Patents by Inventor Grace Lee
Grace Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240110240Abstract: The disclosure provides compositions, methods, and systems for implementation of highly multiplexed molecular diagnostic assays involving color combinatorics, stimulus-responsive probes, tandem probes, conjugated polymer probes, and other mechanisms for increasing the number of targets that can be simultaneously detected in a digital assay. Multiplexed detection of targets is achieved in a rapid manner, with respect to sample partitioning and target detection using multiple color channels for detection. Implementation of methods described also achieve detection with significantly improved signal-to-noise ratio (SNR) values.Type: ApplicationFiled: October 5, 2023Publication date: April 4, 2024Inventors: Eleen Yee Lam SHUM, Hei Mun Christina FAN, Stephen P.A. FODOR, Janice Hoiyi LAI, Jung Won KEUM, Haeun Grace LEE
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Publication number: 20240091300Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.Type: ApplicationFiled: November 10, 2023Publication date: March 21, 2024Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Gong CHEN, Gang-Yi WU, Lei ZHANG, Jiu-Chao YIN, Hana YEH, Ning-Xin MA, Grace LEE
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Publication number: 20240004414Abstract: This invention relates to a method and apparatus for power factor adjustment in a waveguide circuit or a transmission line circuit. In this invention, it is shown that, in a waveguide circuit or a transmission line circuit, the power supplied by the source and the impedance can be adjusted by controlling the amount of the phase change of the signal when it propagates through the (equivalent) transmission line once the medium, the structure, and the load of the waveguide circuit or the transmission line circuit are chosen. It is also shown that, by choosing an appropriate frequency, transmission line, and load, one can achieve the negative power factor of the (equivalent) transmission line circuit, and also make the power delivered from the source be lesser than that consumed at the load.Type: ApplicationFiled: March 27, 2020Publication date: January 4, 2024Inventors: Aquila Hwan LEE, Eunhye Grace LEE, Younghye Gloria LEE, Inhye LEE, Won Don LEE, Hijung CHAI
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Patent number: 11850273Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG; purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.Type: GrantFiled: August 9, 2021Date of Patent: December 26, 2023Assignee: The Penn State Research FoundationInventors: Gong Chen, Gang-Yi Wu, Lei Zhang, Jiu-Chao Yin, Hana Yeh, Ning-Xin Ma, Grace Lee
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Patent number: 11834714Abstract: The disclosure provides compositions, methods, and systems for implementation of highly multiplexed molecular diagnostic assays involving color combinatorics, stimulus-responsive probes, tandem probes, conjugated polymer probes, and other mechanisms for increasing the number of targets that can be simultaneously detected in a digital assay. Multiplexed detection of targets is achieved in a rapid manner, with respect to sample partitioning and target detection using multiple color channels for detection. Implementation of methods described also achieve detection with significantly improved signal-to-noise ratio (SNR) values.Type: GrantFiled: December 20, 2022Date of Patent: December 5, 2023Assignee: ENUMERIX, INC.Inventors: Eleen Yee Lam Shum, Hei Mun Christina Fan, Stephen P. A. Fodor, Janice Hoiyi Lai, Jung Won Keum, Haeun Grace Lee
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Publication number: 20230193385Abstract: The disclosure provides compositions, methods, and systems for implementation of highly multiplexed molecular diagnostic assays involving color combinatorics, stimulus-responsive probes, tandem probes, conjugated polymer probes, and other mechanisms for increasing the number of targets that can be simultaneously detected in a digital assay. Multiplexed detection of targets is achieved in a rapid manner, with respect to sample partitioning and target detection using multiple color channels for detection. Implementation of methods described also achieve detection with significantly improved signal-to-noise ratio (SNR) values.Type: ApplicationFiled: December 20, 2022Publication date: June 22, 2023Inventors: Eleen Yee Lam SHUM, Hei Mun Christina FAN, Stephen P.A. FODOR, Janice Hoiyi LAI, Jung Won KEUM, Haeun Grace LEE
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Publication number: 20230074085Abstract: This disclosure provides for devices, methods, and systems for performing a non-invasive prenatal testing (NIPT) digital assay upon generating at least a large number of counts per chromosome for a set of chromosomes present in a sample, where performing the NIPT digital assay can include: distributing nucleic acids of the sample and materials for an amplification reaction across a plurality of partitions; amplifying the nucleic acids with the materials, within the plurality of partitions; and generating counts per chromosome upon detecting signals from the plurality of partitions. The inventions enable processing of samples for NIPT digital analyses and/or other digital analyses involving other loci of interest, with unprecedented partitioning, reaction, readout, and analytical performance.Type: ApplicationFiled: September 7, 2022Publication date: March 9, 2023Inventors: Eleen Yee Lam Shum, Hei Mun Christina Fan, Stephen P. A. Fodor, Haeun Grace LEE
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Publication number: 20210369808Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG; purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.Type: ApplicationFiled: August 9, 2021Publication date: December 2, 2021Inventors: Gong CHEN, Gang-Yi WU, Lei ZHANG, Jiu-Chao YIN, Hana YEH, Ning-Xin MA, Grace LEE
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Patent number: 11161882Abstract: The disclosure relates to the identification, cloning, and expression of a genetic locus within a Listeria monocytogenes genome that encodes a phage tail-like bacteriocin (PTLB), termed a monocin. Also provided are non-natural monocins, which have been engineered to have altered bactericidal specificity. Nucleic acid molecules encoding natural or non-natural monocins, vector constructs containing such nucleic acids operably linked to a heterologous promoter, producer cells containing such vectors, the encoded monocins, as well as methods of making and using such monocins are described.Type: GrantFiled: November 6, 2015Date of Patent: November 2, 2021Assignee: PYLUM BIOSCIENCES, INC.Inventors: Urmi Chakraborty, Grace Lee, Dean Scholl
