Abstract: The invention relates to a polypeptide, such as an Affimer polypeptide, comprising an amino acid sequence having at least 80% identity to amino acid residues 1 to 11, 13 to 15, 17 to 19, 21 to 25, 27 to 28, 35 to 37, 39, 41, 43 to 44, 46 to 47, 49 to 50, 52 to 53, 55 to 58, 63 to 64, 66, 68 to 82, 84 to 85, and 87 to 98 of SEQ ID NO: 1; characterized in that said polypeptide comprises one or mutations relative to SEQ ID NO: 1. The invention also relates to various methods and nucleic acids.

Abstract: A beverage can with an ingredient chamber for storing functional ingredients separately from a base beverage until the beverage can is opened by a consumer. The ingredient chamber may be disposed on a can end of the beverage can. The ingredient chamber may be broken open to release functional ingredients automatically when the beverage can is opened by the consumer. In some embodiments, the ingredient chamber includes a membrane that forms a sealed cavity. In some embodiments, the ingredient chamber includes a deformed cavity of the can end.

Abstract: Techniques for assigning agents to callers that have contacted a contact center by using a communication management system. The techniques include initiating a communication session between a caller and the communication management system, obtaining caller data by obtaining data from the caller in the communication session and/or obtaining data about the caller's historical behavior, identifying an intent of the caller by using the caller data and a trained machine learning model configured to predict intent of callers, identifying, from a plurality of agents, an agent to assign to the caller in the communication session by using the identified intent and an agent performance model configured to rank at least some of the plurality of agents based on a measure of their performance in communication sessions with callers having a same intent as the identified intent, and assigning the identified agent to the caller.

Abstract: A computer system configured to facilitate communications over a plurality of communication platforms includes a chat monitor configured to monitor communications over a plurality of communication platforms; a parser coupled to the chat monitor and configured to detect whether a communication entered into a communication client corresponds to a communication protocol, the communication protocol including a protocol identifier and a plurality of primary protocol elements including a first user identifier and an instrument identifier; a protocol validator coupled to the parser and configured to validate communications corresponding to the communication protocol; and a database coupled to the protocol validator for storing validated communications. Each communication platform may be associated with a plurality of communication clients, and each communication platform may be configured to transmit communications between communication clients associated with the communication platform.

Abstract: In an embodiment, the present invention provides a compound of the formula: or a pharmaceutically acceptable salt thereof, and methods of using this compound for treating type II diabetes mellitus.

Abstract: A computer system configured to facilitate communications over a plurality of communication platforms includes a chat monitor configured to monitor communications over a plurality of communication platforms; a parser coupled to the chat monitor and configured to detect whether a communication entered into a communication client corresponds to a communication protocol, the communication protocol including a protocol identifier and a plurality of primary protocol elements including a first user identifier and an instrument identifier; a protocol validator coupled to the parser and configured to validate communications corresponding to the communication protocol; and a database coupled to the protocol validator for storing validated communications. Each communication platform may be associated with a plurality of communication clients, and each communication platform may be configured to transmit communications between communication clients associated with the communication platform.

Abstract: The invention relates to a polypeptide, such as an Affimer polypeptide, comprising an amino acid sequence having at least 80% identity to amino acid residues 1 to 11, 13 to 15, 17 to 19, 21 to 25, 27 to 28, 35 to 37, 39, 41, 43 to 44, 46 to 47, 49 to 50, 52 to 53, 55 to 58, 63 to 64, 66, 68 to 82, 84 to 85, and 87 to 98 of SEQ ID NO: 1; characterized in that said polypeptide comprises one or mutations relative to SEQ ID NO: 1. The invention also relates to various methods and nucleic acids.

Abstract: The present invention relates to novel cGAS inhibitor compounds, having a formula of: to pharmaceutical compositions comprising the compounds, and to methods of using the compounds and compositions to treat certain pathological conditions such as immune-mediated diseases.

Abstract: The invention relates to a polypeptide, such as an Affimer polypeptide, comprising an amino acid sequence having at least 80% identity to amino acid residues 1 to 11, 13 to 15, 17 to 19, 21 to 25, 27 to 28, 35 to 37, 39, 41, 43 to 44, 46 to 47, 49 to 50, 52 to 53, 55 to 58, 63 to 64, 66, 68 to 82, 84 to 85, and 87 to 98 of SEQ ID NO: 1; characterised in that said polypeptide comprises one or more mutations relative to SEQ ID NO: 1 selected from the group consisting of: T51L, T51V, M65V, N32G, A59I, L38A, V20I, A40I, L38V, A12I, A12V, I16L, V20L, Q26E, E29M, T31K, N32D, N32H, T34V, T34R, T34D, T34P, A40V, Q42D, T45I, T45V, V48E, V48G, V48A, T51F, T51A, A59L, L67I, (V20I, L38A), (V20L, L38A), (V20I, L38V), (V20L, L38V), (E29K, K30E, E33K), (Y54D, T83D, Q86E), (A59L, G60N, D61G, N62K), (A59V, D61N, N62K), (G60N, D61G, N62K), (G60N, ?D61, N62G), ?D61, (A59L, G60N, ?D61, N62G), (A59V, G60N, D61G, N62K), (A59I, G60N, D61G, N62K), (A59I, G60N, ?D61, N62G), (A59V, G60N, ?D61, N62G), (A59V, ?D61), (G60P, ?D61, N62P),

Abstract: The invention provides a conductive circuit which may be applied to a garment, for example a garment for the stimulation of pelvic floor muscles. In the illustrated embodiments in the garment comprises a pair of shorts. The shorts are made from stretch fabric comprising a polyamide and are designed to fit closely to the body. The shorts are provided with two legs and a waistband area. The shorts comprise left and right conductive circuits, each of which comprises one or more electrodes formed from a printed conductive layer.

Abstract: The invention provides a conductive circuit which may be applied to a garment, for example a garment for the stimulation of pelvic floor muscles. In the illustrated embodiments in the garment comprises a pair of shorts. The shorts are made from stretch fabric comprising a polyamide and are designed to fit closely to the body. The shorts are provided with two legs and a waistband area. The shorts comprise left and right conductive circuits, each of which comprises one or more electrodes formed from a printed conductive layer.

Abstract: Copolymer additives for crude oils, crude oil mixtures of the copolymer additives and crude oils, and methods for producing or forming the crude oil mixtures are provided. The crude oil mixtures and methods comprise at least copolymer additive introduce or applied to crude oil, wherein the at least one copolymer additive comprises one or more copolymers of vinylpyrrolidone and one or more alpha-olefins.

Abstract: An electromagnetic actuator includes an inner magnet arranged relative to an axis, an outer magnet arranged a radial distance from the axis, an inner radial wall of the outer magnet facing an outer radial wall of the inner magnet, the inner and outer radial walls being separated by an air gap, a voice coil arranged in the air gap separating the inner and outer magnets, and an actuator coupling plate attached to the voice coil. During operation of the device electrical activation of the voice coil causes axial motion of the actuator coupling plate.

Abstract: A beverage can with an ingredient chamber for storing functional ingredients separately from a base beverage until the beverage can is opened by a consumer. The ingredient chamber may be disposed on a can end of the beverage can. The ingredient chamber may be broken open to release functional ingredients automatically when the beverage can is opened by the consumer. In some embodiments, the ingredient chamber includes a membrane that forms a sealed cavity. In some embodiments, the ingredient chamber includes a deformed cavity of the can end.

Abstract: An electronic tokening system implemented by a data source transmits secure electronic tokens including time-based values to a plurality of terminals. The terminals may be geographically disparate, and the different terminals may have different connection speeds to the data source. The terminals may use the secure electronic tokens to consistently and reliable calculate data values.

Abstract: An example aspiration system includes an inner member configured to be received within an aspiration catheter lumen and disrupt a thrombus positioned within vasculature of a patient. The inner member includes a distal member at a distal portion of an elongated support member, where the distal member is configured to fit within the aspiration catheter lumen. The distal member defines a larger cross-sectional dimension than the elongated support member, the cross-section being taken in a direction orthogonal to a longitudinal axis of the support member, and is configured to be deployed distally outward from a distal opening of the aspiration catheter lumen to contact and disrupt a thrombus to facilitate the efficiency of a medical aspiration procedure. The distal member may include one or more tapered portions and a surface disruption configured to aid with the thrombus disruption.

Abstract: An electronic tokening system implemented by a data source transmits secure electronic tokens including time-based values to a plurality of terminals. The terminals may be geographically disparate, and the different terminals may have different connection speeds to the data source. The terminals may use the secure electronic tokens to consistently and reliable calculate data values.

Abstract: An electromagnetic actuator includes an inner magnet arranged relative to an axis, an outer magnet arranged a radial distance from the axis, an inner radial wall of the outer magnet facing an outer radial wall of the inner magnet, the inner and outer radial walls being separated by an air gap, a voice coil arranged in the air gap separating the inner and outer magnets, and an actuator coupling plate attached to the voice coil. During operation of the device electrical activation of the voice coil causes axial motion of the actuator coupling plate.

Abstract: Citrate polyester additives for crude oils, mixtures of the citrate polyester additives and crude oils, and methods for producing or forming the mixtures are provided. The mixtures and methods comprise at least one citrate polyester additive introduce or applied to crude oil, wherein the at least one citrate polyester additive comprises one or more citrate crosspolymers.

Abstract: An electromagnetic actuator includes an inner magnet arranged relative to an axis, an outer magnet arranged a radial distance from the axis, an inner radial wall of the outer magnet facing an outer radial wall of the inner magnet, the inner and outer radial walls being separated by an air gap, a voice coil arranged in the air gap separating the inner and outer magnets, and an actuator coupling plate attached to the voice coil. During operation of the device electrical activation of the voice coil causes axial motion of the actuator coupling plate.