Abstract: A fault tolerant circuit arrangement includes: an input; an output; a first circuit element, a second circuit element, a third circuit element, and a fourth circuit element, provided in such a manner that the first and second circuit elements are connected in series between the input and the output to form a first series combination, and the third and fourth circuit elements are connected in series between the input and the output to form a second series combination, the first series combination being connected in parallel with the second series combination between the input and the output; and, a control element connected between an interconnection point of the first and second circuit elements and an interconnection point of the third and fourth circuit elements. The control element is switchable by a control signal between a conducting mode in which current flow is enabled between the interconnection points and a non-conducting mode in which current flow is prevented between the interconnection points.

Abstract: Compounds having formula I, or salts or prodrugs thereof: ##STR1## are selective agonists of the 5-HT.sub.1D.alpha. receptor and are useful in the treatment of migraine and associated conditions.

Abstract: A compound of formula (I), or a salt or prodrug thereof, is described, wherein G is attached at position 3 or 4 of the piperidine ring and represents halogen or C.sub.1-6 alkoxy; R1 represents C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, aryl(C.sub.1-6)alkyl or heteroaryl (C.sub.1-6)alkyl, any of which groups may be optionally substituted; processes for its preparation and its use in therapy, particularly in the treatment of migraine.

Abstract: A class of N-substituted piperazine, piperidine, and tetrahydropyridine derivatives, further subltitutedat the 4-position by an optionally substituted alkenyl, alkynyl, aryl-alkyl or heteroaryl-alkyl moiety, are selective agonists of 5-HT.sub.1 -like receptors, being potent agonists of the human 5-HT.sub.1D.alpha. receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT.sub.1D.alpha. receptor subtype relative to the 5-HT.sub.1D.beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT.sub.1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT.sub.1D receptor agonists.

Abstract: A class of 1-[3-(1H-indol-3-yl)propyl]-4-benzyl-1,2,5,6-tetrahydropyridine derivatives, substituted at the 5-position of the indole nucleus by a 1,2,4-triazol-4-yl moiety, and on the methylene linkage of the benzyl moiety by an alkyl, alkoxy, or alkoxy-alkoxy substituent, are selective agonists of 5-HT.sub.1 -like receptors, being potent agonists of the human 5-HT.sub.1D.alpha. receptor subtype while possessing at least a 10-fold selective affinity for the 5HT.sub.1D.alpha. receptor subtype relative to the 5-HT.sub.1D.beta. subtype. They are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT.sub.1D.alpha. receptors is indicated, and are expected to have fewer undesirable cardiovascular and other side effects.

Abstract: A fault tolerant circuit arrangement comprises a plurality of replicated non-redundant shift registers 30 connected in parallel and each having an enable/configuration input 31 and a plurality of outputs 36. Furthermore each register 30 includes a verify output 32 for outputting a verify signal indicating whether or not a fault condition is present within the register. The arrangement also includes a verification signal generator 33 for applying a fixed reference signal, a comparator 34 to which the verify signals from the outputs 32 are applied, and a control circuit 35. The test/control-logic of the comparator 34 and control circuit 35 is constructed using masking redundancy 20-24 in order to render the test/control logic tolerant to faults. The control circuit 35 serves to control testing of each of the registers 30 in turn by supplying an enable signal to the input 31 of each register 30 beginning with the first register. This causes the supply of a verify signal V.sub.

Abstract: A personal care composition in the form of an aqueous liquid comprises:i) a lipid composition comprising two components D and E, where D is a molecule having one long hydrocarbon chain and a hydrophillic head group and E is a material which comprises at least one of a compound selected from 3.beta.-sterol; squalane; squalane; saponins or sapogenins of the plant steroid or triterpenoid type; di and tri terpenes such as phytol, retinol and amyrin; and mixtures thereof, wherein D and E are respectively present at levels within the range 0.1 to 10 wt % and 0.2 a to 12 wt % based on the total composition;ii) a surface active agent selected from anionic, nonionic, cationic, zwitterionic, amphoteric surface active agents, soap and mixtures thereof; andiii) a deposition aid; andthe composition is substantially free of a molecule having at least two hydrocarbon chains and a polar head group which satisfies the relationship ##EQU1## where V is the volume of the hydrocarbon chainsI.sub.

Abstract: A class of substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of 5-HT.sub.1 -like receptors, being potent agonists of the human 5-HT.sub.1D.alpha. receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT.sub.1D.alpha. receptor subtype relative to the 5-HT.sub.1D.beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT.sub.1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT.sub.1D receptor agonists.

Abstract: A wheel cleaning cover, such as for a golf trolley wheel, is formed of a pair of hinged circular covers, each forming a semi-circular half and made of a light, robust material. When the golf trolley is not in use, a pair of such wheel covers can be closed around respective ones of the golf trolley's wheels. For each such wheel, the hinged semi-circular halves are securely fastened to one another to encase the associated wheel therewithin. The trolley wheels can remain on their axle(s) while the covers are securely closed around the wheels. When a cover is closed around its associated wheel and secured, it can be rotated and a brush installed in the cover functions as a cleaner/buffer, removing any mud, dirt, or grass on the enclosed wheel's surface. Debris from the wheel is contained within the cover until the cover is removed from the wheel, then any debris may be discarded.

Abstract: Compounds of formula (I), or a salt or prodrug thereof, wherein Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole, isoxazole, isothiazole, imidazole, pyrazole, oxadiazole, thiadiazole, triazole and tetrazole; E represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; Q represents a straight or branched alkylene chain containing from 1 to 6 carbon atoms, optionally substituted in any position by a hydroxy group; T represents nitrogen or CH; U represents nitrogen or C--R.sup.2 ; V represents oxygen, sulphur or N--R.sup.3 ; --F--G-- represents --CH2--N--, --CH2--CH-- or --CH.dbd.C--; R.sup.1 represents C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, aryl(C.sub.1-6)alkyl or heteroaryl(C.sub.1-6)alkyl, any of which groups may be optionally substituted; and R.sup.2 and R.sup.3 independently represent hydrogen or C.sub.

Abstract: Process for preparing a flavoring composition suitable as a butter flavor block by subjecting triglyceride fats, fatty acids or fatty acid derivatives to oxidizing conditions, comprising:(a) admixing an anti-oxidant to triglyceride fats, fatty acids or fatty acid derivatives at least to a concentration which is sufficient to increase the induction period of the fat by a factor of 1.5,(b) heating the mixture for 0.5 hours-1 week at 50.degree.-150.degree. C. under access of atmospheric oxygen and in the presence of water,under the condition that the triglyceride fats, fatty acids or fatty acid derivatives contain at least one poly-unsaturated fatty acid with an omega-3 non-conjugatable double bond system in an amount of >0.01 wt. %. Such fatty acids or derivatives of fatty acid are preferably obtained by partially hydrogenating a natural vegetable glyceride fat.

Abstract: A personal care composition in the form of an aqueous liquid comprises:i) a lipid composition comprising three components A, B and C,where A is a molecule having at least two hydrocarbon chains and a polar head group for which ##EQU1## B is a molecule having one long chain and a polar head group; and C comprises a compound capable of assisting the formation of lipid bilayers and stabilizing any lipid bilayers formed in the lipid composition; and the molar ratio of A:B:C is 1.0:1.5 to 6.0:1.1 to 8.0;ii) a surface active agent selected from anionic, nonionic, cationic, zwitterionic, amphoteric surface active agents, soap and mixtures thereof; andiii) a deposition aid.The composition may in the form of for example a shower gel or facial cleanser which is temporarily applied to the skin before being removed such as wiping or rinsing it from the skin.

Abstract: A class of substituted isoxazole and pyrazole derivatives of formula (I), or a salt thereof of or a prodrug thereof, wherein the broken circle represents two non-adjacent double bonds whereby the five-membered ring containing X and Y is aromatic; one of X and Y represents nitrogen, and the other of X and Y represents oxygen or N--R.sup.5 ; R.sup.1 represents hydrogen, C.sub.1-6 alkyl or trifluoromethyl; R.sup.2 and R.sup.3 independently represent hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, nitro, --OR.sup.a, --SR.sup.a, --SOR.sup.a, --SO.sub.2 R.sup.a, --SO.sub.2 NR.sup.a R.sup.b, --NR.sup.a R.sup.a, --NR.sup.a CO.sub.2 R.sup.b, --COR.sup.a, --CO.sub.2 R.sup.a or --CONR.sup.a R.sup.b, R.sup.4 represents hydrocarbon or a heterocyclic group; R.sup.5 represents hydrogen or C.sub.1-6 alkyl; and R.sup.a and R.sup.