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Patent number: 11141757Abstract: A fitting tube structure of a glue gun contains: a conical connection part, an accommodation chamber, a feeding segment, and an open segment. The fitting assembly includes a first fixing tube, an O ring, a second fixing tube, a stop sleeve, a locating ring, and a coupling tube. The first fixing tube has a stepped portion. The O ring is retained between the stepped portion and the second fixing tube. The stop sleeve is fitted on the first fixing tube and has a large-diameter extension and a small-diameter extension, and the large-diameter extension covers the first fixing tube and is fitted on the large-diameter extension by using the locating ring. The coupling tube is fixed on the small-diameter extension. Furthermore, the first fixing tube, the second fixing tube, and the stop sleeve are fitted and are fixed by the locating ring and the coupling tube.Type: GrantFiled: December 4, 2020Date of Patent: October 12, 2021Assignee: HOMEEASE INDUSTRIAL CO., LTD.Inventor: Grace Lee
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Patent number: 11116815Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.Type: GrantFiled: September 30, 2019Date of Patent: September 14, 2021Assignee: The Penn State Research FoundationInventors: Gong Chen, Gang-Yi Wu, Lei Zhang, Jiu-Chao Yin, Hana Yeh, Ning-Xin Ma, Grace Lee
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Patent number: 10906969Abstract: Methods of treating acute thyroid eye disease (TED) by administering a inhibitor, e.g., a VEGF-A inhibitor, e.g., an anti-VEGF antibody, optionally in combination with hyaluronidase, by periorbital or intraorbital injection. Also compositions comprising a VEGF inhibitor and hyaluronidase.Type: GrantFiled: June 8, 2017Date of Patent: February 2, 2021Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.Inventors: N. Grace Lee, Leo Kim, Patricia A. D'Amore, James A. Stefater
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Publication number: 20200078819Abstract: An improved hot melt glue gun with an automatic glue stick feeding structure includes a housing that is gun-shaped and that includes an inlet and an outlet. A glue stick feeding module is mounted in the housing and located adjacent to the inlet. The glue stick feeding module includes a motor connected to a casing. The casing includes a passage and a through-hole. The passage is located in the casing and intercommunicates with the inlet. The through-hole is aligned with the passage in a transverse direction. An activation module includes an activation rod reciprocatingly and movably extending through the through-hole. A micro switch is located adjacent to the activation module and is electrically connected to the motor. The micro switch is configured to be pressed by the activation rod to activate the motor. A hot melt module is mounted in the housing and located adjacent to the outlet.Type: ApplicationFiled: September 7, 2018Publication date: March 12, 2020Inventor: Grace LEE
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Patent number: 10569294Abstract: An improved hot melt glue gun with an automatic glue stick feeding structure includes a housing that is gun-shaped and that includes an inlet and an outlet. A glue stick feeding module is mounted in the housing and located adjacent to the inlet. The glue stick feeding module includes a motor connected to a casing. The casing includes a passage and a through-hole. The passage is located in the casing and intercommunicates with the inlet. The through-hole is aligned with the passage in a transverse direction. An activation module includes an activation rod reciprocatingly and movably extending through the through-hole. A micro switch is located adjacent to the activation module and is electrically connected to the motor. The micro switch is configured to be pressed by the activation rod to activate the motor. A hot melt module is mounted in the housing and located adjacent to the outlet.Type: GrantFiled: September 7, 2018Date of Patent: February 25, 2020Assignee: HOMEEASE INDUSTRIAL CORPORATION, LTDInventor: Grace Lee
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Publication number: 20200023030Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.Type: ApplicationFiled: September 30, 2019Publication date: January 23, 2020Inventors: Gong CHEN, Gang-Yi WU, Lei ZHANG, Jiu-Chao YIN, Hana YEH, Ning-Xin MA, Grace LEE
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Patent number: 10426814Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.Type: GrantFiled: August 10, 2017Date of Patent: October 1, 2019Assignee: The Penn State Research FoundationInventors: Gong Chen, Gang-Yi Wu, Lei Zhang, Jiu-Chao Yin, Hana Yeh, Ning-Xin Ma, Grace Lee
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Publication number: 20190276529Abstract: Methods of treating acute thyroid eye disease (TED) by administering a inhibitor, e.g., a VEGF-A inhibitor, e.g., an anti-VEGF antibody, optionally in combination with hyaluronidase, by periorbital or intraorbital injection. Also compositions comprising a VEGF inhibitor and hyaluronidase.Type: ApplicationFiled: June 8, 2017Publication date: September 12, 2019Applicants: Massachusetts Eye and Ear InfirmaryInventors: N. Grace LEE, Leo KIM, Patricia A. D`AMORE, James A. STEFATER
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Publication number: 20170354707Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.Type: ApplicationFiled: August 10, 2017Publication date: December 14, 2017Inventors: Gong CHEN, Gang-Yi WU, Lei ZHANG, Jiu-Chao YIN, Hana YEH, Ning-Xin MA, Grace LEE
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Patent number: D838480Type: GrantFiled: May 18, 2016Date of Patent: January 22, 2019Assignee: Samsung Electronics Co., Ltd.Inventors: Seounghyun Son, Howard Nuk, Dennis Miloseski, Rhys Bonahoom, Grace Lee, Jiyeon Lee
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Patent number: D877584Type: GrantFiled: August 29, 2018Date of Patent: March 10, 2020Assignee: HOMEEASE INDUSTRIAL CORPORATION, LTDInventor: Grace Lee