Abstract: A method for determining an object's size based on calibration data is disclosed. The calibration data is measured by capturing images with an image sensor and a lens module, having at least one objective, of the capsule camera at a plurality of object distances and/or back focal distances and deriving from the images characterizing a focus of each objective for at least one color plane. Images of lumen walls of gastrointestinal (GI) tract are captured using the capsule camera. Object distance for at least one region in the current image is estimated based on the camera calibration data and relative sharpness of the current image in at least two color planes. The size of the object is estimated based on the object distance estimated for one or more regions overlapping with an object image of the object and the size of the object image.

Abstract: A method and system for displaying images captured by an in vivo imaging device are disclosed. Embodiments according to the present invention display image sequence data in a first display area. When a first annotated image is displayed in the first display area, a first thumbnail image in a second display area corresponding to the first annotated image is replaced to indicate an occurring correspondence between the first annotated image and the first thumbnail image corresponding to the first annotated image being displayed. In one embodiment, the method further comprises displaying the first thumbnail image in the second display area when one other image of the image sequence data is displayed in the first display area after the first annotated image is displayed.

Abstract: A method for presentation of image sequence data is disclosed. The intensity of the image sequence data is used to derive the navigation guide. Each representative data may correspond to an average pixel value, a median pixel value, a minimum value, or a maximum value of the sub-image or said one or more images. Each representative data may also comprise a term proportional to a mathematical product of adjusted color values. The series of representative data can be plotted along with highlighting an area between a curve corresponding to the series of representative data and a coordinate axis by filling the area with a highlight color. Each representative data may comprise a minimum value and a maximum value associated with the sub-image, or one or more images.

Abstract: A method and system for displaying images captured by an in vivo imaging device are disclosed. Embodiments according to the present invention display image sequence data in a first display area. When a first annotated image is displayed in the first display area, a first thumbnail image in a second display area corresponding to the first annotated image is replaced to indicate an occurring correspondence between the first annotated image and the first thumbnail image corresponding to the first annotated image being displayed. In one embodiment, the method further comprises displaying the first thumbnail image in the second display area when one other image of the image sequence data is displayed in the first display area after the first annotated image is displayed.

Abstract: A camera system uses one or more image sensor IC chips each having multiple pixel arrays on the same semiconductor substrate (i.e., “multiple pixel arrays on a chip”). In one embodiment, such a camera system includes: (a) optical components that create multiple images in close physical proximity of each other (e.g., within a few millimeters or centimeters); and (b) a single sensor substrate (“chip”) containing multiple 2-dimensional pixel arrays that are aligned to capture these multiple images, so as to convert the multiple images into electrical signal. The pixel arrays can be manufactured using a CCD or a CMOS compatible process. For manufacturing reasons, such a chip is typically two centimeters or less on a side. However, large chips can also be made. Optional electronic components for further signal processing of the captured images may be formed either on the sensor chip (i.e., in a “system-on-a-chip” implementation), or in a separate back-end application specific integrated circuit (ASIC).

Abstract: A capsule endoscopic system is disclosed, wherein the system comprises a capsule endoscope, a docking station, second circuits and contact means to cause the second circuits connected to first circuits inside the capsule endoscope when the capsule endoscope is docked in the docking station in a first rotational orientation and in a second rotational orientation. The capsule endoscope comprises a capsule housing, the first circuits, and first contacts disposed fixedly on or through the capsule housing, wherein the first contacts are connected to the first circuits. The docking station comprises one or more second contacts. The docking station also includes a docking bay to receive the capsule endoscope. The second contacts are configured to contact the first contacts and to cause the first circuits to connect to the second circuits when the capsule endoscope is docked in the first rotational orientation and the second rotational orientation.

Abstract: A capsule endoscopic system with wireless docking device is disclosed, where the system comprises a capsule device and a docking device for receiving the data from the capsule device. The docking device supplies power to the capsule device and retrieves data from the capsule device wirelessly. The capsule device comprises an archival memory to store data captured inside a body lumen by the capsule device, a wireless transmitter to transmit the stored data, a secondary coil. The docking device comprises a primary coil to generate an alternating magnetic field, wherein the magnetic field is coupled to the secondary coil to supply power to the capsule device wirelessly when the capsule device is docked in the docking device and a wireless receiver to receive the data from the capsule device. The wireless link can be a radio frequency (RF) link or an optical link.

