Abstract: The present invention provides a series of non-peptidergic antagonists of NPY comprising piperidine derivatives of 4-phenyl-1,4-dihydropyrimidinones of the Formula I ##STR1## wherein R, R.sup.1 and R.sup.2 are defined herein. As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Abstract: Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.

Abstract: Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.

Abstract: The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.

Abstract: Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.

Abstract: Corneal onlays for use in surgical implantation into or onto the cornea of a mammal are described. The corneal onlays according to the invention have an optical axis region with optical characteristics which provide visual acuity therethrough and are comprised of a non-biodegradable non-hydrogel ocularly biocompatible material, characterized in that the onlay has a porosity sufficient to allow passage therethrough of tissue fluid components having a molecular fluid weight greater than 10,000 daltons so as to provide for a flux of tissue fluid between cells anterior of the implanted onlay and cells posterior thereof. The porosity of the optical axis region is such that it allows the flux of tissue fluid components whilst excluding ingrowth of ocular tissue. The onlay is further characterized by being adapted for epithelial recolonization.

Abstract: A magnetostrictive active member configured to withstanding significant bending moments and having a prestress mechanism that is adjustable for maintaining optimal performance of an integral magnetostrictive element. The magnetostrictive active member includes a magnetostrictive actuator and parallel flexures incorporated in a housing to create a load path for bending moments to be carried by the housing, through the parallel flexures, as opposed to being carried by the magnetostrictive actuator. A plurality of ball-joints are integrated with the flexures and magnetostrictive actuator, receiving compressire forces and ensuring that no moments are applied to the magnetostrictive actuator. A prestress or preload mechanism is incorporated which provides a compressire preload to the magnetostrictive actuator internal to the housing. The preload mechanism includes an adjustable nut than is externally accessible to adjust the preload and facilitate optimal performance of the magnetostrictive actuator.

Abstract: A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Abstract: A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Abstract: The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.

Abstract: Disclosed herein is a process for preparing a compound of structure (I): ##STR1## which comprises cyclization of a compound of structure (II) ##STR2##

Abstract: This invention comprises a process for preparing benzopyran derivatives represented by formula (I) ##STR1## in which, R.sup.1 is C.sub.1-20 alkyl, C.sub.2-20 alkenyl, C.sub.2-20 alkynyl, or a group of structure (i), (ii) or (iii).

Abstract: Certain N-acyl-cycloalkylamine derivatives are useful as melatonergic agents.

Abstract: A process for preparing substituted benzopyran derivatives which comprises a final step cyclisation of the corresponding open-chain intermediates.

Abstract: A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of nitrogen heterocyclic derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Abstract: A process for producing a polymeric surface coating which faciliates attachment of cells on a polymeric substrate. The coating is deposited by plasma deposition of an amide monomer vapour. The coated product is suitable for use in tissue culture trays and biomedical implants.

Abstract: A transcoder is described for performing transcoding operations, that is to say coding and decoding operations on voice data arranged over a plurality of voice data channels. It comprises a first interface (10) for inputting and outputting coded voice data, a second interface (11) for inputting and outputting decoded voice data; at least one transcoder processor (101) for performing transcoding operations on voice data arranged over at least two voice data channels; and an input/output processor (100) coupled to the first and second interfaces and the at least one transcoder processor for controlling the flow of data between the first and second interfaces and the at least one transcoder processor. The input/output processors controls the at least one transcoder processor to perform transcoding operations on a selected channel at a given time. The invention is particularly applicable to transcoding between CEPT standard voice data and GSM standard voice data.

Abstract: The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.

Abstract: The present invention relates to novel 3-substituted-2-carboxyindoles; including as 3-substituents amides of hydroxamic acids and derivatives thereof or urea and carbonyl, carboxyl or phosphonic acids or ester amides, or 2-acylsulfonamides thereof; and including also as 3-substituents unsaturated acids and their further ester and amide derivatives. These 2-carboxyindoles are useful as pharmaceutical agents, therefore, the present invention is also pharmaceutical compositions and pharmaceutical methods of treatment therefor. The compounds of the present invention are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders.

Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.