Abstract: The present invention relates to an occluder device (1) comprising a supporting structure (2) said supporting structure (2) comprising a central portion (201) having a distal end (202) and a proximal end (203); said supporting structure (2) comprising distal branches (204) extending away from said distal end (202) of the central portion (201); said supporting structure (2) comprising proximal branches (205) extending away from said proximal end (203) of the central portion (201); said proximal and distal branches (204, 205) defining elastic hooked struts which are rotatable away from the central portion (201) to anchor a septum (7) of a heart (103); said occluder device (1) further comprising at least one membrane (8); said membrane (8) comprises a membrane body (11) connected to the distal or proximal branches (204; 205); when the branches (204, 205) are in the unfolded or lying position, said membrane (8) has a closed position where the membrane (8) is in a configuration which provides maximum occlusion to

Abstract: A crossable interseptal occluder device has a support structure having a central support structure portion delimiting a lumen, anchoring portions, and is configured to contract and expand between a compressed configuration and an expanded configuration in which the anchoring portions extend radially outwards from the central support structure portion to compress a partition by arranging the support structure astride the partition through a defect or hole. A diaphragm configured to close the majority of the lumen when the diaphragm is in a relaxed configuration, allows a medical device inserted into a first compartment delimited by the partition to pass through the diaphragm and the lumen entering a second compartment. The diaphragm has a plurality of occluding bridges, each having an elongated body with body ends and longitudinal edges. In the relaxed configuration of the diaphragm, each occluding bridge is arranged close to a further occluding bridge.

Abstract: A valvular sleeve for valvular prostheses including a tubular body extending between an inflow end and an outflow end, the tubular body including a sheet member folded at the outflow end, whereby the tubular body includes an inner tubular portion and an outer tubular portion surrounding the inner tubular portion.

Abstract: A tissue retractor has a retractor body delimiting a central device opening and proximal and distal body ends. The proximal body end has a proximal flange having inner and outer proximal flange edges and a proximal flange body extending, with the retractor not delivered, away from the central device opening. The distal body end has a distal flange having inner and outer distal flange edges and a distal flange body extending, with the retractor not delivered, away from the central device opening. The retractor body has a retractor neck having a proximal end connected to the inner proximal flange edge and a distal end connected to the inner distal flange edge. The proximal flange has a proximal flange portion having concavity facing the distal flange, which has a distal concave flange portion having concavity, where the concavities are facing the same direction, and is dome segment-shaped or spherical crown-shaped.

Abstract: A holder for a heart valve prosthesis, the holder including a hub portion having a longitudinal axis, an engagement portion coupled to the hub portion and including plural finger members variably positionable relative to the hub portion between a collapsed condition wherein the finger members are closed onto the hub portion and an expanded condition wherein the finger members radially protrude with respect to the hub portion to engage a heart valve prosthesis.

Abstract: A valvular sleeve for valvular prostheses including a tubular body extending between an inflow end and an outflow end, the tubular body including a sheet member folded at the outflow end, whereby the tubular body includes an inner tubular portion and an outer tubular portion surrounding the inner tubular portion.

Abstract: A device for measuring an internal dimension of a native cardiac valve annulus includes an elongated support member having a proximal portion and a distal portion. A measuring portion is coupled to the distal portion, and an indicator is coupled to the proximal portion of the support member. The measuring portion is biased towards a deployed configuration such that when deployed it applies an outwardly directed radial force to the native valve annulus.

Abstract: A collapsible valve prosthesis includes an armature and a set of prosthetic valve leaflets supported by the armature. The armature is expandable from a contracted condition to an expanded condition for anchoring at an annulus of a natural valve site, and includes a tubular intra-annular portion defining a blood flow lumen having an inflow side and an outflow side. The tubular intra-annular portion supports the prosthetic valve leaflets in the blood flow lumen and is provided with outward formations for coupling with the natural valve site. The armature includes an over-annular portion linked to the intra-annular portion to extend collar-like over the annulus of the natural valve site at the inflow side of the blood flow lumen. The armature may also include an under-annular portion to extend collar-like at the outflow side of the blood flow lumen. The prosthesis may permit mitral valve replacement (MVR) without removing the native valve leaflets and the chordae tendineae.

Abstract: A holder for a heart valve prosthesis, the holder including a hub portion having a longitudinal axis, an engagement portion coupled to the hub portion and including plural finger members variably positionable relative to the hub portion between a collapsed condition wherein the finger members are closed onto the hub portion and an expanded condition wherein the finger members radially protrude with respect to the hub portion to engage a heart valve prosthesis.

Abstract: A holder for heart valve prostheses, the holder including a hub portion having a longitudinal axis, an engagement portion coupled to the hub portion and including plural L-shaped finger members variably positionable relative to the hub portion between a collapsed condition wherein the finger members are closed onto the hub portion and an expanded condition wherein the finger members radially protrude with respect to the hub portion to engage a heart valve prosthesis.

Abstract: A device for measuring an internal dimension of a native cardiac valve annulus includes an elongated support member having a proximal portion and a distal portion. A measuring portion is coupled to the distal portion, and an indicator is coupled to the proximal portion of the support member. The measuring portion is biased towards a deployed configuration such that when deployed it applies an outwardly directed radial force to the native valve annulus.

Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.

Abstract: A support device for implanting a stentless heart valve prosthesis having three leaflets adapted for coapting and defining three corresponding commissures is disclosed. The support device includes a shaft defining a manipulation axis, the shaft having a proximal portion and a distal portion, and three support formations integrally formed and extending from the proximal end of the shaft, the support formations angularly distributed about the manipulation axis of the shaft, such that each of the support formations correspond to locations of each of the commissures of the stentless heart valve prosthesis. The shaft includes a connection portion flexibly connecting the shaft and the support formations to permit a displacement of the manipulation axis with respect to the support formations. The shaft, the plurality of support formations and the connection portion are integrally formed from a single tubular element.

Abstract: Disclosed herein are various embodiments of a holder (1) for heart valve prostheses (V). Embodiments of the holder (1) include: a hub portion (2) having a longitudinal axis (X1), an engagement portion (4) coupled to the hub portion (2) and including plural finger members (5) variably positionable relative to the hub portion (2) between a collapsed condition wherein the finger members (5) are closed onto the hub portion (2) and an expanded condition wherein the finger members (5) radially protrude with respect to the hub portion (2) to engage a heart valve prosthesis (V). The finger members (5) are L-shaped. Also disclosed are a storage arrangement and delivery instrument and a kit for crimping, loading and delivering an expandable heart valve prosthesis (V).

Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.

Abstract: A device for anchoring a prosthetic heart valve on biological tissue, includes first and second anchoring assemblies, mutually couplable to secure biological tissue therebetween. The anchoring assemblies include at least one pair of complementary arched portions having anchoring formations for anchoring on the biological tissue. The anchoring formations include integral extensions of the anchoring assemblies extending radially outwardly of one of the anchoring assemblies.

Abstract: A support device for implanting stentless valve prostheses, such as biological heart valves, includes a hub and a plurality of support portions for supporting the stentless valve prosthesis. The hub defines a manipulation axis for the device and is flexibly connected to the support portions to allow displacing the manipulation axis for the device between the support portions.

Abstract: Described is a valve prosthesis comprising: an annular structure, and a plurality of valve leaflets, and a plurality of anchoring members attached around the annular structure, the anchoring members including: a web portion coupled to the annular structure and extending axially thereto, and two end portions at axially opposed sides of the web portion, the end portions having: an insertion condition for insertion of the prosthesis, wherein the end portions are aligned to the web portion and extend axially with respect to the annular structure; and an anchoring condition for anchoring the prosthesis, wherein the end portions extend at an angle to the web portion radially outwardly of the annular structure to provide anchoring of the prosthesis proximally and distally, respectively, of the annulus, and wherein one end portion forms an obtuse angle with the web portion.

Abstract: A device for anchoring on biological tissue a prosthetic heart valve, includes first and second anchoring assemblies mutually couplable to secure biological tissue therebetween. The anchoring assemblies include at least one pair of complementary arched portions having anchoring formations for anchoring on the biological tissue. The anchoring formations include integral extensions of the anchoring assemblies extending radially outwardly of one of the anchoring assemblies.

Abstract: A kit for implanting a prosthetic vascular conduit includes a prosthetic vascular conduit for coupling to a prosthetic valve having an annular portion. The conduit includes a terminal collar member for receiving the valve. The kit further includes a holder including a shaft and a hub including a receiving portion configured for housing a prosthetic valve. The conduit is fitted on the holder so that at least a portion of the conduit wraps over the receiving portion of the hub. A sleeve member fitted onto the conduit in a position corresponding to the receiving portion of the hub, and a portion of the collar member is wrapped or folded over the sleeve member. The sleeve member is slidable away from the hub to unwrap the collar member such that it is disposed around the annular portion of a prosthetic valve.