Patents by Inventor Graham P. Lidgard

Graham P. Lidgard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF LUNG NEOPLASIA BY AMPLIFICATION OF RNA SEQUENCES
    Publication number: 20230121671
    Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
    Type: Application
    Filed: September 15, 2022
    Publication date: April 20, 2023
    Inventors: Hatim Allawi, Graham P. Lidgard, Chateen Krueger, Michael W. Kaiser, Tamara J. Sander
  • CHARACTERIZING METHYLATED DNA, RNA, AND PROTEINS IN SUBJECTS SUSPECTED OF HAVING LUNG NEOPLASIA
    Publication number: 20220403471
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as lung cancer.
    Type: Application
    Filed: August 27, 2020
    Publication date: December 22, 2022
    Inventors: Scott Morris, David Mallery, Hatim T. Allawi, Graham P. Lidgard, Maria Giakoumopoulos, Michael W. Kaiser, David A. Ahlquist, William R. Taylor, Douglas W. Mahoney
  • METHOD FOR STABILIZING HEMOGLOBIN AND REAGENTS FOR PERFORMING THE SAME
    Publication number: 20220373564
    Abstract: A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin, or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.
    Type: Application
    Filed: June 6, 2022
    Publication date: November 24, 2022
    Inventors: Keith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
  • Real time cleavage assay
    Patent number: 11499179
    Abstract: A cleavage-based real-time PCR assay method is provided. In general terms, the assay method includes subjecting a reaction mixture comprising a) PCR reagents for amplifying a nucleic acid target, and b) flap cleavage reagents for performing a flap cleavage assay on the amplified nucleic acid target to two sets of thermocycling conditions. No additional reagents are added to the reaction between said first and second sets of cycles and, in each cycle of the second set of cycles, cleavage of a flap probe is measured.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: November 15, 2022
    Assignee: Exact Sciences Development Company, LLC
    Inventors: Rebecca Oldham-Haltom, Hongzhi Zou, Graham P. Lidgard, Michael J. Domanico, Hatim Allawi
  • DETECTING ESOPHAGEAL DISORDERS
    Publication number: 20220349009
    Abstract: Provided herein is technology for screening for esophageal disorders, including but not limited to, Barrett's esophagus (BE). In particular, provided herein are methods, compositions, and related uses for detecting the presence or absence of esophageal disorders from a biological sample.
    Type: Application
    Filed: April 22, 2022
    Publication date: November 3, 2022
    Inventors: William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, John B. Kisiel, David A. Ahlquist, Hatim T. Allawi, Graham P. Lidgard, Maria Giakoumopoulos
  • METHYLATED CONTROL DNA
    Publication number: 20220340959
    Abstract: Provided herein is technology relating compositions and methods for analysis of methylated DNA from a subject. The technology also relates to use of endogenous methylated DNAs as internal controls for marker gene methylation assays.
    Type: Application
    Filed: May 10, 2022
    Publication date: October 27, 2022
    Inventors: Hatim T. Allawi, Graham P. Lidgard
  • Detection of lung neoplasia by amplification of RNA sequences
    Patent number: 11479823
    Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: October 25, 2022
    Assignee: Exact Sciences Corporation
    Inventors: Hatim Allawi, Graham P. Lidgard, Chateen Krueger, Michael W. Kaiser, Tamara J. Sander
  • Multiplexed Kras Mutation Detection Assay
    Publication number: 20220333210
    Abstract: Provided herein is reagent mixture comprising multiplexed amplification reagents and flap assay reagents for detecting, in a single reaction, mutant copies of the KRAS gene that contain any of the 34A, 34C, 34T, 35A, 35C, 35T or 38A point mutations. Methods that employ the reagent mix and kits for performing the same are also provided.
    Type: Application
    Filed: May 9, 2022
    Publication date: October 20, 2022
    Inventors: Rebecca Oldham-Haltom, Hatim Allawi, Hongzhi Zou, Michael J. Domanico, Graham P. Lidgard
  • MULTIPLEX AMPLIFICATION DETECTION ASSAY
    Publication number: 20220267831
    Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.
