Patents by Inventor Govind Rao

Govind Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240318121
    Abstract: The present invention provides for systems and method for noninvasive measurement and monitoring of cell culture parameters including dissolved oxygen (DO), dissolved carbon dioxide (DCO2), and pH wherein there is no direct contact with the cell culture environment which is achieved by conducting the measurements and monitoring on the outside of the bioreactor through semi-permeable membranes incorporated into the system to enhance the process and eliminate the risk of contamination associated with invasive sensors.
    Type: Application
    Filed: May 20, 2024
    Publication date: September 26, 2024
    Inventors: Govind RAO, Vida Rahmatnejad, Xudong Ge, Vikash Kumar, Michael Tolosa
  • Publication number: 20240035974
    Abstract: A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
    Type: Application
    Filed: October 13, 2023
    Publication date: February 1, 2024
    Inventors: Govind RAO, Yordan KOSTOV, Mustafa AL-ADHAMI, Chandrasekhar GURRAMKONDA
  • Publication number: 20230407230
    Abstract: The present invention relates to cell free protein manufacturing, and more particularly, for integrating machine learning into a portable cell-free bioprocessing system for producing proteins with increased and consistent purity, potency and quality wherein such proteins are prepared on-demand and for point-of-care delivery.
    Type: Application
    Filed: June 5, 2023
    Publication date: December 21, 2023
    Inventors: GOVIND RAO, YORDAN KOSTOV, BENJAMIN PUNSHON-SMITH, RAJANI ADIGA
  • Publication number: 20230407221
    Abstract: The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.
    Type: Application
    Filed: September 11, 2023
    Publication date: December 21, 2023
    Inventors: GOVIND RAO, YORDAN KOSTOV, ABHAY ANDAR, MUSTAFA AL-ADHAMI, SEVDA DELDARI, DOUGLAS D. FREY
  • Patent number: 11788962
    Abstract: A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: October 17, 2023
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Govind Rao, Yordan Kostov, Mustafa Al-Adhami, Chandrasekhar Gurramkonda
  • Publication number: 20230323488
    Abstract: The present invention relates to the use of a condensate collector such as portable or stationary dehumidifier placed in a defined testing space or area and used as a readily available and affordable tool to collect airborne virus particles in collected condensate from the testing atmosphere in the defined testing space or area, wherein the collected condensate is analyzed for virus biomarkers to identify viruses, such as SARS-CoV-2 or mutants or variants thereof, in the testing atmosphere.
    Type: Application
    Filed: April 11, 2023
    Publication date: October 12, 2023
    Inventors: Govind RAO, Xudong GE, Douglas D. FREY, Sai Sathish RAMAMURTHY, Dipanjan PAN
  • Publication number: 20230323277
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: June 6, 2023
    Publication date: October 12, 2023
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
  • Publication number: 20230243815
    Abstract: An automatic and continuous glucose monitoring apparatus and method of using same based on binding proteins. The apparatus integrates an aseptic sampling technique, a specially modified chromatography column to hold immobilized binding protein, and a microfluorometer into a compact portable device. The apparatus permits the measurement of a very wide range of concentrations—from a few micromolar to several hundreds of millimolar of glucose.
    Type: Application
    Filed: May 21, 2021
    Publication date: August 3, 2023
    Inventors: Leah Tolosa CROUCHER, Govind RAO, Xudong GE, Abhay ANDAR, Hasibul HASAN, Sheniqua BROWN, Yordan KOSTOV, Chad SUNDBERG, Vikash KUMAR, Shayan BORHANI, Sarah BURNEY, Samyukta RAO
  • Patent number: 11708553
    Abstract: The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: July 25, 2023
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Abhay Andar, Mustafa Al-Adhami, Sevda Deldari, Douglas D. Frey
  • Patent number: 11702625
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: July 18, 2023
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey
  • Patent number: 11685892
    Abstract: The present invention relates to cell free protein manufacturing, and more particularly, for integrating machine learning into a portable cell-free bioprocessing system for producing proteins with increased and consistent purity, potency and quality wherein such proteins are prepared on-demand and for point-of-care delivery.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: June 27, 2023
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Benjamin Punshon-Smith, Rajani Adiga
  • Publication number: 20220298469
    Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
    Type: Application
    Filed: June 10, 2022
    Publication date: September 22, 2022
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Kevin TRAN, Monohar Pilli, Michael TOLOSA, Chandrashekar Gurramkonda, Xudong GE, Douglas Frey
  • Patent number: 11308053
    Abstract: A system and method for loading data into column-partitioned database tables. The system and method incorporate a mechanism for buffering data extracted from the rows of a source table in column-oriented fashion within an in-buffer memory, enabling an efficient bulk-write of large arrays of values from the buffer into column-partitioned database tables. The system and method may also include optimizations for grouping columns according to data types and altering the order in which columns are inserted into the database tables.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: April 19, 2022
    Assignee: Teradata US, Inc.
    Inventors: Rui Zhang, Sanjay Nair, Paul Laurence Sinclair, Mamatha Govind Rao
  • Publication number: 20210380915
    Abstract: The present invention relates to collapsible and/or foldable fermentation and/or culture vessels fabricated of an adjustable frame including sections of gas permeable material or in the alternative a non-rigid gas permeable polymeric container or bag fabricated of either a gas permeable or non-gas permeable material with the further benefit of more efficient inventory space and disposal space, wherein the gas permeable material or non-gas permeable material comprises an analyte or pH sensing material integrated or impregnated into at least one section of the material.
    Type: Application
    Filed: August 20, 2021
    Publication date: December 9, 2021
    Inventors: GOVIND RAO, YORDAN KOSTOV, MICHAEL TOLOSA, XUDONG GE, VIKASH KUMAR, Vida Rahmatnejad
  • Publication number: 20210340488
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: July 15, 2021
    Publication date: November 4, 2021
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
  • Publication number: 20210252507
    Abstract: A microfluidic device and method of using same to separate whole blood into at least a plasma serum fraction and a red blood cell-containing fraction. The microfluidic device uses the principle of sedimentation and the different densities of the cells relative to the plasma serum to separate whole blood into at least the two fractions.
    Type: Application
    Filed: February 16, 2021
    Publication date: August 19, 2021
    Inventors: Mustafa AL-ADHAMI, Yordan KOSTOV, Govind RAO
  • Publication number: 20210223177
    Abstract: A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
    Type: Application
    Filed: January 25, 2021
    Publication date: July 22, 2021
    Inventors: Govind RAO, Yordan KOSTOV, Mustafa AL-ADHAMI, Chandrasekhar GURRAMKONDA
  • Publication number: 20210214664
    Abstract: The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.
    Type: Application
    Filed: June 7, 2018
    Publication date: July 15, 2021
    Inventors: GOVIND RAO, YORDAN KOSTOV, ABHAY ANDAR, MUSTAFA AL-ADHAMI
  • Publication number: 20210189322
    Abstract: The present invention relates to cell free protein manufacturing, and more particularly, for integrating machine learning into a portable cell-free bioprocessing system for producing proteins with increased and consistent purity, potency and quality wherein such proteins are prepared on-demand and for point-of-care delivery.
    Type: Application
    Filed: May 15, 2019
    Publication date: June 24, 2021
    Inventors: GOVIND RAO, YORDAN KOSTOV, BENJAMIN PUNSHON-SMITH, RAJANI ADIGA
  • Patent number: 10948414
    Abstract: A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: March 16, 2021
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Govind Rao, Yordan Kostov, Mustafa Al-Adhami, Chandrasekhar Gurramkonda