Abstract: An in vivo endoscope illuminates tissue using multiple sources. Light from a short-range source exits a tubular wall of the endoscope through a first illumination region that overlaps an imaging region, and the light returns through the imaging region after reflection by tissue, to form an image in a camera. Light from a long-range source exits the tubular wall through a second illumination region that does not overlap the imaging region. The endoscope of some embodiments includes a mirror, and light from an emitter for the short-range source is split and reaches the first illumination region from both sides of an optical axis of the camera. Illuminating the first illumination region with split fractions of light results in greater uniformity of illumination, than illuminating directly with an un-split beam. The energy generated by each source is changed depending on distance of the tissue to be imaged.

Abstract: An in vivo endoscope illuminates tissue using multiple sources. Light from a short-range source exits a tubular wall of the endoscope through a first illumination region that overlaps an imaging region, and the light returns through the imaging region after reflection by tissue, to form an image in a camera. Light from a long-range source exits the tubular wall through a second illumination region that does not overlap the imaging region. The endoscope of some embodiments includes a mirror, and light from an emitter for the short-range source is split and reaches the first illumination region from both sides of an optical axis of the camera. Illuminating the first illumination region with split fractions of light results in greater uniformity of illumination, than illuminating directly with an un-split beam. The energy generated by each source is changed depending on distance of the tissue to be imaged.

Abstract: An in vivo endoscope illuminates tissue using multiple sources. Light from a short-range source exits a tubular wall of the endoscope through a first illumination region that overlaps an imaging region, and the light returns through the imaging region after reflection by tissue, to form an image in a camera. Light from a long-range source exits the tubular wall through a second illumination region that does not overlap the imaging region. The endoscope of some embodiments includes a mirror, and light from an emitter for the short-range source is split and reaches the first illumination region from both sides of an optical axis of the camera. Illuminating the first illumination region with split fractions of light results in greater uniformity of illumination, than illuminating directly with an un-split beam. The energy generated by each source is changed depending on distance of the tissue to be imaged.

Abstract: A capsule endoscopic system is disclosed for receiving data from a capsule device and providing inductive power to the capsule device wirelessly, where the capsule endoscopic system incorporates a feature to automatically protect the capsule device and the docking device from damage if the capsule device is docked in a backward orientation. In one embodiment, the docking device comprises a current sense circuit to detect the current flowing through the primary coil or primary drive circuit. The occurrence of wrong orientation can be detected from the current. A detection/control circuit can be used to provide the needed control in order to prevent damage to the system. In another embodiment, a resonant circuit comprising a capacitor and the primary coil is used to provide the needed protection when the capsule device is docked with a wrong orientation.

Abstract: A power source apparatus and a system incorporating said power source for medical capsules are disclosed. Embodiments of the present invention allow the medical capsule to enable/disable electrical power supplied to a sub-system in the capsule device without special tools and/or skills after the medical capsule is manufactured. In one embodiment, the power source apparatus comprises a plunger responsive to a magnetic field, a spring to interact with the plunger, a battery and a control piece. The plunger is moved between first and second positions according to a magnetic field applied externally. Accordingly, the control piece enables or disables the power depending on the plunger positions. In another embodiment, a capsule system uses an electrical interconnect with pressure contacts between the power source and the capsule sub-system connecting the second circuit board to the power-output nodes.

Abstract: A capsule device with an inductive powering apparatus is disclosed. The capsule device comprises a secondary coil to generate an induced secondary voltage when a first alternating magnetic field is coupled to the secondary coil externally. Embodiments of the present invention utilize a power conversion device to convert the induced secondary voltage into a DC output voltage for the capsule device. In particular, the power conversion device comprises a voltage booster to generate the DC voltage from a lower induced secondary voltage. Accordingly, the system can be operated using a lower secondary voltage, which will reduce the influence of magnetic flux on the circuit boards inside the capsule.

