Patents by Inventor Gilles Zambardi
Gilles Zambardi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220403441Abstract: A process for determining the sensitivity or resistance of at least one identified bacterium to at least one antibiotic, wherein the process includes the following steps: a) bringing a sample including bacterium into contact with the at least one antibiotic, the antibiotic inducing the rupture of the bacterial wall and/or of the cytoplasmic membrane and causing the release of the intracellular compounds of the bacterium when the bacterium is termed “sensitive” to the at least one antibiotic, b) incubating the sample with the at least one antibiotic, c) purifying the sample by removing the intact bacteria and the cell debris, d) analyzing the purified sample by mass spectrometry, e) detecting the presence or absence of at least one peak of at least one protein characteristic of the bacterium, and f) determining the sensitivity or the resistance of the bacterial population to the antibiotic.Type: ApplicationFiled: November 13, 2020Publication date: December 22, 2022Applicant: BIOMERIEUX SAInventors: Jean-Philippe CHARRIER, Nadine PERROT, Gilles ZAMBARDI
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Publication number: 20210363563Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.Type: ApplicationFiled: August 3, 2021Publication date: November 25, 2021Applicant: BIOMERIEUXInventors: Sylvain ORENGA, Céline ROGER-DALBERT, John PERRY, Vanessa CHANTEPERDRIX, Gilles ZAMBARDI, Nathalie BAL
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Patent number: 11111518Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.Type: GrantFiled: November 8, 2019Date of Patent: September 7, 2021Assignee: BIOMERIEUXInventors: Sylvain Orenga, Céline Roger-Dalbert, John Perry, Vanessa Chanteperdrix, Gilles Zambardi, Nathalie Bal
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Publication number: 20200071742Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Applicant: BIOMERIEUXInventors: Sylvain ORENGA, Céline ROGER-DALBERT, John PERRY, Vanessa CHANTEPERDRIX, Gilles ZAMBARDI, Nathalie BAL
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Patent number: 10494658Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.Type: GrantFiled: November 7, 2016Date of Patent: December 3, 2019Assignee: BIOMERIEUX SAInventors: Sylvain Orenga, Céline Roger-Dalbert, John Perry, Vanessa Chanteperdrix, Gilles Zambardi, Nathalie Bal
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Patent number: 9995751Abstract: A method of detection, for at least one microorganism contained in a sample, of at least one marker of resistance to a glycopeptide, including the detection, by mass spectrometry, of at least one peptide or protein of the microorganism. Preferably, the glycopeptide is vancomycin. Preferably, the peptide is derived from a protein of type vanA, vanB, vanC, vanD, vanE, vanG, vanL, vanM or vanN.Type: GrantFiled: July 30, 2013Date of Patent: June 12, 2018Assignee: BIOMERIEUXInventors: Yannick Charretier, Jean-Philippe Charrier, Christine Franceschi, Gilles Zambardi
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Publication number: 20180155757Abstract: A method for discriminating carbapenem-resistant bacteria according to whether or not they develop resistance by membrane impermeability, the method including the following steps: providing a bacterial strain that is resistant to at least one carbapenem, evaluating the sensitivity of the bacterial strain with regard to at least one indicator carbapenem, on the one hand in the absence of polymyxin B nonapeptide (PMBN) and, on the other hand, in the presence of PMBN in a non-inhibitory concentration, establishing a prognosis of resistance by membrane impermeability in the case where the presence of PMBN makes it possible to significantly increase the sensitivity of the bacterial strain with regard to at least one indicator carbapenem used.Type: ApplicationFiled: May 19, 2016Publication date: June 7, 2018Applicants: BIOMÉRIEUX, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE D'AIX MARSEILLE, SERVICE DE SANTÉ DES ARMÉES (SSA)Inventors: Christine FRANCESCHI, Elisabeth PINET, Jean-Marie PAGES, Gilles ZAMBARDI
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Patent number: 9874570Abstract: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a cephalosporin, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.Type: GrantFiled: October 17, 2016Date of Patent: January 23, 2018Assignee: BIOMERIEUX, INC.Inventors: Yannick Charretier, Jean-Philippe Charrier, Christine Franceschi, Gilles Zambardi, Tiphaine Cecchini, Elodie Degout-Charmette
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Patent number: 9874568Abstract: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterized in that the antimicrobial is a carbapenem, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.Type: GrantFiled: December 6, 2016Date of Patent: January 23, 2018Assignee: BIOMERIEUX, INC.Inventors: Yannick Charretier, Jean-Philippe Charrier, Christine Franceschi, Gilles Zambardi, Tiphaine Cecchini, Elodie Degout-Charmette
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Publication number: 20170082636Abstract: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a carbapenem, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.Type: ApplicationFiled: December 6, 2016Publication date: March 23, 2017Applicant: BIOMERIEUX, INC.Inventors: Yannick CHARRETIER, Jean-Philippe CHARRIER, Christine FRANCESCHI, Gilles ZAMBARDI, Tiphaine CECCHINI, Elodie DEGOUT-CHARMETTE
