Patents by Inventor Graham Cook

Graham Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SAMPLE ANALYSIS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20180033603
    Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
    Type: Application
    Filed: July 10, 2017
    Publication date: February 1, 2018
    Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
  • SYSTEMS AND METHODS FOR SCREENING A SAMPLE BASED ON MULTIPLE REACTION MONITORING MASS SPECTROMETRY
    Publication number: 20180024108
    Abstract: The invention generally relates to systems methods for screening a sample based on multiple reaction monitoring mass spectrometry. In certain embodiments, the invention provides methods for screening a sample that involve ionizing a sample. Mass spectrometry is then used in order to monitor specific transitions connecting one or more ion pairs within the sample in order to generate a multidimensional chemical profile of the sample. Then, the multidimensional chemical profile of the sample is compared to a database of reference multidimensional chemical profiles, thereby screening the sample. Each reference multidimensional chemical profile is produced from a training set of data.
    Type: Application
    Filed: July 14, 2017
    Publication date: January 25, 2018
    Inventors: Robert Graham Cooks, Christina Ramires Ferreira, Tiago Sobreira
  • ION GENERATION USING MODIFIED WETTED POROUS MATERIALS
    Publication number: 20180017535
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Application
    Filed: September 20, 2017
    Publication date: January 18, 2018
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • CONDUCTING REACTIONS IN LEIDENFROST-LEVITATED DROPLETS
    Publication number: 20170349547
    Abstract: The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.
    Type: Application
    Filed: June 5, 2017
    Publication date: December 7, 2017
    Inventors: Robert Graham Cooks, Christopher Pulliam, Ryan M. Bain
  • METHODS OF ANALYZING CRUDE OIL
    Publication number: 20170343526
    Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.
    Type: Application
    Filed: August 15, 2017
    Publication date: November 30, 2017
    Inventors: Robert Graham Cooks, Fred Paul Mark Jjunju, Anyin Li, Iman S. Roqan
  • SYSTEMS AND METHODS FOR PRODUCING METAL CLUSTERS; FUNCTIONALIZED SURFACES; AND DROPLETS INCLUDING SOLVATED METAL IONS
    Publication number: 20170335477
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Application
    Filed: August 1, 2017
    Publication date: November 23, 2017
    Inventors: Robert Graham Cooks, Michael Stanley Wleklinski, Thalappil Pradeep, Depanjan Sarkar
  • Mass spectrometry analysis of microorganisms in samples
    Publication number: 20170309462
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: April 10, 2017
    Publication date: October 26, 2017
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Ion generation using modified wetted porous materials
    Patent number: 9797872
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: October 24, 2017
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Ryan Espy
  • Zero voltage mass spectrometry probes and systems
    Patent number: 9786478
    Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: October 10, 2017
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Michael Stanley Wleklinski, Soumabha Bag, Yafeng Li
  • ION FOCUSING
    Publication number: 20170287690
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Application
    Filed: January 17, 2017
    Publication date: October 5, 2017
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • ENCLOSED DESORPTION ELECTROSPRAY IONIZATION PROBES AND METHOD OF USE THEREOF
    Publication number: 20170273605
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Application
    Filed: June 8, 2017
    Publication date: September 28, 2017
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-Hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Synchronization of ion generation with cycling of a discontinuous atmospheric interface
    Patent number: 9761426
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: September 12, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Jason Duncan, Guangming Huang, Guangtao Li, Xin Yan, Ewa Sokol, Xin Li
  • ANALYZING A METABOLITE LEVEL IN A SAMPLE
    Publication number: 20170248607
    Abstract: The invention generally relates to methods for analyzing a metabolite level in a sample. In certain embodiments, methods of the invention may involve obtaining a sample, analyzing the sample using a mass spectrometry technique to determine a level of at least one metabolite in the sample, and correlating the metabolite level with an originating source of the sample, thereby analyzing the sample.
    Type: Application
    Filed: January 17, 2017
    Publication date: August 31, 2017
    Inventors: Robert Graham Cooks, Kevin Scott Kerian, Alan Keith Jarmusch, Ahmed Mohamed Hamid, Livia Schiavinato Eberlin
  • Methods of analyzing crude oil
    Patent number: 9733228
    Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: August 15, 2017
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Fred Paul Mark Jjunju, Anyin Li, Iman S. Rogan
  • SYSTEMS AND METHODS FOR EJECTION OF IONS FROM AN ION TRAP
    Publication number: 20170221695
    Abstract: The invention generally relates to systems and methods for ejection of ions from an ion trap. In certain embodiments, systems and methods of the invention sum two different frequency signals into a single summed signal that is applied to an ion trap. In other embodiments, an amplitude of a single frequency signal is modulated as the single frequency signal is being applied to the ion trap. In other embodiments, a first alternating current (AC) signal is applied to an ion trap that varies as a function of time, while a constant radio frequency (RF) signal is applied to the ion trap.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 3, 2017
    Inventors: Robert Graham Cooks, Dalton Snyder
  • Systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions
    Patent number: 9719181
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: August 1, 2017
    Assignees: PURDUE RESEARCH FOUNDATION, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Robert Graham Cooks, Anyin Li, Qingjie Luo
  • Sample analysis systems and methods of use thereof
    Patent number: 9704700
    Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: July 11, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
  • Enclosed desorption electrospray ionization probes and method of use thereof
    Patent number: 9700251
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: July 11, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-Hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • ION GENERATION USING MODIFIED WETTED POROUS MATERIALS
    Publication number: 20170168032
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Application
    Filed: November 22, 2016
    Publication date: June 15, 2017
    Inventors: Robert Graham Cooks, Zheng Ouyang, He Wang
  • SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS
    Publication number: 20170154761
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Application
    Filed: November 1, 2016
    Publication date: June 1, 2017
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar