Patents by Inventor Gideon Baum
Gideon Baum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9844354Abstract: An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected from a comparison between at least two images acquired with the apparatus. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.Type: GrantFiled: February 6, 2008Date of Patent: December 19, 2017Assignee: CHECK-CAP LTD.Inventors: Yoav Kimchy, Yitzak Klein, Gideon Baum, Rafi Sommer
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Patent number: 9392961Abstract: An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.Type: GrantFiled: June 29, 2010Date of Patent: July 19, 2016Assignee: CHECK-CAP LTD.Inventors: Yoav Kimchy, Yitzak Klein, Gideon Baum, Rafi Sommer
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Publication number: 20160095907Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: November 11, 2015Publication date: April 7, 2016Applicant: PROTALIX LTD.Inventors: Yoseph SHAALTIEL, Gideon BAUM, Daniel BARTFELD, Sharon HASHMUELI, Ayala LEWKOWICZ
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Patent number: 9220737Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: June 2, 2014Date of Patent: December 29, 2015Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 9037219Abstract: A method of estimating distances in a colon of a subject, including: orally administering to a subject a contrast agent, orally administering an imaging capsule to the subject, emitting radiation from the imaging capsule at a location in the colon, detecting photons that are returned from an interaction of the radiation with an inner wall of the colon and contents of the colon, summating the detected photons with energies corresponding to X-ray fluorescence interactions to form a first count, summating the detected photons with energies corresponding to Compton back-scattering interactions to form a second count, determining the distance from the imaging capsule to the inner wall of the colon and a concentration of the contrast agent at the location of the imaging capsule in the colon using the values of the first count and the second count.Type: GrantFiled: September 22, 2011Date of Patent: May 19, 2015Assignee: CHECK-CAP LTD.Inventors: Gideon Baum, Yoav Kimchy
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Publication number: 20140271577Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: June 2, 2014Publication date: September 18, 2014Applicant: Protalix Ltd.Inventors: Yoseph SHAALTIEL, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8790641Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 23, 2009Date of Patent: July 29, 2014Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8741620Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: July 23, 2012Date of Patent: June 3, 2014Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20130197360Abstract: A method of estimating distances in a colon of a subject, including: orally administering to a subject a contrast agent, orally administering an imaging capsule to the subject, emitting radiation from the imaging capsule at a location in the colon, detecting photons that are returned from an interaction of the radiation with an inner wall of the colon and contents of the colon, summating the detected photons with energies corresponding to X-ray florescence interactions to form a first count, summating the detected photons with energies corresponding to Compton back-scattering interactions to form a second count, determining the distance from the imaging capsule to the inner wall of the colon and a concentration of the contrast agent at the location of the imaging capsule in the colon using the values of the first count and the second count.Type: ApplicationFiled: September 22, 2011Publication date: August 1, 2013Applicant: CHECK-CAP LTD.Inventors: Gideon Baum, Yoav Kimchy
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Patent number: 8449876Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 6, 2011Date of Patent: May 28, 2013Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8401611Abstract: A device and method for imaging body tissue, the device comprising a catheter for accessing body cavities having a catheter end, the catheter end having there within an ionizing radiation source for emitting ionizing radiation; and at least one ionizing radiation detector for detecting ionizing radiation; and wherein preferably a signal is emitted by the ionizing radiation source, said signal comprising photons or electrons, said photons or electrons are reflected from the body tissue or provoke the body tissue to generate photons or electrons.Type: GrantFiled: June 4, 2008Date of Patent: March 19, 2013Assignee: Check-Cap Ltd.Inventors: Yoav Kimchy, Gideon Baum
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Publication number: 20120282231Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: July 23, 2012Publication date: November 8, 2012Applicant: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8227230Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 6, 2011Date of Patent: July 24, 2012Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8119406Abstract: A system and method for production of antibodies in plant cell culture, which results in highly functional antibodies, produced with a high level of expression efficiency. The present invention also encompasses host cells, vectors and methods for mass production of full size assembled immunoglobulins.Type: GrantFiled: October 11, 2005Date of Patent: February 21, 2012Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Sharon Hashmueli, Daniel Bartfeld, Gideon Baum, Tal Ratz, Einat Mizrachi, Yehava Forester
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Publication number: 20110250181Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 6, 2011Publication date: October 13, 2011Applicant: Protalix Ltd.Inventors: Yoseph SHAALTIEL, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20110182868Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 6, 2011Publication date: July 28, 2011Applicant: Protalix Ltd.Inventors: Yoseph SHAALTIEL, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 7951557Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 30, 2007Date of Patent: May 31, 2011Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20110077505Abstract: A device and method for imaging body tissue, the device comprising a catheter for accessing body cavities having a catheter end, the catheter end having there within an ionizing radiation source for emitting ionizing radiation; and at least one ionizing radiation detector for detecting ionizing radiation; and wherein preferably a signal is emitted by the ionizing radiation source, said signal comprising photons or electrons, said photons or electrons are reflected from the body tissue or provoke the body tissue to generate photons or electrons.Type: ApplicationFiled: June 4, 2008Publication date: March 31, 2011Inventors: Yoav Kimchy, Gideon Baum
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Publication number: 20100303200Abstract: An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.Type: ApplicationFiled: June 29, 2010Publication date: December 2, 2010Applicant: CHECK CAP LTD.Inventors: Yoav Kimchy, Yitzak Klein, Gideon Baum, Rafi Sommer
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Publication number: 20100196345Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 30, 2008Publication date: August 5, 2010Applicant: ProtalixInventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz