Patents by Inventor Glenn Friedrich

Glenn Friedrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indexed library of cells containing genomic modifications and methods of making and utilizing the same
    Patent number: 6855545
    Abstract: Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the gene of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: February 15, 2005
    Assignee: Lexicon Genetics Inc.
    Inventors: Arthur T. Sands, Glenn A. Friedrich, Brian Zambrowicz, Allan Bradley
  • Human proteases and polynucleotides encoding the same
    Patent number: 6852521
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: February 8, 2005
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Glenn Friedrich, John Scoville, Brian Zambrowicz, Arthur T. Sands
  • Novel human enzymes and polynucleotides encoding the same
    Publication number: 20050009087
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: August 16, 2004
    Publication date: January 13, 2005
    Inventors: Gregory Donoho, Erin Hilbun, John Scoville, C. Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur Sands
  • Human endothelin converting enzyme-like proteins and polynucleotides encoding the same
    Patent number: 6835564
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: December 28, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Vectors for gene mutagenesis and gene discovery
    Publication number: 20040259253
    Abstract: Novel vectors are described that incorporate, inter alia, a novel 3′ gene trap cassette that does not encode a marker conferring antibiotic resistance and which can be used to efficiently trap, mutagenize, and identify previously unknown cellular genes. Vectors incorporating the presently described 3′ gene trap cassette find particular application in gene discovery, and the production of mutated cells and animals.
    Type: Application
    Filed: March 9, 2004
    Publication date: December 23, 2004
    Applicant: Lexicon Genetics Inc.
    Inventors: Brian Zambrowicz, Glenn A. Friedrich, Stan Lilleberg, Arthur T. Sands
  • Novel human transferase proteins and polynucleotides encoding the same
    Publication number: 20040214202
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: December 9, 2003
    Publication date: October 28, 2004
    Inventors: D. Wade Walke, C. Alexander Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands
  • Vectors for gene mutagenesis and gene discovery
    Patent number: 6808921
    Abstract: Novel vectors are described that incorporate, inter alia, a novel 3′ gene trap cassette that does not encode a marker conferring antibiotic resistance and which can be used to efficiently trap, mutagenize, and identify previously unknown cellular genes. Vectors incorporating the presently described 3′ gene trap cassette find particular application in gene discovery, and the production of mutated cells and animals.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: October 26, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Brian Zambrowicz, Glenn A. Friedrich, Stan Lilleberg, Arthur T. Sands
  • Human kinase proteins and polynucleotides encoding the same
    Patent number: 6806073
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: October 19, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Jr., Glenn Friedrich, Brian Zambrowicz, Alejandro Abuin, Arthur T. Sands
  • Human LDL receptor encoding polynucleotides
    Patent number: 6806083
    Abstract: The present invention relates to LDLPs, nucleotides encoding the same, and methods and compositions for the treatment of biological disorders regulatable by the controlled expression, binding, and/or inhibition of the described LDLPs.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: October 19, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Jr., Brian Zambrowicz, Glenn Friedrich, Arthur T. Sands
  • Novel human proteases and polynucleotides encoding the same
    Publication number: 20040203059
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: May 11, 2004
    Publication date: October 14, 2004
    Inventors: Gregory Donoho, Erin Hilbun, C. Alexander Turner, Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Novel human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
    Publication number: 20040198968
    Abstract: Novel human polunucleotide and polypeptide sequences are disclosed that can be used in therapeuutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: January 20, 2004
    Publication date: October 7, 2004
    Inventors: Gregory Donoho, C. Alexander Turner, Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Human carboxypeptidases and polynucleotides encoding the same
    Patent number: 6780640
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: August 24, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Human proteases and polynucleotides encoding the same
    Patent number: 6777221
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: August 17, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, Erin Hilbun, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Vectors for gene mutagenesis and gene discovery
    Patent number: 6776988
    Abstract: Novel vectors are described that incorporate, inter alia, a novel 3′ gene trap cassette which can be used to efficiently trap and identify previously unknown cellular genes. Vectors incorporating the described 3′ gene trap cassette find particular application in gene discovery and in the production of mutated cells and animals.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: August 17, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Brian Zambrowicz, Glenn A. Friedrich, Stan Lilleberg, Arthur T. Sands
  • Novel human ion channel protein and polynucleotides encoding the same
    Publication number: 20040157259
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: March 18, 2004
    Publication date: August 12, 2004
    Inventors: Yi Hu, James Alvin Kieke, C. Alexander Turner, Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Human ion channel protein and polynucleotides encoding the same
    Patent number: 6767736
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: July 27, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Yi Hu, James Alvin Kieke, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Novel human thrombospondin repeat proteins and polynucleotides encoding the same
    Publication number: 20040143113
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: January 20, 2004
    Publication date: July 22, 2004
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Novel human proteases and polynucleotides encoding the same
    Publication number: 20040137502
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: January 28, 2004
    Publication date: July 15, 2004
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands
  • Human kinase protein and polynucleotides encoding the same
    Patent number: 6746861
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: June 8, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, Erin Hilbun, C. Alexander Turner, Jr., Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Human proteases and polynucleotides encoding the same
    Patent number: 6743621
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: June 1, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Jr., Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands