Patents by Inventor Graham Johnson
Graham Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11117884Abstract: Provided herein are compounds and methods for treating a disorder associated with aberrant A? peptide levels, including Alzheimer's disease.Type: GrantFiled: October 25, 2019Date of Patent: September 14, 2021Assignees: The General Hospital Corporation, The Regents of the University of CaliforniaInventors: Steven L. Wagner, William C. Mobley, Rudolph E. Tanzi, Graham Johnson, Ronald Buckle, Nicholas Mayhew, Robert Jason Herr, Kevin D. Rynearson
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Publication number: 20210214360Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: November 16, 2020Publication date: July 15, 2021Applicant: The Trustees of Columbia University in the City of New YorkInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Rando Allikmets, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Publication number: 20210188834Abstract: The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.Type: ApplicationFiled: February 18, 2021Publication date: June 24, 2021Applicant: ARIAGEN, INC.Inventors: Graham Johnson, Peter Colabuono, Paul Gerard Pearson, David Douglas Manning
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Publication number: 20210179604Abstract: The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.Type: ApplicationFiled: February 18, 2021Publication date: June 17, 2021Applicant: ARIAGEN, INC.Inventors: Peter Colabuono, Graham Johnson, David Douglas Manning, Mark Allan Wolf
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Patent number: 11028098Abstract: The present invention provide a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterocycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 3, 2018Date of Patent: June 8, 2021Assignee: The Trustees of Columbia University in the City of New YorkInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Nicoleta Dobri, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Patent number: 10913746Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 24, 2019Date of Patent: February 9, 2021Assignee: The Trustees of Columbia University in the City of New YorkInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Rando Allikmets, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Publication number: 20200354353Abstract: The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.Type: ApplicationFiled: November 19, 2018Publication date: November 12, 2020Applicant: ARIAGEN, INC.Inventors: Peter Colabuono, Graham Johnson, David Douglas Manning, Mark Allan Wolf
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Publication number: 20200345705Abstract: Described herein is (4R,7,S)-2-(3-(4-chlorophenyl)ureido)-9-methyl-5,6,7,8-tetrahydro-4H-4,7-epiminocyclohepta[b]thiophene-3-carboxamide mesylate, including crystalline forms and solvates thereof.Type: ApplicationFiled: August 31, 2018Publication date: November 5, 2020Applicant: University of WashingtonInventors: Graham Johnson, Edwin Aret, Alexei Tchesnokov
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Patent number: 10787453Abstract: The present invention provides compounds comprising variously substituted octahydropyrrolopyrroles, their synthesis, methods of making, methods of using, compositions and formulations thereof.Type: GrantFiled: April 11, 2018Date of Patent: September 29, 2020Assignee: The Trustees of Columbia University in the City of New YorkInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Nicoleta Dobri, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Publication number: 20200283441Abstract: Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.Type: ApplicationFiled: May 18, 2020Publication date: September 10, 2020Inventors: Susan A. Slaugenhaupt, Graham Johnson, William D. Paquette, Wei Zhang, Juan Marugan
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Patent number: 10690564Abstract: There is provided a leak detection system for detecting breaches in sealed food containers. The leak detection system comprises air-sample testing equipment configured to test the composition of an air sample provided to the air-sample testing equipment. At least one pressing member is provided configured to, in use, apply pressure to the sealed food container located in an air-sampling region. At least one air-sampling port is located in the air-sampling region. An air sample conduit is provided extending between the at least one air-sampling port and the air-sample testing equipment. In use, the at least one air-sampling port takes an air sample from the air-sampling region at least during or after the at least one pressing member applies pressure to the sealed food container in the air-sampling region and communicates said air sample through the air sample conduit to the air-sample testing equipment.Type: GrantFiled: May 5, 2017Date of Patent: June 23, 2020Assignee: ISHIDA EUROPE LIMITEDInventors: David Hann, Graham Neale, Lee Graham Johnson, Lee Vine
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Patent number: 10676475Abstract: Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.Type: GrantFiled: January 15, 2016Date of Patent: June 9, 2020Assignees: The General Hospital Corporation, The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Susan A. Slaugenhaupt, Graham Johnson, William D. Paquette, Wei Zhang, Juan Marugan
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Patent number: 10570148Abstract: The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 3, 2018Date of Patent: February 25, 2020Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Nicoleta Dobri, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Publication number: 20200055840Abstract: Provided herein are compounds and methods for treating a disorder associated with aberrant A? peptide levels, including Alzheimer's disease.Type: ApplicationFiled: October 25, 2019Publication date: February 20, 2020Inventors: Steven L. Wagner, William C. Mobley, Rudolph E. Tanzi, Graham Johnson, Ronald Buckle, Nicholas Mayhew, Robert Jason Herr, Kevin D. Rynearson
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Publication number: 20190382409Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 24, 2019Publication date: December 19, 2019Applicant: The Trustees of Columbia University in the City of New YorkInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Rando Allikmets, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Patent number: 10472346Abstract: Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant A? peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L? is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene.Type: GrantFiled: October 30, 2015Date of Patent: November 12, 2019Assignees: The General Hospital Corporation, The Regents of the University of CaliforniaInventors: Steven L. Wagner, William C. Mobley, Rudolph E. Tanzi, Graham Johnson, Ronald Buckle, Nicholas Mayhew, Robert Jason Herr, Kevin D. Rynearson
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Patent number: 10421720Abstract: The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina.Type: GrantFiled: March 26, 2018Date of Patent: September 24, 2019Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Nicoleta Dobri, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Patent number: 10407433Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 8, 2018Date of Patent: September 10, 2019Assignee: The Trustees of Columbia University In The City of New YorkInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Rando Allikmets, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Patent number: 10399994Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.Type: GrantFiled: February 5, 2016Date of Patent: September 3, 2019Assignees: University of Washington, Oricula Therapeutics LLC, Fred Hutchinson Cancer Research CenterInventors: Julian Simon, Graham Johnson, Edwin W. Rubel, David W. Raible, Mario D. Gonzalez, Peter C. Meltzer, Weishi Miao
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Publication number: 20190178745Abstract: There is provided a leak detection system for detecting breaches in sealed food containers. The leak detection system comprises air-sample testing equipment configured to test the composition of an air sample provided to the air-sample testing equipment. At least one pressing member is provided configured to, in use, apply pressure to the sealed food container located in an air-sampling region. At least one air-sampling port is located in the air-sampling region. An air sample conduit is provided extending between the at least one air-sampling port and the air-sample testing equipment. In use, the at least one air-sampling port takes an air sample from the air-sampling region at least during or after the at least one pressing member applies pressure to the sealed food container in the air-sampling region and communicates said air sample through the air sample conduit to the air-sample testing equipment.Type: ApplicationFiled: May 5, 2017Publication date: June 13, 2019Applicant: ISHIDA EUROPE LIMITEDInventors: David HANN, Graham NEALE, Lee Graham JOHNSON, Lee VINE