Patents by Inventor Glenn Friedrich

Glenn Friedrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vectors for making genomic modifications
    Patent number: 7332338
    Abstract: Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: February 19, 2008
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Brian Zambrowicz, Glenn A. Friedrich, Arthur T. Sands
  • Novel human proteases and polynucleotides encoding the same
    Publication number: 20080003673
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: September 6, 2005
    Publication date: January 3, 2008
    Inventors: Alejandro Abuin, Gregory Donoho, Carl Friddle, Glenn Friedrich, Brenda Gerhardt, Erin Hilbun, Yi Hu, James Kieke, Maricar Miranda, Michael Nehls, Boris Nepomnichy, Andrew Olson, Arthur Sands, John Scoville, C. Turner, D. Walke, Nathaniel Wilganowski, Xuanchuan Yu, Brian Zambrowicz
  • Novel human membrane proteins and polynucleotides encoding the same
    Publication number: 20070298489
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: October 5, 2005
    Publication date: December 27, 2007
    Inventors: Alejandro Abuin, Michael Burnett, Gregory Donoho, Carl Friddle, Glenn Friedrich, Brenda Gerhardt, Erin Hilbun, Yi Hu, Brian Mathur, Michael Nehls, Boris Nepomnichy, Arthur Sands, John Scoville, C. Turner, D. Walke, Xiaoming Wang, Frank Wattler, Nathaniel Wilganowski, Brian Zambrowicz
  • Polynucleotides encoding human transporter proteins
    Patent number: 7268222
    Abstract: Novel human ATP binding cassette transporter polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: September 11, 2007
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Marie Harras, Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Novel lipoxygenase proteins and polynucleotides encoding the same
    Publication number: 20070136832
    Abstract: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
    Type: Application
    Filed: November 16, 2006
    Publication date: June 14, 2007
    Inventors: C. Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur Sands
  • Lipoxygenase proteins and polynucleotides encoding the same
    Patent number: 7144730
    Abstract: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: December 5, 2006
    Assignee: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Jr., Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur T. Sands
  • Novel human genes and proteins encoded thereby
    Publication number: 20060090212
    Abstract: The present invention relates to novel human genes involved in the regulation of signal transduction pathways, and the proteins and polypeptides encoded thereby. In particular, the invention relates to polynucleotides that encode the polypeptides, the polypeptides, antibodies directed to the polypeptides, and methods of diagnosis and treatment of various disorders, including disorders involving the inappropriate regulation of a signal transduction mechanism, for example cancer.
    Type: Application
    Filed: December 18, 2002
    Publication date: April 27, 2006
    Inventors: Alexander Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur Sands
  • Novel human enzymes and polynucleotides encoding the same
    Publication number: 20060063245
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: September 15, 2005
    Publication date: March 23, 2006
    Inventors: D. Walke, Nathaniel Wilganowski, C. Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur Sands
  • Novel human GABA receptor proteins and polynucleotides encoding the same
    Publication number: 20060025581
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: July 25, 2005
    Publication date: February 2, 2006
    Inventors: C. Turner, Brian Mathur, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human transferase proteins and polynucleotides encoding the same
    Publication number: 20050287568
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 29, 2005
    Inventors: Gregory Donobo, Erin Hilbun, C. Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur Sands, D. Walke, Nathaniel Wilganowski, Yi Hu, James Kieke, David Potter
  • Novel human membrane protein and polynucleotides encoding the same
    Publication number: 20050261488
    Abstract: The nucleotide and amino acid sequences of a novel human G protein-coupled receptor (NGPCR) is disclosed. The NGPCR is somewhat similar to human latrophilin, lectomedin, and serpentine, proteins, among others.
    Type: Application
    Filed: March 31, 2005
    Publication date: November 24, 2005
    Inventors: D. Walke, Nathaniel Wilganowski, C. Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur Sands
  • Noved human proteases and polynucleotides encoding the same
    Publication number: 20050222401
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: January 10, 2005
    Publication date: October 6, 2005
    Inventors: Gregory Donoho, John Scoville, C. Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur Sands
  • Novel human proteases and polynucleotides encoding the same
    Publication number: 20050214783
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: July 12, 2004
    Publication date: September 29, 2005
    Inventors: D. Walke, C. Turner, Alejandro Abuin, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human phosphatases and polynucleotides encoding the same
    Publication number: 20050208571
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: May 12, 2005
    Publication date: September 22, 2005
    Inventors: D. Walke, John Scoville, C. Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur Sands
  • NOVEL HUMAN CARBOXYPEPTIDASES AND POLYNUCLEOTIDES ENCODING THE SAME
    Publication number: 20050191641
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: June 21, 2004
    Publication date: September 1, 2005
    Inventors: Gregory Donoho, C. Turner, Michael Nebls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel mutated mammalian cells and animals
    Publication number: 20050186677
    Abstract: Novel mutated mammalian cells are provided that have been characterized by identifying the sequence of the genes that have been mutated. Preferably, novel mutated cells are murine ES cells that stably incorporate retroviral gene trap constructs in the specifically identified genes. The novel mutated cells and animals are useful in functional genomic analysis, and in the discovery and development of new therapeutic and diagnostics agents and methods.
    Type: Application
    Filed: October 13, 2004
    Publication date: August 25, 2005
    Inventors: Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human ATPase proteins and polynucleotides encoding the same
    Publication number: 20050182248
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: January 3, 2005
    Publication date: August 18, 2005
    Inventors: Gregory Donoho, C. Turner, Erin Hilbun, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Human transferase proteins and polynucleotides encoding the same
    Patent number: 6929937
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: February 11, 2003
    Date of Patent: August 16, 2005
    Assignee: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Jr., Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands, D. Wade Walke, Nathaniel L. Wilganowski
  • Novel human proteases and polynucleotides encoding the same
    Publication number: 20050170395
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: December 30, 2004
    Publication date: August 4, 2005
    Inventors: Gregory Donoho, C. Turner, Glenn Friedrich, John Scoville, Brian Zambrowicz, Arthur Sands
  • Novel human kinase protein and polynucleotides encoding the same
    Publication number: 20050170364
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: April 21, 2004
    Publication date: August 4, 2005
    Inventors: Gregory Donoho, Erin Hilbun, C. Turner, Glenn Friedrich, Brian Zambrowicz, Arthur Sands