Patents by Inventor Graham P. Lidgard

Graham P. Lidgard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multiplexed KRAS mutation detection assay
    Patent number: 10093987
    Abstract: Provided herein is reagent mixture comprising multiplexed amplification reagents and flap assay reagents for detecting, in a single reaction, mutant copies of the KRAS gene that contain any of the 34A, 34C, 34T, 35A, 35C, 35T or 38A point mutations. Methods that employ the reagent mix and kits for performing the same are also provided.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: October 9, 2018
    Assignee: EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: Rebecca Oldham-Haltom, Hatim Allawi, Hongzhi Zou, Michael J. Domanico, Graham P. Lidgard
  • DETECTING NEOPLASM
    Publication number: 20180258498
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
    Type: Application
    Filed: May 14, 2018
    Publication date: September 13, 2018
    Inventors: David A. Ahlquist, John B. Kisiel, William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • DETECTION OF COLON NEOPLASIA BY ANALYSIS OF METHYLATED DNA
    Publication number: 20180245157
    Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.
    Type: Application
    Filed: January 26, 2018
    Publication date: August 30, 2018
    Inventors: Hatim T. Allawi, Michael W. Kaiser, Graham P. Lidgard, William R. Taylor, Tamara J. Sander, Abram M. Vaccaro
  • Isolation of nucleic acids
    Patent number: 10047390
    Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: August 14, 2018
    Assignee: Exact Sciences Corporation
    Inventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
  • Compositions and methods for performing methylation detection assays
    Patent number: 10011878
    Abstract: Provided herein is technology relating to performing methylation assays. In particular, the technology relates to internal controls for methylation assays.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: July 3, 2018
    Assignee: Exact Sciences Development Company
    Inventors: David Alan Ahlquist, William Russell Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi, Abram Michael Vaccaro
  • Mutation detection assay
    Patent number: 10000817
    Abstract: A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to said wild type copies of the genomic locus, to produce an amplified sample, where: i. the amplifying is done using a first primer and a second primer; and ii. the first primer comprises a 3? terminal nucleotide that base pairs with the point mutation and also comprises a nucleotide sequence that is fully complementary to a sequence in the locus with the exception of a single base mismatch within 6 bases of the 3? terminal nucleotide; and b) detecting the presence of said product in said amplified sample using a flap assay that employs an invasive oligonucleotide. A kit for performing the method is also provided.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: June 19, 2018
    Assignee: EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: Hongzhi Zou, Graham P. Lidgard, Michael J. Domanico, Hatim Allawi
  • Detecting neoplasm
    Patent number: 9994911
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer. Accordingly, provided herein is technology for pancreatic cancer screening markers and other gastrointestinal cancer screening markers that provide a high signal to-noise ratio and a low background level when detected from samples taken from a subject (e.g., stool sample). As described herein, the technology provides a number of methylated DNA markers and subsets thereof (e.g., sets of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more markers) with high discrimination for G1 neoplasms overall and/or at individual tumor sites.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 12, 2018
    Assignees: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: David A. Ahlquist, John B. Kisiel, William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • ISOLATION OF NUCLEIC ACIDS
    Publication number: 20180135105
    Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.
    Type: Application
    Filed: November 9, 2017
    Publication date: May 17, 2018
    Inventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
  • DETECTING HEPATOCELLULAR CARCINOMA
    Publication number: 20180066320
    Abstract: Provided herein is technology for hepatocellular carcinoma screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of hepatocellular carcinoma.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 8, 2018
    Inventors: William R. Taylor, David A. Ahlquist, Douglas W. Mahoney, John B. Kisiel, Tracy C. Yab, Hatim T. Allawi, Maria Giakoumopoulos, Graham P. Lidgard
  • Multiplexed Kras Mutation Detection Assay
    Publication number: 20180066319
    Abstract: Provided herein is reagent mixture comprising multiplexed amplification reagents and flap assay reagents for detecting, in a single reaction, mutant copies of the KRAS gene that contain any of the 34A, 34C, 34T, 35A, 35C, 35T or 38A point mutations. Methods that employ the reagent mix and kits for performing the same are also provided.
    Type: Application
    Filed: August 24, 2017
    Publication date: March 8, 2018
    Inventors: Rebecca Oldham-Haltom, Hatim Allawi, Hongzhi Zou, Michael J. Domanico, Graham P. Lidgard
  • DETECTING ESOPHAGEAL DISORDERS
    Publication number: 20180037958
    Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).
    Type: Application
    Filed: March 23, 2016
    Publication date: February 8, 2018
    Applicants: Exact Sciences Corporation, Mayo Foundation for Medical Education and Research
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Douglas W. Mahoney, Tracy C. Yab, Graham P. Lidgard, Hatim T. Allawi
  • Isolation of nucleic acids
    Patent number: 9845491
    Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: December 19, 2017
    Assignee: Exact Sciences Corporation
    Inventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
  • SAMPLE COLLECTION DEVICE
    Publication number: 20170333008
    Abstract: Provided herein is technology relating to collecting and preparing samples. For example, the technology relates particularly, but not exclusively, to devices, systems, and kits that allow a subject to collect and prepare a sample for analysis.
    Type: Application
    Filed: August 8, 2017
    Publication date: November 23, 2017
    Inventors: Graham P. Lidgard, Michael J. Domanico, Keith Fourrier, James P. Light, II, Scott Castanon, Keith Kopitzke
  • DETECTION OF LUNG NEOPLASIA BY ANALYSIS OF METHYLATED DNA
    Publication number: 20170335401
    Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
    Type: Application
    Filed: March 28, 2017
    Publication date: November 23, 2017
    Inventors: Hatim Allawi, Graham P. Lidgard, Maria Giakoumopoulos, David A. Ahlquist, William R. Taylor, Douglas Mahoney
  • DETECTION OF LUNG NEOPLASIA BY AMPLIFICATION OF RNA SEQUENCES
    Publication number: 20170321286
    Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
    Type: Application
    Filed: May 5, 2017
    Publication date: November 9, 2017
    Inventors: Hatim Allawi, Graham P. Lidgard, Chateen Krueger, Michael W. Kaiser, Tamara J. Sander
  • Multiplexed KRAS mutation detection assay
    Patent number: 9783856
    Abstract: Provided herein is reagent mixture comprising multiplexed amplification reagents and flap assay reagents for detecting, in a single reaction, mutant copies of the KRAS gene that contain any of the 34A, 34C, 34T, 35A, 35C, 35T or 38A point mutations. Methods that employ the reagent mix and kits for performing the same are also provided.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: October 10, 2017
    Assignee: EXACT SCIENCES CORPORATION
    Inventors: Rebecca Oldham-Haltom, Hatim Allawi, Hongzhi Zou, Michael J. Domanico, Graham P. Lidgard
  • Sample collection device
    Patent number: 9750482
    Abstract: Provided herein is technology relating to collecting and preparing samples. For example, the technology relates particularly, but not exclusively, to devices, systems, and kits that allow a subject to collect and prepare a sample for analysis.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: September 5, 2017
    Assignee: EXACT SCIENCES CORPORATION
    Inventors: Graham P. Lidgard, Michael J. Domanico, Keith Fourrier, James P. Light, II, Scott Castanon, Keith Kopitzke
  • Serial isolation of multiple DNA targets from stool
    Patent number: 9657330
    Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting multiple DNA targets from human stool samples.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: May 23, 2017
    Assignee: Exact Sciences Corporation
    Inventors: Graham P. Lidgard, Janelle J. Bruinsma, Michael J. Domanico, Hemanth Shenoi
  • MULTIPLEX AMPLIFICATION DETECTION ASSAY
    Publication number: 20170121757
    Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.
    Type: Application
    Filed: October 26, 2016
    Publication date: May 4, 2017
    Inventors: Graham P. Lidgard, Hatim Allawi
  • ISOLATION AND DETECTION OF DNA FROM PLASMA
    Publication number: 20170121704
    Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.
    Type: Application
    Filed: October 26, 2016
    Publication date: May 4, 2017
    Inventors: Hatim Allawi, Graham P. Lidgard, Brian Aizenstein, Tamara J. Sander, Maria Giakoumopoulos, Michael W. Kaiser, Melissa M. Gray, Abram Michael Vaccaro