Patents by Inventor Graham Cook

Graham Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170135613
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Application
    Filed: January 6, 2017
    Publication date: May 18, 2017
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-Hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Publication number: 20170130352
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Application
    Filed: January 23, 2017
    Publication date: May 11, 2017
    Inventors: Robert Graham Cooks, Anyin Li, Qingjie Luo
  • Publication number: 20170103879
    Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
    Type: Application
    Filed: June 16, 2015
    Publication date: April 13, 2017
    Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
  • Patent number: 9620344
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: April 11, 2017
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Publication number: 20170082604
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
    Type: Application
    Filed: November 21, 2016
    Publication date: March 23, 2017
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Publication number: 20170084438
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 23, 2017
    Inventors: Robert Graham Cooks, Jason Duncan, Guangming Huang, Guangtao Li, Xin Yan, Ewa Sokol, Xin Li
  • Patent number: 9551079
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: January 24, 2017
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Anyin Li, Qingjie Luo
  • Patent number: 9548192
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: January 17, 2017
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Patent number: 9546979
    Abstract: The invention generally relates to methods for analyzing a metabolite level in a sample. In certain embodiments, methods of the invention may involve obtaining a sample, analyzing the sample using a mass spectrometry technique to determine a level of at least one metabolite in the sample, and correlating the metabolite level with an originating source of the sample, thereby analyzing the sample.
    Type: Grant
    Filed: June 4, 2013
    Date of Patent: January 17, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Kevin Scott Kerian, Alan Keith Jarmusch, Ahmed Mohamed Hamid, Livia Schiavinato Eberlin
  • Patent number: 9538945
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: January 10, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-Hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Patent number: 9500623
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: November 22, 2016
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Jason Duncan, Guangming Huang, Guangtao Li, Xin Yan, Ewa Sokol, Xin Li
  • Patent number: 9500630
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: November 22, 2016
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, He Wang
  • Patent number: 9500572
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof. In certain embodiments, the invention provides a fluid dispenser that includes a fluid chamber. A portion of an inner wall of the chamber includes an internal standard. The chamber is configured such that fluid introduced to the chamber must interact with the portion of the chamber wall that includes the internal standard prior to flowing through an outlet of the chamber. The dispenser additionally includes a member coupled to the chamber such that it can control movement of fluid within the chamber.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: November 22, 2016
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Patent number: 9484195
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: November 1, 2016
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Publication number: 20160314956
    Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.
    Type: Application
    Filed: December 22, 2014
    Publication date: October 27, 2016
    Inventors: Robert Graham Cooks, Depanjan Sarkar, Thalappil Pradeep, Rahul Narayanan
  • Patent number: 9477770
    Abstract: Source data stored on a source device may be shared with other devices. Sharing the source data may include facilitating communication associated with the source data, based on a communication protocol, between a first device and another device. Receiving a first token associated with the source data may be facilitated. The first token may be encoded to generate a visual tag. An image of the visual tag may be provided to enable a second device to capture the image, retrieve the first token after decoding the visual tag, and use the first token to access the source data utilizing a communication protocol.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: October 25, 2016
    Assignee: Wyse Technology L.L.C.
    Inventors: Stephen Scott Doss, Richard Graham Cook, Daniel Ernesto Barreto
  • Publication number: 20160254131
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: April 21, 2014
    Publication date: September 1, 2016
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Publication number: 20160163524
    Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
    Type: Application
    Filed: December 3, 2015
    Publication date: June 9, 2016
    Inventors: Robert Graham Cooks, Michael Stanley Wleklinski, Soumabha Bag, Yafeng Li
  • Publication number: 20160155622
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Application
    Filed: November 9, 2015
    Publication date: June 2, 2016
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Publication number: 20160131621
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Application
    Filed: January 4, 2016
    Publication date: May 12, 2016
    Inventors: Robert Graham Cooks, Zheng Ouyang, He Wang