Patents by Inventor Gordon L. Bundy

Gordon L. Bundy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-Decarboxy-2-alkylcarbonyl-9-deoxy-9,10-didehydro-PGD compounds
    Patent number: 4145365
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: March 20, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl-11-deoxy-PGE compounds
    Patent number: 4144274
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: March 13, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl-3,7-inter -m-phenylene-3-oxa-4,5,6-trinor-11-deoxy-PGF.sub.1 compounds
    Patent number: 4144273
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: March 13, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 3,7-Inter-phenylene-4,5 ,6-trinor-3-oxa-2-decarboxy-2-hydroxymethyl-9-deoxy-9-methylene-PGF-type compounds
    Patent number: 4144276
    Abstract: This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: March 13, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-PGF-type lactones
    Patent number: 4144253
    Abstract: This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: September 12, 1977
    Date of Patent: March 13, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 2-Decarboxy-2-alkylcarbonyl-3,7-inter-m-phenylene-3-oxa-4,5,6-tri nor-11-deoxy-PGE.sub.1 compounds
    Patent number: 4141918
    Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: February 27, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 11-Deoxy-cis-4,5-didehydro-.omega.-aryl-PGF compounds
    Patent number: 4138577
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 11-Deoxy-2,2-difluoro-.omega.-aryl-PGE compounds
    Patent number: 4138573
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 11-Deoxy-2,2-difluoro-.omega.-aryl-PGF compounds
    Patent number: 4138576
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 11-Deoxy-16-phenoxy-PGF compounds
    Patent number: 4138575
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 9-Deoxy-9-methylene-16-phenyl-17,18,19,20-tetranor- 5,6,13,14-tetradehydro-4,4,5,5,13,14-hexadehydro-pgf.sub.1 compounds
    Patent number: 4138578
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-16-phenyl-17,18,19,20-tetranor-5,6,13,14-tetradehydro- 4,4,5,5,13,14-hexadehydro-PGF.sub.1 compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-type compounds.
    Type: Grant
    Filed: July 12, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-PGF.sub.2 cycloamides
    Patent number: 4137403
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-PGF.sub.2 cycloamides. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding 9-deoxy-9-methylene-PGF-type acids.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: January 30, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 5,9.alpha.-Imino- or 6,9.alpha.-iminomethylene-9-deoxy-PGF.sub.1 compounds
    Patent number: 4136095
    Abstract: This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) wherein a nitrogen is substituted for the 6,9.alpha.-epoxy-oxygen of prostacyclin. These novel nitrogen-containing prostacyclin-type compounds are useful for the pharmacological purposes for which prostacyclin is used, e.g., as antithrombotic agents, antihypertensive agents, antiasthma agents, nasal decongestants, or regulators of tertility and procreation.
    Type: Grant
    Filed: April 5, 1978
    Date of Patent: January 23, 1979
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-PGF-p-substituted phenyl esters
    Patent number: 4130720
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-p-substituted phenyl esters. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding 9-deoxy-9-methylene-PGF-type acids.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: December 19, 1978
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-PGF sulfonylamides
    Patent number: 4130584
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-PGF-sulfonylamides. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding 9-deoxy-9-methylene-PGF-type acids.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: December 19, 1978
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 11-Deoxy PGE.sub.2 compounds
    Patent number: 4130721
    Abstract: 11-Deoxyprostaglandin E and F type compounds, i.e. prostaglandin E and F type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: July 24, 1972
    Date of Patent: December 19, 1978
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 9-Deoxy-9-methylene-PGF.sub.1 -pyrrolinylamides
    Patent number: 4129725
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-PGF.sub.1 -pyrrolinylamides. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding 9-deoxy-9-methylene-PGF-type acids.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: December 12, 1978
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-PGF.sub.1 -piperizinylamides
    Patent number: 4129726
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-PGF.sub.1 -piperizinylamides. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding 9-deoxy-9-methylene-PGF-type acids.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: December 12, 1978
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-PGF.sub.1 -pyrrolidylamides
    Patent number: 4129727
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-PGF.sub.1 -pyrrolidylamides. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding 9-deoxy-9-methylene-PGF-type acids.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: December 12, 1978
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 9-Deoxy-9-methylene-PGF-3,4-didehydropiperidylamides
    Patent number: 4129724
    Abstract: The present invention relates to novel 9-deoxy-9-methylene-PGF ,3,4-didehydropiperidylamides. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding 9-deoxy-9-methylene-PFG-type acids.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: December 12, 1978
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy