Patents by Inventor Graham P. Lidgard

Graham P. Lidgard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detecting esophageal disorders
    Patent number: 10435755
    Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 8, 2019
    Assignees: Exact Sciences Development Company, LLC, Mayo Foundation for Medical Education and Research
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Douglas W. Mahoney, Tracy C. Yab, Graham P. Lidgard, Hatim T. Allawi
  • METHOD FOR STABILIZING HEMOGLOBIN AND REAGENTS FOR PERFORMING THE SAME
    Publication number: 20190302129
    Abstract: A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin, or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.
    Type: Application
    Filed: March 15, 2019
    Publication date: October 3, 2019
    Inventors: Keith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
  • Detection of lung neoplasia by analysis of methylated DNA
    Patent number: 10385406
    Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: August 20, 2019
    Assignees: EXACT SCIENCES DEVELOPMENT COMPANY, LLC, Mayo Foundation for Medical Education and Research
    Inventors: Hatim Allawi, Graham P. Lidgard, Maria Giakoumopoulos, David A. Ahlquist, William R. Taylor, Douglas Mahoney
  • DETECTING COLORECTAL NEOPLASM
    Publication number: 20190249263
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 15, 2019
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • METHYLATED CONTROL DNA
    Publication number: 20190218601
    Abstract: Provided herein is technology relating compositions and methods for analysis of methylated DNA from a subject. The technology also relates to use of endogenous methylated DNAs as internal controls for marker gene methylation assays.
    Type: Application
    Filed: July 19, 2017
    Publication date: July 18, 2019
    Inventors: Hatim T. Allawi, Graham P. Lidgard
  • MULTIPLEX AMPLIFICATION DETECTION ASSAY II
    Publication number: 20190177769
    Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.
    Type: Application
    Filed: December 13, 2017
    Publication date: June 13, 2019
    Inventors: Hatim T. Allawi, William G. Weisburg, Graham P. Lidgard, Michael W. Kaiser, Abram M. Vaccaro, Gracie Shea
  • DETECTING BREAST CANCER
    Publication number: 20190161805
    Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.
    Type: Application
    Filed: November 28, 2018
    Publication date: May 30, 2019
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab, John B. Kisiel, Hatim T. Allawi, Graham P. Lidgard, Michael W. Kaiser
  • DETECTING BREAST CANCER
    Publication number: 20190161806
    Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.
    Type: Application
    Filed: November 28, 2018
    Publication date: May 30, 2019
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab, John B. Kisiel, Hatim T. Allawi, Graham P. Lidgard, Michael W. Kaiser
  • Detecting colorectal neoplasm
    Patent number: 10301680
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: May 28, 2019
    Assignees: Mayo Foundation for Medical Education and Research, Exact Sciences Development Company, LLC
    Inventors: David Alan Ahlquist, William Russell Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • SYNTHETIC NUCLEIC ACID CONTROL MOLECULES
    Publication number: 20190144948
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Application
    Filed: October 23, 2018
    Publication date: May 16, 2019
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • Multiple-control calibrators for DNA quantitation
    Patent number: 10253358
    Abstract: The present invention provides DNA plasmids that find use as calibrators or reference standards for calculating DNA quantities in a sample. In particular, provided herein are DNA plasmids that contain multiple control fragments, and methods of their use in DNA quantitation.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: April 9, 2019
    Assignee: EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: Michael Domanico, Ilse A. Tyler, Brian Aizenstein, Hatim Allawi, Graham P. Lidgard
  • ISOLATION OF NUCLEIC ACIDS
    Publication number: 20190100788
    Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 4, 2019
    Inventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
  • Multiplexed Kras Mutation Detection Assay
    Publication number: 20190055609
    Abstract: Provided herein is reagent mixture comprising multiplexed amplification reagents and flap assay reagents for detecting, in a single reaction, mutant copies of the KRAS gene that contain any of the 34A, 34C, 34T, 35A, 35C, 35T or 38A point mutations. Methods that employ the reagent mix and kits for performing the same are also provided.
    Type: Application
    Filed: August 27, 2018
    Publication date: February 21, 2019
    Inventors: Rebecca Oldham-Haltom, Hatim Allawi, Hongzhi Zou, Michael J. Domanico, Graham P. Lidgard
  • MODIFICATION OF DNA ON MAGNETIC BEADS
    Publication number: 20190048399
    Abstract: Provided herein is technology related to the chemical modification and purification of DNA. Specifically, the technology provides methods for performing a bisulfite conversion reaction on small amounts of single-stranded, fragmented DNA and performing the subsequent desulfonation and purification steps on magnetic beads.
    Type: Application
    Filed: October 18, 2018
    Publication date: February 14, 2019
    Inventors: Michael J. Domanico, Hatim Allawi, Graham P. Lidgard, Brian Aizenstein, Oliver Hunt, Tobias Charles Zutz
  • Isolation of nucleic acids
    Patent number: 10196676
    Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: February 5, 2019
    Assignee: Exact Sciences Corporation
    Inventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
  • MUTATION DETECTION ASSAY
    Publication number: 20180346993
    Abstract: A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to said wild type copies of the genomic locus, to produce an amplified sample, where: i. the amplifying is done using a first primer and a second primer; and ii. the first primer comprises a 3? terminal nucleotide that base pairs with the point mutation and also comprises a nucleotide sequence that is fully complementary to a sequence in the locus with the exception of a single base mismatch within 6 bases of the 3? terminal nucleotide; and b) detecting the presence of said product in said amplified sample using a flap assay that employs an invasive oligonucleotide. A kit for performing the method is also provided.
    Type: Application
    Filed: May 23, 2018
    Publication date: December 6, 2018
    Inventors: Hongzhi Zou, Graham P. Lidgard, Michael J. Domanico, Hatim Allawi
  • Modification of DNA on magnetic beads
    Patent number: 10144953
    Abstract: Provided herein is technology related to the chemical modification and purification of DNA. Specifically, the technology provides methods for performing a bisulfite conversion reaction on small amounts of single-stranded, fragmented DNA and performing the subsequent desulfonation and purification steps on magnetic beads.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: December 4, 2018
    Assignee: Exact Sciences Development Company, LLC
    Inventors: Michael J. Domanico, Hatim Allawi, Graham P. Lidgard, Brian Aizenstein, Oliver Hunt, Tobias Charles Zutz
  • Synthetic nucleic acid control molecules
    Patent number: 10138524
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: November 27, 2018
    Assignee: EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • ISOLATION OF NUCLEIC ACIDS
    Publication number: 20180327814
    Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.
    Type: Application
    Filed: July 26, 2018
    Publication date: November 15, 2018
    Inventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
  • COMPOSITIONS AND METHODS FOR PERFORMING METHYLATION DETECTION ASSAYS
    Publication number: 20180291469
    Abstract: Provided herein is technology relating to performing methylation assays. In particular, the technology relates to internal controls for methylation assays.
    Type: Application
    Filed: June 20, 2018
    Publication date: October 11, 2018
    Inventors: David Alan Ahlquist, William Russell Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi, Abram Michael Vaccaro