Patents by Inventor Graziano Castaldi

Graziano Castaldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF URSOCHOLIC ACID
    Publication number: 20230348949
    Abstract: A microbiological process is provided for the preparation of ursocholic acid, which includes the biotransformation of ?-sitosterol in the presence of specific microorganisms.
    Type: Application
    Filed: July 22, 2021
    Publication date: November 2, 2023
    Inventors: Michele CASTALDI, Graziano CASTALDI
  • Process for the preparation of a sulfur-amine
    Patent number: 10221132
    Abstract: The present invention relates to a process for the synthesis of cysteamine or a salt thereof.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: March 5, 2019
    Assignee: CHEMELECTIVA SRL
    Inventors: Marco Baratella, Mauro Gaboardi, Graziano Castaldi, Erminio Oldani
  • Process for the preparation of sofosbuvir
    Patent number: 10112967
    Abstract: A process for the synthesis of Sofosbuvir is provided comprising the steps of selectively mono-deacetylating a compound of formula (V) enzymatically using a resin supported lipase B derived from Candida Antarctica to obtain a compound formula (IV), then converting the compound of formula (IV) to a compound of formula (II) by reacting the compound of formula (IV) with a compound of formula (III), and then converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: October 30, 2018
    Assignee: HC-PHARMA AG
    Inventors: Mauro Gaboardi, Giuseppe Pallanza, Marco Baratella, Graziano Castaldi, Marta Castaldi
  • PROCESS FOR THE PREPARATION OF A SULFUR-AMINE
    Publication number: 20180111897
    Abstract: The present invention relates to a process for the synthesis of cysteamine or a salt thereof.
    Type: Application
    Filed: October 20, 2017
    Publication date: April 26, 2018
    Inventors: Marco BARATELLA, Mauro GABOARDI, Graziano CASTALDI, Erminio OLDANI
  • SOFOSBUVIR IN CRYSTALLINE FORM AND PROCESS FOR ITS PREPARATION
    Publication number: 20180079771
    Abstract: Sofosbuvir in crystalline Form ?, process for its production and use in pharmaceutical compositions.
    Type: Application
    Filed: November 28, 2017
    Publication date: March 22, 2018
    Inventors: Mauro GABOARDI, Marta CASTALDI, Graziano CASTALDI, Sara HELMY
  • Process for the synthesis of Dapsone and its intermediates
    Patent number: 9845289
    Abstract: A process for the synthesis of Dapsone and intermediates thereof are described.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: December 19, 2017
    Assignee: SEEGPHARM SA
    Inventors: Marco Baratella, Graziano Castaldi, Marta Castaldi, Mauro Gaboardi, Giuseppe Pallanza
  • Sofosbuvir in crystalline form and process for its preparation
    Patent number: 9845335
    Abstract: Sofosbuvir in crystalline Form ?, process for its production and use in pharmaceutical compositions.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: December 19, 2017
    Assignee: HC-PHARMA AG
    Inventors: Mauro Gaboardi, Marta Castaldi, Graziano Castaldi, Sara Helmy
  • PROCESS FOR THE PREPARATION OF SOFOSBUVIR
    Publication number: 20170247404
    Abstract: The present invention relates to a process for the synthesis of Sofosbuvir.
    Type: Application
    Filed: November 22, 2016
    Publication date: August 31, 2017
    Inventors: Mauro GABOARDI, Giuseppe PALLANZA, Marco BARATELLA, Graziano CASTALDI, Marta CASTALDI
  • PROCESS FOR THE SYNTHESIS OF DAPSONE AND ITS INTERMEDIATES
    Publication number: 20170217883
    Abstract: A process for the synthesis of Dapsone and intermediates thereof are described.
    Type: Application
    Filed: July 29, 2015
    Publication date: August 3, 2017
    Inventors: Marco BARATELLA, Graziano CASTALDI, Marta CASTALDI, Mauro GABOARDI, Giuseppe PALLANZA
  • SOFOSBUVIR IN CRYSTALLINE FORM AND PROCESS FOR ITS PREPARATION
    Publication number: 20170051004
    Abstract: Sofosbuvir in crystalline Form ?, process for its production and use in pharmaceutical compositions.
