Patent number: 7807685
Abstract: Compounds of formula (I) below are disclosed. Their use as medicaments is described, in particular for the treatment of pain or inflammation: wherein: when X=Y=Z=OH, R1 is OCH2CF2CF3, phenoxy (substituted with 3-(4-trifluoromethylphenyl), 3,4-dichloro, (3-trifluoromethyl,4-fluoro), (3-trifluoromethyl,4-chloro), (3-chloro, 4-cyano), or 3,5-bis(trifluoromethyl)), 1-piperazinyl(4-(3,4-dichlorophenyl)), phenyl (substituted with 3,4-dichloro, 3,5-difluoro, 3,5-bis(trifluoromethyl) or 3,4,5-trifluoro) or 2-benzofuranyl; or when X=Y=OH and Z=OMe, R1 is OCH3, OCH2CHF2, OCH2cyclopentyl, O-(2,5-difluorophenyl) or (S)-sec-butylamino; or when X=H and Y=Z=OH, R1 is n-hexylamino or cyclopentylamino; or when (IV) X=Z=OH and Y=H, R1 is cyclopentylamino; or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
June 26, 2007
Date of Patent:
October 5, 2010
Assignee:
CBT Development Limited
Inventors:
Michael Higginbottom, Edward D. Savory, Giles A. Brown, Viet-Anh A. Horgan, Emma J. Chapman
Publication number: 20080221060
Abstract: Use of compounds of general formula (A) as medicaments is described, in particular for the treatment of pain or inflammation; wherein: (I) when X=OH, R2=NH2, R5=CH2OH, R6=H, R1 is C5-C6 alkoxy, OCH2Cyclopropyl, O-(2,2,3,3-tetrafluoro-cycloButyl), phenoxy, substituted phenoxy, OCH2CH2OH, or OCH2CHF2, (5-indanyl)oxy, C1, C2, C5, or C6 alkylamino, (R) or (S)-sec-Butylamino, C5 or C6 cycloalkylamino, exo-norbornane amino, (N-methyl, N-isoamylamino), phenylamino, phenylamino with either methoxy or fluoro substituents, a C2 sulfone group, a C2 alkyl group, a cyano group, a CONH2 group, or 3,5-dimethylphenyl; or when X=H, R2=NH2, R5=CH2OH, R6=H, R1 is n-hexyloxy; or (II) when X=OH, R1=H, R5=CH2OH, R6=H, R2 is NMe2, N-(2-isopentenyl), piperazinyl, (N-Me, N-benzyl), (N-Me, N—CH2Ph(3-Br)), (N-Me, N—CH2Ph(3-CF3)), or (N-Me, N-(2-methoxyethyl)), or OCH2Cyclopentyl; or (III) when X=OH, R5=CONHR3, R6=H: R1 is H, R3 is an isopropyl group, and R2 is either NH2 or a methylamino group (NHMe) or an isoamyl group (CH2CH2CHMe2);
Type:
Application
Filed:
March 4, 2005
Publication date:
September 11, 2008
Inventors:
Martyn Pritchard, Jacqueline Ouzman, Edward Savory, Giles Brown
Publication number: 20080076776
Abstract: Compounds of formula (I) below are disclosed. Their use as medicaments is described, in particular for the treatment of pain or inflammation: wherein: when X?Y=Z=OH, R1 is OCH2CF2CF3, phenoxy (substituted with 3-(4-trifluoromethylphenyl), 3,4-dichloro, (3-trifluoromethyl,4-fluoro), (3-trifluoromethyl,4-chloro), (3-chloro, 4-cyano), or 3,5-bis(trifluoromethyl)), 1-piperazinyl(4-(3,4-dichlorophenyl)), phenyl (substituted with 3,4-dichloro, 3,5-difluoro, 3,5-bis(trifluoromethyl) or 3,4,5-trifluoro) or 2-benzofuranyl; or when X?Y?OH and Z=OMe, R1 is OCH3, OCH2CHF2, OCH2cyclopentyl, O-(2,5-difluorophenyl) or (S)-sec-butylamino; or when X?H and Y=Z=OH, R1 is n-hexylamino or cyclopentylamino; or when (IV) X=Z=OH and Y?H, R1 is cyclopentylamino; or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
June 26, 2007
Publication date:
March 27, 2008
Applicant:
BIOVITRUM AB
Inventors:
Michael Higginbottom, Edward Savory, Giles Brown, Viet-Anh Horgan, Emma Chapman