Abstract: An in-vivo self-assembly capsule system is disclosed, where the in-vivo capsule system comprises a first primary capsule, at least one second capsule, and a self-connection means for connecting the first primary capsule and said at least one second capsule by providing holding force when the first primary capsule and said at least one second capsule are in contact in human GI tract. The self-connection means comprises an interlocking means disposed on the first primary capsule and said at least one second capsule. The interlocking means may correspond to hooks disposed on one connecting side and loops disposed on another connecting side, or hooks disposed on both connecting sides. The interlocking means may also correspond to a first magnet and an interaction piece affixed to two corresponding capsules respectively, and the interaction piece corresponds to a second magnet or a ferromagnetic component.

Abstract: Systems and methods are provided for displaying images captured from a panoramic capsule camera system. In one embodiment according to the invention, multiple sub-image sets are generated using a sub-image set window on the panoramic image by cyclically shifting the panoramic image. The multiple sub-image sets are then displayed in multiple display windows. In another embodiment according to the invention, the sub-image set in every other display window is flipped horizontally, vertically or both horizontally and vertically.

Abstract: An in vivo endoscope illuminates tissue using multiple sources. Light from a short-range source exits a tubular wall of the endoscope through a first illumination region that overlaps an imaging region, and the light returns through the imaging region after reflection by tissue, to form an image in a camera. Light from a long-range source exits the tubular wall through a second illumination region that does not overlap the imaging region. The endoscope of some embodiments includes a mirror, and light from an emitter for the short-range source is split and reaches the first illumination region from both sides of an optical axis of the camera. Illuminating the first illumination region with split fractions of light results in greater uniformity of illumination, than illuminating directly with an un-split beam. The energy generated by each source is changed depending on distance of the tissue to be imaged.

Abstract: Method and system are provided for displaying images captured from a capsule camera system. In one embodiment of the present invention, annotation data associated with image sequence data is used to derive navigation guide for the images. The navigation guide comprises a series of part representations corresponding to the images, and wherein one color is selected for each of the series of part representations. In another embodiment of the present invention, the intensity of the image sequence data is used to derive the navigation guide, which comprises a series of intensity profiles corresponding to the images. Various ways to derive the intensity profile are disclosed.

Abstract: An in vivo endoscope illuminates tissue using multiple sources. Light from a short-range source exits a tubular wall of the endoscope through a first illumination region that overlaps an imaging region, and the light returns through the imaging region after reflection by tissue, to form an image in a camera. Light from a long-range source exits the tubular wall through a second illumination region that does not overlap the imaging region. The endoscope of some embodiments includes a mirror, and light from an emitter for the short-range source is split and reaches the first illumination region from both sides of an optical axis of the camera. Illuminating the first illumination region with split fractions of light results in greater uniformity of illumination, than illuminating directly with an un-split beam. The energy generated by each source is changed depending on distance of the tissue to be imaged.

Abstract: A method and system for displaying images captured by an in vivo imaging device are disclosed. Embodiments according to the present invention display image sequence data in a first display area. When a first annotated image is displayed in the first display area, a first thumbnail image in a second display area corresponding to the first annotated image is replaced to indicate an occurring correspondence between the first annotated image and the first thumbnail image corresponding to the first annotated image being displayed. In one embodiment, the method further comprises displaying the first thumbnail image in the second display area when one other image of the image sequence data is displayed in the first display area after the first annotated image is displayed.

Abstract: A capsule camera with on-board storage to archive the captured images in on-board non-volatile memory is disclosed. The capsule camera with on-board storage comprises multiple chips including a system processing chip and one or more non-volatile memory chips, where the system processing chip includes a compression module to compress images captured. If the multiple chips use individual chip packages and are disposed on respective printed circuit boards according to a conventional approach, it would require too much space to fit the multiple chips into the capsule camera housing. Accordingly, a capsule camera embodying the present invention is disclosed where the capsule camera integrates an image sensor, a light source, at least one system processing chip comprising compression module, one or more non-volatile memory chips and a battery into a housing, wherein the at least one system processing chip and said one or more non-volatile memory chips are disposed vertically in a multiple chip assembly.