    Type: Application
    Filed: March 11, 2022
    Publication date: August 25, 2022
    Inventors: Graham P. Lidgard, Hatim Allawi
  • Method for stabilizing hemoglobin and reagents for performing the same
    Patent number: 11385243
    Abstract: A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin, or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: July 12, 2022
    Assignee: EXACT SCIENCES CORPORATION
    Inventors: Keith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
  • Detecting colorectal neoplasm
    Patent number: 11365451
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: June 21, 2022
    Assignees: Mayo Foundation for Medical Education and Research, Exact Sciences Corporation
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • Multiplexed KRAS mutation detection assay
    Patent number: 11352674
    Abstract: Provided herein is reagent mixture comprising multiplexed amplification reagents and flap assay reagents for detecting, in a single reaction, mutant copies of the KRAS gene that contain any of the 34A, 34C, 34T, 35A, 35C, 35T or 38A point mutations. Methods that employ the reagent mix and kits for performing the same are also provided.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: June 7, 2022
    Assignee: Exact Sciences Development Company, LLC
    Inventors: Rebecca Oldham-Haltom, Hatim Allawi, Hongzhi Zou, Michael J. Domanico, Graham P. Lidgard
  • Methylated control DNA
    Patent number: 11345949
    Abstract: Provided herein is technology relating compositions and methods for analysis of methylated DNA from a subject. The technology also relates to use of endogenous methylated DNAs as internal controls for marker gene methylation assays.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: May 31, 2022
    Assignee: Exact Sciences Corporation
    Inventors: Hatim T. Allawi, Graham P. Lidgard
  • NUCLEIC ACID CONTROL MOLECULES FROM NON-HUMAN ORGANISMS
    Publication number: 20220136035
    Abstract: The present invention provides synthetic DNA strands that find use as process controls in DNA processing and nucleic acid testing methods. In particular, provided herein are synthetic methylated DNA strands of known composition for use as control molecules in DNA testing, e.g., of mutations and/or methylation of DNA isolated from non-fish samples, such as human samples.
    Type: Application
    Filed: November 18, 2021
    Publication date: May 5, 2022
    Inventors: Hatim T. Allawi, Graham P. Lidgard, Brian Aizenstein, Melissa M. Gray
  • CHARACTERIZING METHYLATED DNA, RNA, AND PROTEINS IN THE DETECTION OF LUNG NEOPLASIA
    Publication number: 20220136058
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as lung cancer.
    Type: Application
    Filed: November 26, 2019
    Publication date: May 5, 2022
    Inventors: Hatim Allawi, Graham P. Lidgard, Maria Giakoumopoulos, David A. Ahlquist, William R. Taylor, Douglas Mahoney
  • Multiplex Amplification Detection Assay II
    Publication number: 20220119862
    Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.
    Type: Application
    Filed: November 5, 2021
    Publication date: April 21, 2022
    Inventors: Hatim T. Allawi, William G. Weisburg, Graham P. Lidgard, Michael W. Kaiser, Abram M. Vaccaro, Gracie Shea
  • Multiplex amplification detection assay
    Patent number: 11299766
    Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: April 12, 2022
    Assignee: Exact Sciences Corporation
    Inventors: Graham P. Lidgard, Hatim Allawi
  • SAMPLING DEVICE AND ANALYSIS OF METHYLATED DNA
    Publication number: 20220071605
    Abstract: The invention relates to cell sampling devices. In particular, the present invention relates to ingestible cell sampling devices for sampling cells in a subject, and methods of use for detecting abnormalities in a subject using the same. Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer.
    Type: Application
    Filed: April 16, 2021
    Publication date: March 10, 2022
    Inventors: Robert F. Eisele, Michael E. Williams, Prasad G. Iyer, Paul Marrione, Hatim T. Allawi, Graham P. Lidgard, Maria Giakoumopoulos, William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, John B. Kisiel, David A. Ahlquist
  • DETECTION OF COLON NEOPLASIA BY ANALYSIS OF METHYLATED DNA
    Publication number: 20220056526
    Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.
    Type: Application
    Filed: August 23, 2021
    Publication date: February 24, 2022
    Inventors: Hatim T. Allawi, Michael W. Kaiser, Graham P. Lidgard, William R. Taylor, Tamara J. Sander, Abram M. Vaccaro
  • COMPOSITIONS AND METHODS FOR PERFORMING METHYLATION DETECTION ASSAYS
    Publication number: 20220042111
    Abstract: Provided herein is technology relating to performing methylation assays. In particular, the technology relates to internal controls for methylation assays.
    Type: Application
    Filed: August 23, 2021
    Publication date: February 10, 2022
    Inventors: David Alan Ahlquist, William Russell Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi, Abram Michael Vaccaro