Abstract: The present invention pertains to compounds of the formula (1) which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitor: wherein: Q is ?O or ?N—S(?O)2—RQ;RQ is —II or optionally substituted C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; Ar is optionally substituted C5-20aryl; RO is an oxy substituent; the bond marked ? is a single bond or a double bond; the bond marked ? is a single bond or a double bond; R3 and R5 are each independently ring substituents; R2 and R6 are each independently ring substituents; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g., cancer), mycobacterial infections (e.g.

Abstract: An advanced floor mat is disclosed. In an embodiment of the present invention, the floor mat includes a cleanable portion. The floor mat may also include a water dissipation component, a water absorbing component, a cushioning component, customized graphics, a transparent cleanable portion, a tacky surface on the cleanable portion, an antibacterial composition, an antifungal composition, and a fragrance. The cleanable portion may be erodible and may include a plurality of cleanable reusable layers. If a tacky surface is included in the floor mat, an anti-slip feature may be associated with the tacky surface to help prevent slipping on a possibly wet tacky surface. Additionally, a sensor system may be included in the floor mat to assist a user in identifying when the floor mat may require cleaning.

Abstract: The present invention pertains to compounds of the formula (I) which are, inter alia, antiprolilferative agents, anticancer agents, anitimycohacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitor: wherein: Q is ═O or ═N—S(═O)2—RQ; RQ is -II or optionally substituted C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; Ar is optionally substituted C5-20aryl; RO is an oxy substituent; the bond marked &agr; is a single bond or a double bond; the bond marked &bgr; is a single bond or a double bond; R3 and R5 are each independently ring substituents; R2 and R6 are each independently ring substituents; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g.

Abstract: An exercise machine includes a frame with a first axle rotatably about a first axis thereof and a pair of drive systems engage the first axle on opposite sides of the frame. Each of the drive systems includes a crank arm connected to the first axle for rotation about the first axis and a second axle defining a second axis and connected to the crank arm for rotation about the first axle. A lever arm is connected to the second axle for rotation about the second axis. A first link is rotatably connected at opposite locations thereon to the frame and the lever arm. A second link is rotatably connected to the lever arm opposite the first link. A third link is rotatably connected to the second link opposite to the lever arm and slidably engages the second axle.

Abstract: An elliptical trainer includes a frame having a post with two handles pivotally connected to the post. A rotary member is rotatably connected to the frame and a first roller and a second roller eccentrically extend from each of two surfaces of the rotary member. Two pedals are respectively connected to the two handles and movably engaged with respective the two second rollers. Two cables each have a first end fixedly connected to respective one of the two pedals and a second end of each of the two cables reeves through respective one of the two first rollers and is connected to the frame.

Abstract: An elliptical trainer includes a frame having a post with two handles pivotally connected to the post. A rotary member is rotatably connected to the frame and a first roller and a second roller eccentrically extend from each of two surfaces of the rotary member. Two pedals are respectively connected to the two handles and movably engaged with respective the two second rollers. Two cables each have a first end fixedly connected to respective one of the two pedals and a second end of each of the two cables reeves through respective one of the two first rollers and is connected to the frame.

Abstract: A method of manufacturing an X-ray device is described including the step of coupling a housing that includes diamond to an anode structure that includes diamond. Further, a target metal may be formed on a tip of the anode structure. An X-ray device is also described including a housing made of diamond, a cathode within the housing, and an anode structure that includes diamond. The anode structure may include conductive diamond, while the housing structure may include high resistivity diamond.

Abstract: A cathode structure comprising a getter material provided with a diamond film. The getter material may include zirconium, vanadium and iron. Cathode structures may have a substantially rounded configuration including a substantially straight portion. Other cathode structures may have a substantially flat portion, with the diamond film covering essentially the entire flat surface. Methods of manufacturing cathode structures may include conditioning the cathode structure by applying a voltage.

Abstract: An advanced floor mat is disclosed. In an embodiment of the present invention, the floor mat includes a cleanable portion. The floor mat may also include a water dissipation component, a water absorbing component, a cushioning component, customized graphics, a transparent cleanable portion, a tacky surface on the cleanable portion, an antibacterial composition, an antifungal composition, and a fragrance. The cleanable portion may be erodible and may include a plurality of cleanable reusable layers. If a tacky surface is included in the floor mat, an anti-slip feature may be associated with the tacky surface to help prevent slipping on a possibly wet tacky surface. Additionally, a sensor system may be included in the floor mat to assist a user in identifying when the floor mat may require cleaning.

Abstract: A method of manufacturing an X-ray device is described including the step of coupling a housing that includes diamond to an anode structure that includes diamond. Further, a target metal may be formed on a tip of the anode structure. An X-ray device is also described including a housing made of diamond, a cathode within the housing, and an anode structure that includes diamond. The anode structure may include conductive diamond, while the housing structure may include high resistivity diamond.

Abstract: A resistance adjusting device for an exercise device includes a magnetic member connected to a surface of a wheel which is driven by a belt and has a shaft extending through a hub thereof. A disk is movably mounted to the shaft and a recess is defined in a first surface of the disk so as to receive a metal board therein which faces the magnetic member. A panel is mounted to the shaft and a cable extends through the panel and is fixedly connected to the disk. A spring is biased between the disk and the panel. The distance between the disk and the wheel is adjusted by pulling the cable. A resistance force between the magnetic member and the metal board is therefore adjusted.

Abstract: A method of manufacturing an X-ray device is described including the step of coupling a housing that includes diamond to an anode structure that includes diamond. Further, a target metal may be formed on a tip of the anode structure. An X-ray device is also described including a housing made of diamond, a cathode within the housing, and an anode structure that includes diamond. The anode structure may include conductive diamond, while the housing structure may include high resistivity diamond.

Abstract: A cathode structure comprising a getter material provided with a diamond film. The getter material may include zirconium, vanadium and iron. Cathode structures may have a substantially rounded configuration including a substantially straight portion. Other cathode structures may have a substantially flat portion, with the diamond film covering essentially the entire flat surface. Methods of manufacturing cathode structures may include conditioning the cathode structure by applying a voltage.

Abstract: A treadmill includes two stands each having a transverse portion and a continuous belt is pivotally connected between the two stands. Each transverse portion has a recess defined radially therein for receiving a wheel therein. The two wheels each have a rotational axis perpendicular to the longitudinal axis of the transverse portion corresponding thereto so that the continuous belt can be folded between the two stands and the folded treadmill can be moved laterally by the two wheels.

Abstract: An apparatus and method for exposing a treatment site in a patient to x-ray radiation is described that uses a pulse voltage source, where the x-ray emitter employs a cold cathode. The invention may further include a current sensor for measuring a current through the x-ray emitter, and, optionally, a current integrator connected to the current sensor. Each voltage pulse may be discontinued when a predetermined amount of charge has passed through the emitter. The step of moving an x-ray emitter past a treatment area at a rate determined by the amount of charge that has passed through the emitter is also described. The present invention also includes an x-ray emitter device with rectangular voltage pulses added to a base direct current voltage. Another step of the invention may be applying a voltage pulse cycle to the x-ray emitter where a duration of the pulse is 2-5 times lower than a thermal relaxation time of an emitter.

Abstract: There are disclosed herein 2-phenylbenzazole compounds having a 3'-substituent and a 4'-NR.sup.2 R.sup.6 substituent in the phenyl group where R.sup.5 and R.sup.6 are each hydrogen or alkyl, or where the $'-NR.sup.5 R.sup.6 substituent is N-acyl (or N-benzoyl). There are also disclosed 2-phenylbenzazole compounds in the form of 4'-N sulphamate salts. Such compounds exhibit significant selective cytotoxic activity in respect of tumor cells and provide potentially useful chemotherapeutic agents for selective treatment of a range of cancers.

Abstract: A foldable weightlifting bench includes a pair of supporting members each have a post and a transverse bar connected to a lower end of the post. A first connecting rod and a second connected rod are respectively connected between the two posts and the two transverse bars. A base member is pivotally connected to the first connecting rod and located between the two posts, the base member having a stand pivotally connected thereto. A retractable device pivotally connected between the second connecting rod and the base member. A link pivotally connected between the stand and the retractable device. The base member is pivoted about the first connecting rod and the retractable device is then extended to support the base member positioned at an upright position.

Abstract: A treadmill exercise device includes two side frames with a plurality of connecting bars connected therebetween. A board is disposed onto the two side frames. Two first supports are respectively disposed to two respective first ends of the two side frames and two second supports are respectively disposed to two respective second ends of the two side frames. A first roller is rotatably disposed between the two first supports and a second roller is rotatably disposed between the two second supports so that a belt is movably wrapped around the two rollers with the board disposed therebelow.

Abstract: An exercise machine has a frame with parallel rails and a glide board slidably mounted upon the frame and having a plurality of wheels defining concave surfaces in rolling engagement upon the parallel rails. The wheels have a relatively hard roller and an outer tire of resilient material defining the concave surface.

Abstract: A foldable weightlifting bench includes two supporting members each have a post and a base member is pivotally connected between the two posts. Each of the posts has a connecting member extending laterally therefrom and the base member has a tube formed to one end thereof so that the tube can be selectably connected between the two connecting members in a first and a second position by extending pins through different holes of the tube and the connecting members. The base member has a stand pivotally connected to the other end thereof so that when the base member is pivoted about the tube to an upright direction, the stand is hung on the second end of the base member by gravity.