Patents by Inventor Graham Smith

Graham Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190270737
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Application
    Filed: May 20, 2019
    Publication date: September 5, 2019
    Applicant: Pfizer Inc.
    Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
  • Patent number: 10391826
    Abstract: A gangway for connecting a first car with a second car and allowing passage of passengers from the first car to the second car, has a first hoop for attaching the gangway to the first car, a second hoop for attaching the gangway to the second car, a third hoop and a fourth hoop, the third and fourth hoops being arranged between the first hoop and the second hoop. A connection element is arranged between the third hoop and the fourth hoop and elastically connects the third hoop to the fourth hoop.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: August 27, 2019
    Assignee: Dellner Couplers AB
    Inventor: Graham Smith
  • Publication number: 20190248890
    Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.
    Type: Application
    Filed: February 8, 2019
    Publication date: August 15, 2019
    Applicant: UCB Biopharma SPRL
    Inventors: Helene Margaret Finney, Alastair David Griffiths Lawson, Stevan Graham Shaw, Bryan John Smith, Kerry Louise Tyson, Lara Kevorkian, Christoph Meier, Kaushik Sarkar, Paul Alan Atherfold
  • Patent number: 10358600
    Abstract: A polymerizable LC material comprising at least one di- or multireactive mesogenic compound selected from the group of compounds of formula I, at least one monoreactive mesogenic compound selected from the group of compounds of formula II, wherein the parameter A11 to A21, L21, p, P11 to P22, R21, Sp11 to Sp21, X11 to X21, and Z11 to Z21 have one of the meanings as given in claim 1, and at least one carbazole oxime ester photoinitiator. Furthermore, a method for preparation of the polymerizable LC material, a polymer film with improved thermal durability obtainable from the corresponding polymerizable LC material, a method of preparation of such polymer film, and the use of such polymer film and said polymerizable LC material for optical, electro-optical, decorative or security devices.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: July 23, 2019
    Assignee: Merck Patent GmbH
    Inventors: Stephen Mulcahy, Iain Gardiner, Jack Bradford, Eduardo Beltran Gracia, Graham Smith
  • Publication number: 20190218217
    Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
    Type: Application
    Filed: March 28, 2019
    Publication date: July 18, 2019
    Inventors: Nigel Graham Cooke, Paulo Fernandes Gomes Dos Santos, Nadege Graveleau, Christina Hebach, Klemens Hoegenauer, Gregory John Hollingworth, Alexander Baxter Smith, Nicolas Soldermann, Frank Stowasser, Ross Sinclair Strang, Nicola Tufilli, Anette von Matt, Romain Wolf, Frederic Zecri
  • Patent number: 10336769
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: July 2, 2019
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Graham Beaton, Mi Chen, Timothy Richard Coon, Todd Ewing, Wanlong Jiang, Willy Moree, Martin Rowbottom, Warren Wade, Liren Zhao, Richard Lowe, Nicole Smith, Neil Ashweek, Yun-Fei Zhu
  • Publication number: 20190178839
    Abstract: An elution apparatus and a detection apparatus are described. The elution apparatus includes: a sample trap for trapping a sample; and one or more pumps and/or valves to move a liquid eluent and a liquid eluate, wherein the eluate includes an extracted portion of the sample that is extracted by the eluent. The detection apparatus includes: a capillary having a low-voltage (LV) end portion to receive a sample; and a conductivity detector coupled to a high-voltage (HV) end portion of the capillary to generate signals based on conductivity of a monitored portion of the capillary in the HV end portion, wherein the conductivity detector is electrically isolated from the LV end portion.
    Type: Application
    Filed: August 15, 2017
    Publication date: June 13, 2019
    Inventors: Graham William LYFORD, Michael SMITH, Alistair Stuart WEBB, Adam John CUSICK, Leigh RYAN, Ian Emil SOHN
  • Publication number: 20190133808
    Abstract: Devices to secure the hand of a patient to a limb positioning device while evenly distributing the applied traction load across the patient's hand and wrist are disclosed. The hand is placed in the open position into a soft mitten, while an anatomically-shaped plate is attached to the mitten for supporting the palm of the hand in the open position. Straps are then secured around the patient's wrist and hand. Finally, the entire device is overwrapped an elastic bandage and secured to the limb positioning device. When traction is applied, the shape of the plate, the construction of the mitten, and the straps combine to allow low-contact pressure across the patient's hand and wrist.
    Type: Application
    Filed: November 6, 2018
    Publication date: May 9, 2019
    Applicant: Smith & Nephew, Inc.
    Inventors: Daniel Zahynacz, William D. Obendorf, Graham Smith, Scott Trenhaile
  • Publication number: 20190075741
    Abstract: This invention is a hydroponic appliance that allows users to grow sufficient yields of fresh produce with relatively little maintenance. The appliance incorporates multiple features required for hydroponic plant cultivation into a plug-and-play system with a feedback loop to manage optimal growing conditions, comprising a growing area, a processor, a mixing chamber, and, in embodiments, more than one reservoir. In aspects, the grow area is divided between two or more reservoirs allowing users to stratify their crops or plant different crop types simultaneously. The apparatus and associated method provide the overall system with increased versatility, including removing aspects of day-to-day maintenance. The system automatically regulates the environment in response to various sensor readings. This includes automatically regulating the temperature, humidity, carbon dioxide level, pH level, and/or nutrient concentration. Accordingly, the plants have more optimum conditions for growth.
    Type: Application
    Filed: August 10, 2018
    Publication date: March 14, 2019
    Applicant: Babylon Micro-Farms Inc.
    Inventors: Alexander Olesen, Graham Smith, Sam Korn
  • Publication number: 20190040055
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Application
    Filed: October 11, 2018
    Publication date: February 7, 2019
    Applicant: Pfizer Inc.
    Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
  • Publication number: 20190011834
    Abstract: A photolithiographic method for fabricating bank structures with improved non-wetting properties to form well regions on a substrate using a photoresist composition comprising a cresol novolak resin, a photoactive diazonaphthoquinone sulfonic ester of a polyhydroxybenzophenone compound with at least one free hydroxyl group, and a non-ionic urethane polyglycol fluorosurfactant. Inkjet methods can be used to deposit active materials into the well areas. Color filter arrays and optoelectronic devices such as OLED devices can be made by this method.
    Type: Application
    Filed: July 25, 2016
    Publication date: January 10, 2019
    Inventors: LI WEI TAN, Pawel MISKIEWICZ, Graham SMITH
  • Patent number: 10159504
    Abstract: A surgical assembly, the assembly including a first guidewire, a second guidewire, in which each of the first guidewire and the second guidewire are configured to be received by a bone block, a first suture loop, a second suture loop, a first locking component, and a second locking component, in which the first locking component is coupled to the first suture loop and the second locking component is coupled to the second suture loop.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: December 25, 2018
    Assignee: Smith & Nephew, Inc.
    Inventors: Jeffrey Wyman, Daniel Ellis, Graham Smith, Ettore Taverna
  • Patent number: 10143507
    Abstract: A surgical assembly includes a first guidewire and a second guidewire, in which each of the first guidewire and the second guidewire are configured to be received by a bone block, a first suture loop, a second suture loop, a first locking component, and a second locking component, in which the first locking component is coupled to the first suture loop and the second locking component is coupled to the second suture loop. The locking component has a hole formed therethrough, in which the hole of the locking component is configured to receive the suture, and may be tethered to a suture by knots engaging a counterbore at opposed ends of a bore defined by the hole.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: December 4, 2018
    Assignee: Smith & Nephew, Inc.
    Inventors: Jon-Paul Rogers, Timothy P. Callahan, Jeffrey Wyman, Graham Smith, Daniel B. Ellis, Ettore Taverna
  • Patent number: 10125130
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 13, 2018
    Assignee: Pfizer Inc.
    Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
  • Patent number: 10058352
    Abstract: The methods and devices disclosed herein are effective in the promoting the reattachment of delaminated cartilage to bone. The methods (and related devices) are effective in the removal of the acellular layer of the delaminated cartilage or effective in the indentation of the acellular layer of the delaminated cartilage thereby exposing the underlying chondrocyte cells and thereby allowing the promotion of the reattachment of the delaminated cartilage.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: August 28, 2018
    Assignee: Smith & Nephew, Inc.
    Inventors: Kelsey Jean Carvell, Ruth Cheng, Graham Smith, Drew Burdon, Paul Alexander Torrie
  • Patent number: 10048420
    Abstract: The invention relates to reactive mesogens (RMs) comprising a terphenyl group, to mixtures and formulations comprising them, to polymers obtained form such RMs and RM mixtures, and the use of the RMs, RM mixtures and polymers in optical or electrooptical components or devices, like optical retardation films for liquid crystal displays (LCDs).
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: August 14, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Kevin Adlem, Owain Llyr Parri, Graham Smith, Patricia Eileen Saxton, Mariam Namutebi, Vicki Cook, Joseph Sargent
  • Patent number: 10024810
    Abstract: An analyzer system including an on-belt analyzer having a housing adapted to be positioned across a path of a conveyor belt which carries material to be analyzed, wherein the housing defines a tunnel dimensioned to allow the belt to travel therethrough in suspended relation in order to allow analysis of the material without the belt contacting the analyzer.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 17, 2018
    Assignee: SCANTECH INTERNATIONAL PTY LTD
    Inventors: Andrew Roland Harris, Michael Francis Edwards, Kenneth Graham Smith, Gavin Leith Christie, Nick John Deans
  • Publication number: 20180198412
    Abstract: A pulse generator is disclosed. The pulse generator can include a pulsed switch, such as a diode. The pulsed switched can be connected between an input source, such as an oscillator and a frequency multiplier.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 12, 2018
    Inventors: DAVID ROBERT BOLTON, GRAHAM SMITH
  • Publication number: 20180148648
    Abstract: The invention relates to lateral fluorinated reactive mesogens (RMs) comprising a tolane group, to mixtures and formulations comprising them, to polymers obtained form such RMs and RM mixtures, and the use of the RMs, RM mixtures and polymers in optical or electrooptical components or devices, like optical films for liquid crystal displays (LCDs).
    Type: Application
    Filed: May 2, 2016
    Publication date: May 31, 2018
    Applicant: Merck Patent GmbH
    Inventors: Graham SMITH, Mark GOEBEL, Kevin ADLEM, Sarah WHITEHOUSE, Tara PERRETT
  • Publication number: 20180148441
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Application
    Filed: November 29, 2017
    Publication date: May 31, 2018
    Applicant: PFIZER INC.
    Inventors: Aaron Craig BURNS, Michael Raymond COLLINS, Samantha Elizabeth GREASLEY, Robert Louis Hoffman, Peter Qinhua HUANG, Robert Steven Kania, Pei-Pei KUNG, Maria Angelica LINTON, Lakshmi Sourirajan NARASIMHAN, Paul Francis RICHARDSON, Daniel Tyler RICHTER, Graham SMITH