Abstract: Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

Abstract: Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

Abstract: The present invention provides a method of testing a dog to determine the likelihood that the dog is protected from liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO:142) and (b) one or more polymorphisms in linkage disequilibrium with (a).

Abstract: The present invention provides a method of testing a dog to determine the likelihood that the dog is protected from liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO:142) and (b) one or more polymorphisms in linkage disequilibrium with (a).

Abstract: The present invention provides a method of testing a dog to determine the likelihood that the dog is protected from liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO:142) and (b) one or more polymorphisms in linkage disequilibrium with (a).

Abstract: Pharmaceutical compositions and methods for the treatment of subjects, including humans, who have or are at risk for various disease, disorders and conditions, including, mitochondria-associated diseases, disorders, and conditions, including respiratory chain disorders, and diseases, disorders and conditions associated with or characterized at least in part by mitochondria swelling, mitochondria dysfunction, mitochondria leaking, oxidative stress, increased mitochondria number, increased mitochondria and mitochondria-related protein mass, and increased mitochondria and related-related proteins expression.

Abstract: The present invention provides a method of testing a dog to determine the susceptibility of the dog to liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from: (a) Chr22_3167534 (SEQ ID NO: 144), Chr22_3135144 (SEQ ID NO: 145), Chr20_55461150 (SEQ ID NO: 146), ChrX_120879711 (SEQ ID NO: 147), Chr19_6078084 (SEQ ID NO: 148), Chr15_62625262 (SEQ ID NO: 149), Chr14_39437543 (SEQ ID NO: 150), Chr15_62625024 (SEQ ID NO: 151), Chr3_86838677 (SEQ ID NO: 152), Chr24_4011833 (SEQ ID NO: 153), Chr18_60812198 (SEQ ID NO: 154), Chr10_65209946 (SEQ ID NO: 155), and the CGCCCC repeat at chromosome location 22:3135287; (b) one or more polymorphisms in linkage disequilibrium with a said polymorphism (a); and/or (c) Chr32_38904515 (SEQ ID NO: 156), Chr8_4892743 (SEQ ID NO: 157) and Chr8_4880518 (SEQ ID NO: 158).

Abstract: The present invention provides a method of testing a dog to determine the likelihood that the dog is protected from liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO:142) and (b) one or more polymorphisms in linkage disequilibrium with (a).

Abstract: A system and method for secure transport of data, the method comprising: sharing of key information with a key distributor, wherein the key information is for enabling decryption of first and second encrypted data, the key distributor being for making one or more decryption keys available to an authorized user; creating a container object, the container object comprising: first encrypted data having a first encryption based on at least a part of said key information; second encrypted data having a second encryption based on at least a part of said key information, wherein the first encryption is different to the second encryption; and metadata relating to the first encrypted data and the second encrypted data; and sending the container object to a data store or otherwise making the container object available, to allow user access to said data container object.

Abstract: A gas recovery system for a beverage dispensing system is provided. The system includes a mechanism for drawing gas from an at least partially used beverage container, a compressor downstream of the at least partially used beverage container, a gas separator downstream of the compressor, and a gas storage vessel downstream of the gas separator. The gas recovery system is configured to draw gas from the at least partially used beverage container, to separate the gas into component gases by passing the gas through the gas separator, and to selectively direct at least one of the separated component gases to the gas storage vessel.

Abstract: Pharmaceutical compositions and methods for the treatment of subjects, including humans, who have or are at risk for various disease, disorders and conditions, including, mitochondria-associated diseases, disorders, and conditions, including respiratory chain disorders, and diseases, disorders and conditions associated with or characterized at least in part by mitochondria swelling, mitochondria dysfunction, mitochondria leaking, oxidative stress, increased mitochondria number, increased mitochondria and mitochondria-related protein mass, and increased mitochondria and related-related proteins expression.

Abstract: The present invention provides a method of determining the susceptibility of a dog to liver copper accumulation, comprising detecting the presence or absence in the genome of the dog of (a) a polymorphism in the GOLGA5, ATP7a or UBL5 gene that is indicative of susceptibility to liver copper accumulation and/or (b) a polymorphism in linkage disequilibrium with a said polymorphism (a). The invention also provides a method of determining the likelihood that a dog is protected from liver copper accumulation comprising detecting the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO: 142) and (b) one or more polymorphisms in linkage disequilibrium with (a).

Abstract: The present invention provides a method of testing a dog to determine the likelihood that the dog is protected from liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO:142) and (b) one or more polymorphisms in linkage disequilibrium with (a).

Abstract: A gas recovery system for a beverage dispensing system, the gas recovery system comprising: means for drawing gas from an at least partially used beverage container, a compressor downstream of said at least partially used beverage container; a gas separator downstream of said compressor, a gas storage vessel downstream of said gas separator; wherein in use the gas recovery system is configured to draw gas from the at least partially used beverage container and to separate said gas into component gases by passing said gas through said gas separator, and to selectively direct at least one of the separated component gases to said gas storage vessel.

Abstract: A system and method for secure transport of data, the method comprising: sharing of key information with a key distributor, wherein the key information is for enabling decryption of first and second encrypted data, the key distributor being for making one or more decryption keys available to an authorised user; creating a container object, the container object comprising: first encrypted data having a first encryption based on at least a part of said key information; second encrypted data having a second encryption based on at least a part of said key information, wherein the first encryption is different to the second encryption; and metadata relating to the first encrypted data and the second encrypted data; and sending the container object to a data store or otherwise making the container object available, to allow user access to said data container object.

Abstract: The invention provides a method of predicting the size of a dog that will be attained in adulthood, comprising typing the nucleotide(s) present for a single nucleotide polymorphic (SNP) marker present in the genome of the dog at a position equivalent to position 201 in one or more of the sequences identified in Table 1, and/or at one or more positions which are in linkage disequilibrium with any one of these positions, and thereby predicting the size of the dog that will be attained in adulthood.

Abstract: The present invention provides a method of determining the susceptibility of a dog to liver copper accumulation comprising detecting the presence or absence of (a) a polymorphism in the GOLGA5, ATP7a or UBL5 gene of the dog that is indicative of susceptibility to copper accumulation and/or (b) a polymorphism in linkage disequilibrium with a said polymorphism (a), and thereby determining the susceptibility of the dog to liver copper accumulation. The invention also provides a foodstuff comprising copper at a concentration of less than 21 mg/kg dry matter for use in preventing a disease attributable to liver copper accumulation in a dog having genetic inheritance of the Labrador Retriever breed.

Abstract: A method of determining susceptibility to periodontitis in a Shih Tzu dog, Yorkshire Terrier dog or a dog of a breed that is genetically related to the Shih Tzu or Yorkshire Terrier breed, comprises: a) typing the nucleotide present in the genome of the dog at or at a position equivalent to each of the following: position 201 of SEQ ID NO: 2 (SNP_02), or a position that is in linkage disequilibrium with this position,—position 201 of SEQ ID NO: 4 (SNP_04), or a position that is in linkage disequilibrium with this position, and position 201 of SEQ ID NO: 9 (SNPJ39), or a position that is in linkage disequilibrium with this position, and b) thereby determining whether the dog is susceptible to periodontitis.

Abstract: A gas reclamation system for use in a beverage dispensing system. The system includes a valve for releasable connection to a used beverage container containing a pressurized gas, the valve allowing release of gas from the container. A filter for removal of particulate matter from the gas and a sterilizer for removal of bacteria from the gas are also provided, together with a compressor to re-pressurize the filtered and sterilized gas for supply to the beverage dispensing system. The system may be used for carbon dioxide recovery from beverage containers, reducing the consumption of carbon dioxide from beverage dispensing systems.