    Type: Application
    Filed: July 29, 2015
    Publication date: February 23, 2017
    Inventors: Mauro GABOARDI, Marta CASTALDI, Graziano CASTALDI, Sara HELMY
  • Retinoid derivatives and process for their preparation
    Patent number: 9549884
    Abstract: Novel retinoic acid derivatives and a process for their preparation are described.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: January 24, 2017
    Assignee: SELEGO AB
    Inventors: Mauro Gaboardi, Graziano Castaldi, Lars Fredriksson
  • Process for the preparation of erlotinib
    Patent number: 9428468
    Abstract: A process for the preparation of Erlotinib is disclosed in which the compound of formula (II) Is reacted with the compound of formula (III) in the presence of trifluoroacetic acid and formamidine acetate, in an aprotic solvent, and the reaction product is subsequently treated with a source of hydrochloric acid in a suitable solvent to give Erlotinib hydrochloride.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: August 30, 2016
    Assignee: CERBIOS-PHARMA SA
    Inventors: Marco Baratella, Giuseppe Pallanza, Mauro Gaboardi, Graziano Castaldi
  • RETINOID DERIVATIVES AND PROCESS FOR THEIR PREPARATION
    Publication number: 20160136076
    Abstract: Novel retinoic acid derivatives and a process for their preparation are described.
    Type: Application
    Filed: June 17, 2014
    Publication date: May 19, 2016
    Inventors: Mauro GABOARDI, Graziano CASTALDI, Lars FREDRIKSSON
  • PROCESS FOR THE PREPARATION OF ERLOTINIB
    Publication number: 20160115137
    Abstract: A process for the preparation of Erlotinib is disclosed in which the compound of formula (II) Is reacted with the compound of formula (III) and the reaction product is subsequently treated with a source of hydrochloric acid in a suitable solvent to give Erlotinib hydrochloride.
    Type: Application
    Filed: October 27, 2015
    Publication date: April 28, 2016
    Inventors: Marco BARATELLA, Giuseppe PALLANZA, Mauro GABOARDI, Graziano CASTALDI
  • INTERMEDIATES USEFUL FOR THE PREPARATION OF SAXAGLIPTIN
    Publication number: 20160107992
    Abstract: Intermediates useful for the synthesis of saxagliptin and their preparationare described.
    Type: Application
    Filed: June 18, 2014
    Publication date: April 21, 2016
    Inventors: Graziano CASTALDI, Giuseppe PALLANZA, Mauro GABOARDI, Marta CASTALDI
  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF DASATINIB
    Publication number: 20150259337
    Abstract: The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.
    Type: Application
    Filed: February 26, 2015
    Publication date: September 17, 2015
    Inventors: Alessandro BARUTO, Mauro GABOARDI, Marta CASTALDI, Graziano CASTALDI
  • Process and intermediates for the preparation of dasatinib
    Patent number: 9115124
    Abstract: The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: August 25, 2015
    Assignee: CERBIOS-PHARMA SA
    Inventors: Alessandro Baruto, Mauro Gaboardi, Marta Castaldi, Graziano Castaldi
  • INTERMEDIATES USEFUL FOR THE SYNTHESIS OF FEXOFENADINE, PROCESSES FOR THEIR PREPARATION AND FOR THE PREPARATION OF FEXOFENADINE
    Publication number: 20130237709
    Abstract: Intermediates useful for the synthesis of fexofenadine, processes for their preparation and processes for the synthesis of fexofenadine are described.
    Type: Application
    Filed: February 21, 2013
    Publication date: September 12, 2013
    Applicant: CHEMELECTIVA S.r.l.
    Inventors: Graziano CASTALDI, Marco BARATELLA, Mauro GABOARDI
  • One step process for preparing cross-linked poly(allylamine) polymers
    Patent number: 8394416
    Abstract: The present invention relates to a novel one step process for preparing cross-linked poly(allylamine) polymers or salts thereof using the novel cross-linking agent of Formula (IV). This invention also relates to the compound of Formula (IV) as well as to a process to obtain it. The cross-linked poly(allylamine) polymers of the invention are useful in medicine as substrate-binding polymers.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: March 12, 2013
    Assignee: Chemo Ibérica, S.A.
    Inventors: Sabrina Bianchi, Valter Castelvetro, Giovanni Marras, Sonja Bellomi, Graziano Castaldi, Gianpiero Ventimiglia
  • Intermediates for the preparation of pramipexole
    Patent number: 8203002
    Abstract: Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: June 19, 2012
    Assignee: Dipharma S.p.A.
    Inventors: Graziano Castaldi, Alberto Bologna, Pietro Allegrini, Gabriele Razzetti, Vittorio Lucchini