Abstract: An intraocular drug delivery platform including a ring having an anterior surface and a posterior surface opposite the anterior surface, a central aperture formed by the ring, a first haptic coupled to and extending outwards from the ring, a second haptic coupled to and extending outwards from the ring, a first drug eluting mass operably coupled to the anterior surface of the ring, and a second drug eluting mass operably coupled to the anterior surface of the ring and positioned directly opposite of the first drug eluting mass.

Abstract: An intraocular drug delivery platform for use with an intraocular lens assembly. The platform includes a ring and haptics to maintain the ring in position in the capsular bag, compartments on the anterior surface of the ring for accommodating a drug eluting matrix or other drug mass, and a skirt extending posteriorly from the posterior surface of the ring to constrain movement, including lateral or inferior/superior movement, of the intraocular lens relative to the ring.

Abstract: A system and method include a controller configured to obtain or receive a predicted weather event along a route during a current or upcoming trip based on weather data. The controller determines a weather fitness of a first vehicle for traveling on the route during the trip based on the predicted weather event and equipment characteristics of equipment disposed onboard the first vehicle. The controller assigns one of the first vehicle or a different, second vehicle to complete the trip based at least in part on the weather fitness of the first vehicle.

Abstract: Disclosed are novel crystalline forms of gepotidacin and pharmaceutical compositions containing the same. Also disclosed are processes for the preparation thereof and methods for use thereof.

Abstract: A high temperature secondary seal between a rotating seal face adaptor sleeve and a rotating shaft does not consume additional axial space beyond the axial space occupied by the secondary seal. The seal includes a single ring drive collar comprising a plurality of radial directed bolts in tapped holes. As the bolts are tightened they enter a cylindrical cavity in the drive collar and impact therein a sloped surface of a crush ring. The vertical force thereby applied to the crush ring displaces the crush ring axially into a secondary graphite sealing element, thereby crushing the secondary sealing element against the adaptor sleeve and shaft, and forming a seal there between. The crush ring sloped surface can terminate in a vertical face, so that upon sufficient displacement of the crush ring the bolts abut the vertical face and impact the shaft, fixing the drive collar to the shaft.

Abstract: A vehicle control system and method include processors that determine that an energy storage device of a vehicle will have insufficient energy to power a propulsion system of the vehicle under a first set of operational settings to move the vehicle from a first location within a powered segment to a designated second location that is outside of an unpowered segment of a route. Responsive to determining that the energy storage device will have insufficient energy, the processors change one or more settings of the vehicle to operate the vehicle under a second set of operational settings while the vehicle moves within the powered segment of the route to charge the energy storage device to a greater extent relative to operating of the vehicle according to the first set of operational settings.

Abstract: Solar tracking installation includes first movement assembly which functionally engages with the primary axis shaft to cause rotation of the primary axis shaft around the primary axis for moving the plurality of planar modules of solar collector elements in a first rotational direction around the primary axis. The installation further includes a second movement assembly which functionally engages with the secondary movement member to cause tilting of each of the plurality of planar modules of solar collector elements around each respective pivotal mount. In this way the movement of the multitude of solar collection elements is a combination of the rotation of first movement assembly and the tilting motion caused by the second movement assembly.

Abstract: An inspection system includes sensors that are selectively coupled to a vehicle during an inspection and/or maintenance event for the vehicle and a controller that is operable to cause a control system of the vehicle to initiate a first operation and a different, second operation. The controller determines whether first sensor information indicative of a state of the vehicle during the first operation exists. The controller sends a command signal to the control system to direct the control system to change vehicle operations from the first operation to the second operation responsive to determining that the first sensor information is lacking. The controller obtains second sensor information from the sensors based on the second operation and determines a condition of the vehicle based on the first and/or second sensor information.

Abstract: A vehicle control system and method include one or more processors that determine that a vehicle has or will have insufficient energy to power a propulsion system of the vehicle under a first set of operational settings to move the vehicle from a first location to a designated second location that is outside of an unpowered segment of a route along which the vehicle moves. Responsive to determining that the vehicle has or will have insufficient energy, the one or more processors change one or more of a throttle setting or a brake setting of the vehicle to operate the vehicle under a second set of operational settings while the vehicle moves within a powered segment of the route.

Abstract: A vehicle sensor unit includes a communication device configured to communicate with one or more other sensor units, a controller of a vehicle system on which the vehicle sensor unit is disposed, and one or more sensors; a sensor configured to sense one or more characteristics of a vehicle on which the vehicle sensor unit is disposed; and a controller configured to determine one or more operating conditions of the vehicle based on the one or more characteristics that are sensed by the sensor. The controller is configured to control the communication device to communicate the one or more characteristics, the one or more operating conditions, or both the one or more characteristics and the one or more operating conditions. The communication device and the sensor are configured to be disposed onboard the vehicle that does not have an internal source of electric power.

Abstract: A system and method includes determining, with a sensor assembly disposed onboard a first aerial vehicle, a direction in which a fluid flows within or through the first aerial vehicle, and determining an orientation of the first aerial vehicle relative to a second aerial vehicle based at least in part on the direction in which the fluid flows within or through the first aerial vehicle.

Abstract: A blow moulding machine for blow moulding a container having an integrally formed handle; said container blow moulded from a previously injection moulded preform; said preform comprising a body portion and said integrally formed handle; said machine including a preform loading station at which said preform is oriented by a preform orienting apparatus.

Abstract: Some aspects of what is described here relate to seismic profiling techniques. A seismic excitation is generated in a first directional section of a first wellbore in a subterranean region. Seismic responses associated with the seismic excitation are detected in directional sections of a plurality of other wellbores in the subterranean region. A fracture treatment of the subterranean region is analyzed based on the seismic responses. In some instances, a multi-dimensional seismic velocity model of the subterranean region is generated based on the seismic responses.

Abstract: A pressure retained gasket seal provides enhanced resistance to hydraulic unloading by including a notch formed in a rear face of the gasket groove, thereby reducing intrusion of process fluid behind the gasket and improving hydraulic retention of the gasket seal. Embodiments increase the process fluid pressure limit of the gasket seal by a factor of two or three compared to gasket seals of the prior art. In embodiments, the gasket groove has a dovetail cross-section, thereby increasing resistance to process fluid pressure by requiring compression of the gasket before it can be dislodged from the groove. Embodiments form the gasket from flexible graphite, which can be initially shaped as an annulus and then forced by an applied load into the gasket groove in conformance with the notch. Embodiments include compressing the graphite to within 50% or even 70% of its maximum density during installation thereof.

Abstract: System includes a controller configured to obtain one or more of a route parameter or a vehicle parameter from discrete examinations of one or more of a route or a vehicle system. The route parameter is indicative of a health of the route over which the vehicle system travels. The vehicle parameter is indicative of a health of the vehicle system. The discrete examinations of the one or more of the route or the vehicle system separated from each other by one or more of location or time. The controller is configured to examine the one or more of the route parameter or the vehicle parameter to determine whether the one or more of the route or the vehicle system is damaged. The system also includes examination equipment configured to continually monitor the one or more of the route or the vehicle system responsive to determining that the one or more of the route or the vehicle is damaged.

Abstract: A high temperature secondary seal between a rotating seal face adaptor sleeve and a rotating shaft does not consume additional axial space beyond the axial space occupied by the secondary seal. The seal includes a single ring drive collar comprising a plurality of radial directed bolts in tapped holes. As the bolts are tightened they enter a cylindrical cavity in the drive collar and impact therein a sloped surface of a crush ring. The vertical force thereby applied to the crush ring displaces the crush ring axially into a secondary graphite sealing element, thereby crushing the secondary sealing element against the adaptor sleeve and shaft, and forming a seal there between. The crush ring sloped surface can terminate in a vertical face, so that upon sufficient displacement of the crush ring the bolts abut the vertical face and impact the shaft, fixing the drive collar to the shaft.

Abstract: System includes a controller configured to obtain one or more of a route parameter or a vehicle parameter from discrete examinations of one or more of a route or a vehicle system. The route parameter is indicative of a health of the route over which the vehicle system travels. The vehicle parameter is indicative of a health of the vehicle system. The discrete examinations of the one or more of the route or the vehicle system separated from each other by one or more of location or time. The controller is configured to examine the one or more of the route parameter or the vehicle parameter to determine whether the one or more of the route or the vehicle system is damaged. The system also includes examination equipment configured to continually monitor the one or more of the route or the vehicle system responsive to determining that the one or more of the route or the vehicle is damaged.

Abstract: A blow moulding machine for blow moulding a container having an integrally formed handle; said container blow moulded from a previously injection moulded preform; said preform comprising a body portion and said integrally formed handle; said machine including a preform loading station at which said preform is oriented by a preform orienting apparatus.

Abstract: A vehicle control system controls operation of motors of a vehicle and determines whether there is sufficient stored electric energy to power the vehicle through an unpowered segment of a route. The controller changes operation of the vehicle to ensure that the vehicle can travel completely through the unpowered segment by switching which energy storage device provides energy, changing vehicle speed, changing motor torque, changing which route is traveled on, selecting fewer motors to power the vehicle, requesting rendezvous with a recharging vehicle, running the energy storage devices in a degraded mode, initiating a motor to generate power to aid in propulsion and/or recharge the energy storage devices, selecting a different route, controlling the vehicle to draft or mechanically couple to another vehicle, and/or controlling the vehicle to gain momentum or to generate an overcharge.

Abstract: An intraocular drug delivery platform for use with an intraocular lens assembly. The platform includes a ring and haptics to maintain the ring in position in the capsular bag, compartments on the anterior surface of the ring for accommodating a drug eluting matrix or other drug mass, and a skirt extending posteriorly from the posterior surface of the ring to constrain movement, including lateral or inferior/superior movement, of the intraocular lens relative to the ring.