Patents by Inventor Govind Rao

Govind Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200095534
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: October 23, 2019
    Publication date: March 26, 2020
    Inventors: GOVIND RAO, YORDAN KOSTOV, LEAH TOLOSA, XUDONG GE, DOUGLAS FREY, SHAYAN GHOLIPOUR BORHANI, DAVID BURGENSON
  • Publication number: 20190330586
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 31, 2019
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
  • Patent number: 10435664
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: October 8, 2019
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey
  • Publication number: 20180348131
    Abstract: A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
    Type: Application
    Filed: June 6, 2018
    Publication date: December 6, 2018
    Inventors: Govind RAO, Yordan KOSTOV, Mustafa AL-ADHAMI, Chandrasekhar GURRAMKONDA
  • Publication number: 20180298325
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: April 30, 2018
    Publication date: October 18, 2018
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
  • Patent number: 9982227
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 29, 2018
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey
  • Patent number: 9883823
    Abstract: Systems and methods for determining an in vivo concentration of a small molecule substance of interest is provided that takes advantage of the semi-permeable nature of skin, which allows small molecules to passively diffuse through the skin and onto the skin surface. The systems and methods of the present invention allow for the collection of these small molecules that have passively diffused through the skin without skin disruption or breaking of the skin. The systems and methods of the present invention are noninvasive, painless and safe even for delicate newborns, and are particularly suited for the determination of blood glucose in newborns and infants in a noninvasive manner.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: February 6, 2018
    Assignee: University of Maryland Baltimore County
    Inventors: Leah Tolosa, Xudong Ge, Yordan Kostov, Michael Tolosa, Govind Rao
  • Publication number: 20170226467
    Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
    Type: Application
    Filed: July 31, 2015
    Publication date: August 10, 2017
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Kevin Tran, Monohar Pilli, Michael Tolosa, Chandrashekar Gurramkonda
  • Publication number: 20170212048
    Abstract: An analyte sensing system is provided that utilizes separate and decoupled equilibrium and measurement chambers for improved sensitivity and stability. The system and method are particularly suited for monitoring of CO2 levels in oceans or other bodies of water.
    Type: Application
    Filed: September 30, 2011
    Publication date: July 27, 2017
    Inventors: Govind RAO, Yordan KOSTOV, Xudong GE, Leah TOLOSA, Hung LAM, Robert HENDERSON
  • Publication number: 20170116237
    Abstract: A system and method for loading data into column-partitioned database tables. The system and method incorporate a mechanism for buffering data extracted from the rows of a source table in column-oriented fashion within an in-buffer memory, enabling an efficient bulk-write of large arrays of values from the buffer into column-partitioned database tables. The system and method may also include optimizations for grouping columns according to data types and altering the order in which columns are inserted into the database tables.
    Type: Application
    Filed: October 27, 2016
    Publication date: April 27, 2017
    Applicant: Teradata US, Inc.
    Inventors: Rui Zhang, Sanjay Nair, Paul Laurence Sinclair, Mamatha Govind Rao
  • Patent number: 9560974
    Abstract: A noninvasive remote parameter sensor and sensing method is provided that is particularly suited for the remote monitoring of skin temperature. The sensor and sensing method utilize luminescence-based sensors that are non-toxic and non-irritating to the skin. The sensor preferably utilizes one or more types of fluorophores that are embedded in a soft hydrogel. The sensor is illuminated with excitation light, and temperature is monitored by detecting and analyzing the emission light from the fluorophores. Because a soft hydrogel is used, the sensor can be gently wiped off the skin at the conclusion of temperature measurements.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: February 7, 2017
    Assignee: University of Maryland Baltimore County
    Inventors: Leah Tolosa, Hung Lam, Yordan Kostov, Steven M Falk, Govind Rao
  • Patent number: 9538944
    Abstract: A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: January 10, 2017
    Assignee: University of Maryland Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Xudong Ge, Leah Tolosa, Hyung Woo, Rose Viscardi
  • Publication number: 20160348048
    Abstract: A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.
    Type: Application
    Filed: May 27, 2016
    Publication date: December 1, 2016
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Hung LAM, Xudong GE, Douglas FREY, Virendra SINGH
  • Publication number: 20160222341
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: April 11, 2016
    Publication date: August 4, 2016
    Inventors: GOVIND RAO, YORDAN KOSTOV, LEAH TOLOSA, XUDONG GE, DOUGLAS FREY
  • Patent number: 9388373
    Abstract: A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: July 12, 2016
    Assignee: University of Maryland Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Lam Hung, Xudong Ge, Douglas Frey, Virendra Singh
  • Publication number: 20150093775
    Abstract: An analyte sensing and monitoring system and method is provided that is particularly applicable to monitoring of analytes in cell cultures. The system and method relies on the initial diffusion rates of the analytes from the medium that contains the analytes being measured (e.g., cell culture) into a diffusion chamber that is inserted into the medium, and remote sensing of the analytes using an analyte sensing system that is coupled to the diffusion chamber.
    Type: Application
    Filed: July 2, 2014
    Publication date: April 2, 2015
    Inventors: Govind RAO, Xudong GE, Yordan KOSTOV, Madhubanti CHATTERJEE, Leah TOLOSA, Shaunak Dilip UPLEKAR, Manohar PILLI
  • Patent number: 8993972
    Abstract: A fluorescence based sensor system that provides improved signal-to-noise over prior systems is provided. The system includes a fluorescence based sensing medium that is contained a recessed cavity with reflective sides that allow for more uniform excitation of the fluorescence based sensing medium by the excitation light.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: March 31, 2015
    Assignee: University of Maryland Baltimore County
    Inventors: Govind Rao, Hung Lam, Yordan Kostov, Leah Tolosa, Xudong Ge
  • Publication number: 20150010994
    Abstract: A system and method for measuring at least one bioprocess parameter utilizes a barrier that separates an external sensor from a culture medium. The barrier allows analytes to diffuse in and out of the culture vessel, thereby allowing the bioprocess parameter to be measured non-invasively by the external sensor.
    Type: Application
    Filed: June 10, 2014
    Publication date: January 8, 2015
    Applicant: University of Maryland Baltimore County
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA
  • Patent number: 8852921
    Abstract: A system and method for measuring at least one bioprocess parameter utilizes a barrier that separates an external sensor from a culture medium. The barrier allows analytes to diffuse in and out of the culture vessel, thereby allowing the bioprocess parameter to be measured non-invasively by the external sensor.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: October 7, 2014
    Assignee: University of Maryland Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa
  • Patent number: 8654319
    Abstract: A low cost sensing system that can measure both chlorophyll concentration and turbidity is provided. The system is an optical system that utilizes at least three light sensors for measuring side-scattered and forward scattered light, as well as fluorescence. The system is able to take optical density measurements, steady state fluorescence measurements and maximum fluorescence measurements, and can be configured for wireless control and data transmission. The system may also be housed in one or more fluidtight housings so as to make it submersible.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: February 18, 2014
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Hung Lam, Yordan Kostov, Leah Tolosa, Xudong Ge