Patents by Inventor Gordon L. Bundy

Gordon L. Bundy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridylamides of nitriloprostacyclins
    Patent number: 4163841
    Abstract: This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) wherein a nitrogen atom is substituted for the 6,9.alpha.-epoxy-oxygen of prostacyclin. These novel nitrogen-containing prostacyclin-type compounds are useful for the pharmacological purposes for which prostacyclin is used, e.g., as antithrombotic agents, antihypertensive agents, antiasthma agents, nasal decongestants, or regulators of fertility and procreation.
    Type: Grant
    Filed: April 5, 1978
    Date of Patent: August 7, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 11-Deoxy-2,2-difluoro-PGE compounds
    Patent number: 4163110
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: July 31, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • Cycloamides of nitriloprostacyclins
    Patent number: 4161584
    Abstract: This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) wherein a nitrogen atom is substituted for the 6,9.alpha.-epoxy-oxygen of prostacyclin. These novel nitrogen-containing prostacyclin-type compounds are useful for the pharmacological purposes for which prostacyclin is used, e.g., as antithrombotic agents, antihypertensive agents, antiasthma agents, nasal decongestants, or regulators of fertility and procreation.
    Type: Grant
    Filed: April 5, 1978
    Date of Patent: July 17, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-5-oxa-16-phenyl-PGF.sub.1 compounds
    Patent number: 4159385
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-5-oxa-16-phenyl-PGF.sub.1 compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-type compounds.
    Type: Grant
    Filed: July 12, 1978
    Date of Patent: June 26, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-13,14-didehydro-16-phenyl-PGF compounds
    Patent number: 4156782
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-13,14-didehydro-16-phenyl-PGF compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-type compounds.
    Type: Grant
    Filed: July 12, 1978
    Date of Patent: May 29, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-16,16-dimethyl-PGF.sub.2 compounds
    Patent number: 4156087
    Abstract: The present invention relates to novel 9-deoxy-16,16-dimethyl-PGF.sub.2 compounds, which are prostaglandin analogs useful for the same pharmacological purposes as the corresponding prostaglandins. In particular, the instant compounds are particularly and especially useful as gastric anti-ulcer agents and are useful in stimulating the pregnant mammalian uterus.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: May 22, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl-PGD compounds
    Patent number: 4154764
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: May 15, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 11-Deoxy-17-phenyl-13,14-dihydro-PGE.sub.1 compounds
    Patent number: 4152523
    Abstract: This invention comprises 11-deoxy-17-phenyl-18,19,20-trinor-prostaglandin-type compounds which exhibit prostaglandin-type pharmacological activity, such as lowering blood pressure, inhibiting gastric secretion, regulating the reproductive cycle, and the like.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: May 1, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 9.alpha.,5-Nitrilo-9-deoxy-PGF.sub.1 compounds
    Patent number: 4152514
    Abstract: This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) wherein a nitrogen atom is substituted for the 6,9.alpha.-epoxy-oxygen of prostacyclin. These novel nitrogen-containing prostacyclin-type compounds are useful for the pharmacological purposes for which prostacyclin is used, e.g., as antithrombotic agents, antihypertensive agents, antiasthma agents, nasal decongestants, or regulators of fertility and procreation.
    Type: Grant
    Filed: April 5, 1978
    Date of Patent: May 1, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Bioprecursors of 9-deoxy-6,9.alpha.-nitrilo-PGF.sub.1
    Patent number: 4151176
    Abstract: The present invention relates to novel bioprecursors for prostaglandin analogs of the formula ##STR1## These bioprecursors are useful for the same pharmacological purposes as the corresponding prostaglandin analogs, being hydrolyzable thereto in vivo.
    Type: Grant
    Filed: May 30, 1978
    Date of Patent: April 24, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl-3,7-inter- m-phenylene-3-oxa-4,5,6-trinor-9-deoxy-9,10-didehydro-PGD.sub.1 compounds
    Patent number: 4151206
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: April 24, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 11-Deoxy-17-phenyl-13,14-dihydro-PGE.sub.2 compounds
    Patent number: 4151359
    Abstract: This invention comprises 11-deoxy-17-phenyl-18,19,20-trinor-prostaglandin-type compounds which exhibit prostaglandin-type pharmacological activity, such as lowering blood pressure, inhibiting gastric secretion, regulating the reproductive cycle, and the like.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: April 24, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 2-Decarboxy-2-alkylcarbonyl-3,7-inter-m-phenylene-3-oxa-4,5,6- trinor-9-deoxy-9-methylene PGF.sub.1 compounds
    Patent number: 4150056
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: April 17, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl PGD compounds
    Patent number: 4148827
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: April 10, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl-3,7-inter-m-phenylene-3-oxa-4,5,6-trinor-PGA or PGB compounds
    Patent number: 4148828
    Abstract: The present invention provides a novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: April 10, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl-11-deoxy-PGF compounds
    Patent number: 4148825
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: April 10, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl-PGA or PGB compounds
    Patent number: 4146561
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: March 27, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-hydroxymethyl-9-deoxy-9-methylene-16-phenyl-PGF compounds
    Patent number: 4145561
    Abstract: The present invention relates to novel 2-decarboxy-2-hydroxymethyl-9-deoxy-9-methylene-16-phenyl-PGF compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-type compounds.
    Type: Grant
    Filed: July 12, 1978
    Date of Patent: March 20, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-PFG.sub.1 -piperidylamides
    Patent number: 4145534
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-PGF.sub.1 -piperidylamides. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding 9-deoxy-9-methylene-PGF-type acids.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: March 20, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • PG-type, 1,9-lactones
    Patent number: RE30053
    Abstract: The present invention provides novel 1,9 lactones of prostaglandin-type free acids and a process for their preparation. These lactones are useful for the same pharmacological purposes as the corresponding prostaglandin-type free acids.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: July 24, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy