Abstract: A process for the preparation of 2-phenyl-imidazo[1,2-a]pyridine-3-acetamides comprises the reaction of a 2-phenyl-imidazo[1,2-a]pyridine with an oxalic ester reactive derivative, followed by reduction of the carbonyl group and reaction with an amine.

Abstract: A process for the preparation of 2-phenyl-imidazo[1,2-a]pyridine-3 -acetamides comprises the reaction of a 2-phenyl-imidazo[1,2-a]pyridine with an oxalic ester reactive derivative, followed by reduction of the carbonyl group and reaction with an amine.

Abstract: A process for the preparation of 2-(2-fluoro-4-biphenyl)propianic acid enantiomers comprising a II order resolution of ketals of formula ##STR1## wherein R.sub.1 ad R.sub.2 have the meanings reported in the description; the asterisk shows the chiral carbon atom and the asymmetric carbon atoms marked by .alpha. and .beta. have both R or S configuration is described.

Abstract: A process is described for preparing a compound of the formula I: ##STR1## or a salt thereof; wherein X is a protecting group and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, C.sub.1-6 alkyl or C.sub.1-6 perfluoroalkyl, R.sub.5 is hydrogen or when n is 1 R.sub.5 taken together with R.sub.3 comprises a double bond; m is 1, 2 or 3; n is 0 or 1, and p is 0, 1 or 2.

Abstract: A process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorination of 5-amino-2,4,6-triiodoisophthalic acid with thionyl chloride in the presence of a suitable solvent characterized in that the reaction is carried out in the presence of catalytic amounts of a tetraalkylammonium salt of formulaR.sub.1 R.sub.2 R.sub.3 R.sub.4 NX (I)wherein X is halogen, mesylate or tosylate; R.sub.1, R.sub.2, R.sub.3 and R.sub.4, the same or different, are C.sub.1 -C.sub.20 alkyl groups so that the total number of carbon atoms of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is higher than 16.The 5-amino-2,4,6-triiodoisophthalic acid dichloride obtained according to the process of the present invention is useful as intermediate in the synthesis of iodinated contrast media.

Abstract: Compounds of formula ##STR1## (wherein Ar, R, R.sub.1 and X have the meaning reported in the description) are useful intermediates for the preparation of a variety of organic compounds, also optically active, like alpha-haloketones, alpha-hydroxyketones or ketals, alpha-arylalkanoic acids.

Abstract: A process is described for the preparation of mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability, of processing for the preparation of pharmaceutical forms and of stability of the pharmaceutical forms that contain it.

Abstract: New compounds of the spiro-indoline-oxazine class possessing photochromatic and photosensitizing charecteristics are definable by the general formula (I): ##STR1## where the substituents R, R.sup.1 -R.sup.7 and A are as defined in the description. The process for preparing the compounds (I) is described, as is their use as photochromic agents able to confer photochromatic characteristics on the articles in which they are incorporated, and as photosensitizing agents.

Abstract: New photochromatic and thermochromatic compounds of the spirooxazepin-oxazine class are definable by the general formula (I): ##STR1## where the substituents R and R.sub.1 -R.sub.12 are as defined in the description.The process for the preparation of the compounds (I) is described, as is their use as photochromatic and thermochromatic agents.

Abstract: A process is described for the preparation of mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability, of processing for the preparation of pharmaceutical forms and of stability of the pharmaceutical forms that contain it.

Abstract: New photochromatic and thermochromatic compounds of the spiro-oxazepin-oxazine class are definable by the general formula (I): ##STR1## where the substituents R and R.sub.1 -R.sub.12 are defined in the description.The process for the preparation of the compounds (I) is described, as is their use as photochromatic and thermochromatic agents.

Abstract: A stereoconvergent process is described for preparing optically active alpha-arylalkanoic acids using as starting substance a diastereoisomeric mixture of ketals of formula ##STR1## in which the substitutents have the meanings given in the description. The described process leads to the formation of a single enantiomer.

Abstract: New photochromatic and thermochromatic compounds of the spiro-oxazepin-oxazine class are definable by the general formula (I): ##STR1## where the substituents R and R.sub.1 -R.sub.12 are as defined in the description.The process for the preparation of the compounds (I) is described, as is their use as photochromatic and thermochromatic agents.

Abstract: A process is described for preparing an intermediate in the synthesis of naproxen.The intermediate, namely the methyl ester of S(+)-2-(5-bromo-6-methoxy-2-naphthyl)-propionic acid or of its 5-chloro analogue, is prepared by preferential crystallization from mixtures with its enantiomer.

Abstract: Compounds are described of formula ##STR1## in which: Ar represents an aryl, possibly substituted;R represents a C.sub.1 -C.sub.4 alkyl;R' represents a hydroxyl, an alkoxy, an amino group possibly mono or di-alkyl substituted, or an O.sup.-- M.sup.+ group where M.sup.+ represents the cation of an alkaline metal;X represents a hydrogen, chlorine, bromine or iodine atom, a hydroxyl, or an acyloxy, alkylsulphonyloxy or arylsulphonyloxy group.The compounds of formula I can be easily transformed into alpha-arylalkanoic acids of formula ##STR2## in which Ar and R have the aforesaid meanings.

Abstract: A stereoselective process is described for preparing optically active alpha,beta-disubstituted carbonyl compounds, comprising forming an acetal between an alpha,beta-unsaturated aldehyde or ketone and tartaric acid or a derivative thereof, halogenating the product thus obtained, and restoring the carbonyl compound.

Abstract: A process is described for the preparation of intermediates useful in the synthesis of Fosfomycin.More particularly, an enantioselective process is described for the preparation of derivatives of (1S,2S)-1,2-dihydroxypropyl-phosphonic acid of formula ##STR1## wherein R.sub.2 and R.sub.3 have the meanings reported in the specification.

Abstract: A stereoconvergent process is described for preparing optically active alpha-arylalkanoic acids using as starting substance a diastereoisomeric mixture of ketals of formula ##STR1## in which the substituents have the meanings given in the description. The described process leads to the formation of a single enantiomer.

Abstract: A new enantioselective process is described for preparing optically active alpha-arylalkanoic acids by:(a) halogenation on the aliphatic carbon atom alpha to the ketal group, of ketals of formula ##STR1## in which Ar represents an aryl, optionally substituted;R represents a C.sub.1 -C.sub.4 alkyl;R.sub.1 and R.sub.2, represent a hydroxy, a O.sup.- M.sup.+, OR.sub.3 or NR.sub.4 R.sub.5 group;the carbon atoms indicated by an asterisk both simultaneously are in (R) or (S) configuration.This reaction is diastereoselective, so that a mixture of alpha-haloketals is obtained in which one of the two epimers prevails, and generally strongly prevails, over the other.(b) rearrangement of the haloketals of formula ##STR2## in which X is Cl, Br or I to alpha-arylalkanoic acids in a single stage or in two successive stages, by way of esters of formula ##STR3## The compounds (A) and (C) are all new compounds. The rearrangement step (b) may be performed under new, inventive conditions.

Abstract: A process is described for preparing optically active alpha-arylalkanoic acids consisting of rearranging an optically active ketal of formula ##STR1## in which the substituents have the meaning given in the description of the invention.