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Publication number: 20170058317Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.Type: ApplicationFiled: November 7, 2016Publication date: March 2, 2017Applicant: BiomerieuxInventors: Sylvain Orenga, Céline Roger-Dalbert, John Perry, Vanessa Chanteperdrix, Gilles Zambardi, Nathalie Bal
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Publication number: 20170052198Abstract: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a cephalosporin, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.Type: ApplicationFiled: October 17, 2016Publication date: February 23, 2017Applicant: BIOMERIEUX, INC.Inventors: Yannick CHARRETIER, Jean-Philippe CHARRIER, Christine FRANCESCHI, Gilles ZAMBARDI, Tiphaine CECCHINI, Elodie DEGOUT-CHARMETTE
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Patent number: 9562899Abstract: A method of detecting and/or specifically identifying bacteria producing OXA-048-type carbapenemase in a biological sample, includes the steps of: (a) placing the biological sample likely to contain the bacteria in contact with a reaction medium including at least one chromogenic substrate to detect an enzymatic activity, and temocillin at a concentration equal to or greater than 150 mg/L, preferably between 200 and 500 mg/L, (b) incubating the sample in the medium to allow the bacteria to grow, and (c) detecting the strains corresponding to the OXA-48 carbapenemase producing bacteria. A culture medium as implemented in step (a) is also provided.Type: GrantFiled: July 29, 2013Date of Patent: February 7, 2017Assignee: bioMérieuxInventors: Laurence Devigne, Sandrine Ghirardi, Gilles Zambardi
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Patent number: 9551020Abstract: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a carbapenem, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.Type: GrantFiled: April 20, 2012Date of Patent: January 24, 2017Assignee: BIOMERIEUX, INC.Inventors: Yannick Charretier, Jean-Philippe Charrier, Christine Franceschi, Gilles Zambardi, Tiphaine Cecchini, Elodie Degout-Charmette
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Patent number: 9506932Abstract: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterized in that the antimicrobial is a cephalosporin, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.Type: GrantFiled: April 20, 2012Date of Patent: November 29, 2016Assignee: BIOMERIEUX, INC.Inventors: Yannick Charretier, Jean-Philippe Charrier, Christine Franceschi, Gilles Zambardi, Tiphaine Cecchini, Elodie Degout-Charmette
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Patent number: 9347888Abstract: Disclosed is a process for detecting and/or identifying, in a biological sample, bacteria exhibiting a resistance to carbapenems, including: a) contacting said sample with a reaction medium including at least one chromogenic agent and faropenem and/or doripenem; b) incubating the whole so as to allow the bacteria to grow; and c) detecting the strains exhibiting a resistance to carbapenems. The medium employed in step a) also contains cloxacillin and/or a combination of cloxacillin and PAbetaN.Type: GrantFiled: March 16, 2012Date of Patent: May 24, 2016Assignee: BIOMERIEUXInventors: Sandrine Ghirardi, John Perry, Gilles Zambardi
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Publication number: 20150247177Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.Type: ApplicationFiled: May 18, 2015Publication date: September 3, 2015Applicant: BIOMERIEUXInventors: Sylvain ORENGA, Céline ROGER-DALBERT, John PERRY, Vanessa CHANTEPERDRIX, Gilles ZAMBARDI, Nathalie BAL
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Publication number: 20150204883Abstract: The present invention relates to a method of detection, for at least one microorganism contained in a sample, of at least one marker of resistance to a glycopeptide, including the detection, by mass spectrometry, of at least one peptide or protein of said microorganism. Preferably, the glycopeptide is vancomycin. Preferably, said peptide is derived from a protein of type vanA, vanB, vanC, vanD, vanE, vanG, vanL, vanM or vanN.Type: ApplicationFiled: July 30, 2013Publication date: July 23, 2015Inventors: Yannick Charretier, Jean-Philippe Charrier, Christine Franceschi, Gilles Zambardi
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Publication number: 20150160211Abstract: A method of detecting and/or specifically identifying bacteria producing OXA-048-type carbapenemase in a biological sample, includes the steps of: (a) placing the biological sample likely to contain the bacteria in contact with a reaction medium including at least one chromogenic substrate to detect an enzymatic activity, and temocillin at a concentration equal to or greater than 150 mg/L, preferably between 200 and 500 mg/L, (b) incubating the sample in the medium to allow the bacteria to grow, and (c) detecting the strains corresponding to the OXA-48 carbapenemase producing bacteria. A culture medium as implemented in step (a) is also provided.Type: ApplicationFiled: July 29, 2013Publication date: June 11, 2015Applicant: BIOMERIEUXInventors: Laurence Devigne, Sandrine Ghirardi, Gilles Zambardi
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Publication number: 20150031063Abstract: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a carbapenem, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.Type: ApplicationFiled: April 20, 2012Publication date: January 29, 2015Applicant: BIOMERIEUX, INC.Inventors: Yannick Charretier, Jean-Philippe Charrier, Christine Franceschi, Gilles Zambardi, Tiphaine Cecchini, Elodie Degout-Charmette