Patents by Inventor Gordon M. Keller

Gordon M. Keller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR MAKING AND USING ENDOCARDIAL CELLS
    Publication number: 20230265391
    Abstract: Methods and compositions for making endocardial cells from pluripotent stem cells are described, as are methods and compositions for using such cells.
    Type: Application
    Filed: May 7, 2021
    Publication date: August 24, 2023
    Inventors: Gordon M. Keller, Alexander Mikryukov, Amine Mazine, Ian Fernandes
  • USE OF CD34 AS A MARKER FOR SINOATRIAL NODE-LIKE PACEMAKER CELLS
    Publication number: 20230167411
    Abstract: The invention relates to the use of CD34 as a cell surface marker to detect sinoatrial node-like pacemaker cells (SANLPCs) in a population of cells and to generate cell preparations highly enriched for SANLPCs. Also provides herein are methods of using SANLPC-enriched cell preparations for cardiac cell therapy.
    Type: Application
    Filed: April 30, 2021
    Publication date: June 1, 2023
    Inventors: Stephanie I. Protze, Gordon M. Keller, Michelle Lohbihler, Amos Chun-Hin Adrian Lim
  • Cardiomyocyte Compositions and Use Thereof
    Publication number: 20220228120
    Abstract: Provided herein are enriched populations of ventricular compact cardiomyocytes and enriched populations of mature ventricular or atrial cardiomyocytes, as well as methods of generating the enriched cell populations and methods of using the enriched cell populations in regenerative cardiac cell therapies.
    Type: Application
    Filed: May 4, 2020
    Publication date: July 21, 2022
    Applicants: UNIVERSITY HEALTH NETWORK, BlueRock Therapeutics LP
    Inventors: Gordon M. Keller, Shunsuke Funakoshi, lan Fernandes, Donghe Yang, Dan Charles Wilkinson, Jr.
  • Human cardiovascular progenitor cells
    Patent number: 10947506
    Abstract: The present invention provides populations of human cardiovascular progenitor cells, methods of making such cells, and methods of using the cells for production of populations of cardiovascular colonies and populations of cardiomyocytes. Methods of cardiomyocytes replacement therapy are also provided.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: March 16, 2021
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Gordon M. Keller, Lei Yang, Steven Kattman
  • Mesoderm and definitive endoderm cell populations
    Patent number: 10428308
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: October 1, 2019
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Gordon M. Keller, Paul Gadue
  • HUMAN CARDIOVASCULAR PROGENITOR CELLS
    Publication number: 20180362931
    Abstract: The present invention provides populations of human cardiovascular progenitor cells, methods of making such cells, and methods of using the cells for production of populations of cardiovascular colonies and populations of cardiomyocytes. Methods of cardiomyocytes replacement therapy are also provided.
    Type: Application
    Filed: August 9, 2018
    Publication date: December 20, 2018
    Inventors: Gordon M. Keller, Lei Yang, Steven Kattman
  • MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS
    Publication number: 20180155681
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Application
    Filed: August 28, 2017
    Publication date: June 7, 2018
    Inventors: Gordon M. Keller, Paul Gadue
  • STEM CELL GENE TARGETING
    Publication number: 20170298384
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 19, 2017
    Inventors: Gordon M. Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS
    Publication number: 20150315543
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Application
    Filed: August 25, 2014
    Publication date: November 5, 2015
    Inventors: Gordon M. Keller, Paul Gadue
  • MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS
    Publication number: 20150218512
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: February 26, 2015
    Publication date: August 6, 2015
    Inventors: Gordon M. Keller, Valerie Kouskoff, Atsushi Kubo, Hans J. Fehling
  • MESENDODERM AND MESODERM CELL POPULATIONS
    Publication number: 20140287494
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: December 17, 2013
    Publication date: September 25, 2014
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Gordon M. Keller, Valerie Kouskoff, Atsushi Kubo, Hans J. Fehling
  • Mesoderm and definitive endoderm cell populations
    Patent number: 8815591
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: August 26, 2014
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Gordon M. Keller, Paul Gadue
  • Cell population enriched for endoderm cells
    Patent number: 8748171
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: June 10, 2014
    Assignee: Mount Sinai School of Medicine
    Inventors: Gordon M Keller, Valerie Kouskoff, Atsushi Kubo, Hans Joerg Fehling
  • Mesoderm and definitive endoderm cell populations
    Patent number: 8283168
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: October 9, 2012
    Assignee: Mount Sinai School of Medicine
    Inventors: Gordon M. Keller, Paul Gadue
  • DEFINITIVE ENDODERM CELL POPULATIONS
    Publication number: 20120114613
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: July 14, 2010
    Publication date: May 10, 2012
    Applicant: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
    Inventors: GORDON M. KELLER, VALERIE KOUSKOFF, ATSUSHI KUBO, HANS JOERG FEHLING
  • Method for identification of cell growth or differentiation factors
    Patent number: 8143059
    Abstract: The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay to identify regulatory compounds capable of controlling cell growth for therapeutic and experimental use.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: March 27, 2012
    Assignee: National Jewish Health
    Inventors: Gordon M. Keller, Robert G. Hawley, Kyunghee Choi
  • Mesoderm and Definitive Endoderm Cell Populations
    Publication number: 20110212061
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Application
    Filed: June 23, 2006
    Publication date: September 1, 2011
    Applicant: Mount Sinai School of Medicine of New York University
    Inventors: Gordon M. Keller, Paul Gadue
  • Method of enriching a mammalian cell population for mesoderm cells
    Patent number: 7955849
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: June 7, 2011
    Assignee: Mount Sinai School of Medicine
    Inventors: Gordon M. Keller, Valerie Kouskoff, Atsushi Kubo, Hans Joerg Fehling
  • MESENDODERM AND MESODERM CELL POPULATIONS
    Publication number: 20110070203
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: July 14, 2010
    Publication date: March 24, 2011
    Applicant: Mount Sinai School of Medicine of New York University
    Inventors: Gordon M. Keller, Valerie Kouskoff, Atsushi Kubo, Hans Joerg Fehling
  • Mesoderm and definitive endoderm cell populations
    Patent number: 7763466
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: July 27, 2010
    Assignee: Mount Sinai School of Medicine of New York University
    Inventors: Gordon M. Keller, Valerie Kouskoff, Atsushi Kubo, Hans Joerg Fehling