jaw. In another version, the pressing jaws have ribs, which are designed to mesh with each other and which have a rib longitudinal direction. Crimping pliers comprise two plier jaws, which are provided with oppositely arranged pressing jaws having ribs, which extend in a rib longitudinal direction and which, during pressing, move into each other and delimit a pressing jaw opening.

Abstract: A pair of crimping pliers for crimping, in particular for crimp joining, workpieces, has two oppositely arranged pressing jaws and two pliers jaws, wherein one pliers jaw is stationary and the associated pressing jaw is fastened to this stationary pliers jaw by means of a spring-loadable holder part. The holder part is fixedly connected at its end farthest from the pressing jaw to the pliers jaw. Between the stationary connection and the end of the holder part closest to the first pressing jaw, a stop connection is formed between the stationary pliers jaw and the holder part and comes into effect when a predetermined pressing force is exceeded.

Abstract: An insulation-stripping tool designed as a hand tool for stripping insulation from a cable has a first insulation-stripping cutter for stripping the insulation transversely to a longitudinal direction of the cable and a second insulation-stripping cutter for stripping the insulation in the longitudinal direction of the cable.

Abstract: A feed and ignition device for a gas engine has an injector for the direct blowing-in of a combustion gas into a combustion chamber of the gas engine. The device also has a pre-combustion chamber into which a fuel can be introduced and a plurality of overflow openings distributed in the peripheral direction of the injector over the periphery of the feed and ignition device via which the pre-combustion chamber can be directly connected fluidically to the combustion chamber. A spark ignition device ignites a fuel-air mixture including at least the fuel introduced into the pre-combustion chamber. The pre-combustion chamber, the overflow openings, and the spark ignition device are formed by a first structural unit and the injector is formed by a second structural unit formed separately from the first structural unit.

Abstract: Pressing jaws for opposite arrangement in crimping pliers, the pressing jaws having ribs, which extend in a rib longitudinal direction and move into each other during pressing. A guide surface extending transversely to the rib longitudinal direction outside of a working region of the ribs is formed, which guide surface interacts with a guide protrusion extending from the opposite pressing jaw. In another version, the pressing jaws have ribs, which are designed to mesh with each other and which have a rib longitudinal direction. Crimping pliers comprise two plier jaws, which are provided with oppositely arranged pressing jaws having ribs, which extend in a rib longitudinal direction and which, during pressing, move into each other and delimit a pressing jaw opening.

Abstract: Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemperal dementia (FTD).

Abstract: Coated pigments for plastics, as well as processes for production of the pigments, the use thereof for colouring polyvinyl chloride (PVC), processes for colouring PVC, PVC coloured with such coated pigments, and also plastics products including such coated pigments, may include inorganic pigments coated with of at least one of hydroxides of magnesium, hydroxides of calcium, oxides of magnesium, and oxides of calcium.

Abstract: A feed and ignition device for a gas engine has an injector for the direct blowing-in of a combustion gas into a combustion chamber of the gas engine. The device also has a pre-combustion chamberto which a fuel can be introduced and a plurality of overflow openings distributed in the peripheral direction of the injector over the periphery of the feed and ignition device via which the pre-combustion chamber can be directly connected fluidically to the combustion chamber. A spark ignition device ignites a fuel-air mixture including at least the fuel introduced into the pre-combustion chamber. The pre-combustion chamber, the overflow openings, and the spark ignition device are formed by a first structural unit and the injector is formed by a second structural unit formed separately from the first structural unit.

Abstract: A pair of crimping pliers for crimping, in particular for crimp joining, workpieces, has two oppositely arranged pressing jaws and two pliers jaws, wherein one pliers jaw is stationary and the associated pressing jaw is fastened to this stationary pliers jaw by means of a spring-loadable holder part. The holder part is fixedly connected at its end farthest from the pressing jaw to the pliers jaw. Between the stationary connection and the end of the holder part closest to the first pressing jaw, a stop connection is formed between the stationary pliers jaw and the holder part and comes into effect when a predetermined pressing force is exceeded.

Abstract: The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of ?7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Abstract: (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide has been found to have procognitive effects in humans at unexpectedly low doses. Thus, (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof can be used at unexpectedly low doses to improve cognition.

Abstract: A method of administering an effective amount of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, or a pharmaceutically acceptable salt thereof, to a patient in need thereof.

Abstract: The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of ?7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Abstract: The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Abstract: A method of administering an effective amount of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, or a pharmaceutically acceptable salt thereof, to a patient in need thereof.

Abstract: The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Abstract: Coated pigments for plastics, as well as processes for production of the pigments, the use thereof for colouring polyvinyl chloride (PVC), processes for colouring PVC, PVC coloured with such coated pigments, and also plastics products including such coated pigments, may include inorganic pigments coated with of at least one of hydroxides of magnesium, hydroxides of calcium, oxides of magnesium, and oxides of calcium.

Abstract: (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide has been found to have procognitive effects in humans at unexpectedly low doses. Thus, (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof can be used at unexpectedly low doses to improve cognition.

Abstract: A method of administering an effective amount of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, or a pharmaceutically acceptable salt thereof, to a patient in need thereof.

Abstract: A method for improving cognition comprising administering to a patient (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide or a pharmaceutically acceptable salt thereof and an acetylcholinesterase inhibitor is described together with related compositions.