Abstract: A network interface is described in which a single computer bus is split over a long distance into two or more inter-communicating buses. On one bus, processing and applications are provided and on the other remote bus, peripheral and local controllers are provided. The buses communicate through a series of: bridge, FPGA, FPGA and bridge. Between the FPGAs, a communication path provides long distance communication.

Abstract: Control of AMPK activity enables interventions that modulate lifespan regulation. Agents which alter lifespan regulation of a cell or organism are identified by screening for compounds that regulate AMPK activity or AMPK pathway activity. The agents so-identified and compounds known to alter AMPK pathway activity can be administered to a subject, e.g., to alter lifespan regulation in the subject or to affect a longevity-associated disorder, or a risk, symptom, predisposition thereof.

Abstract: A network interface is described in which a single computer bus is split over a long distance into two or more inter-communicating buses. On one bus, processing and applications are provided and on the other remote bus, peripheral and local controllers are provided. The buses communicate through a series of: bridge, FPGA, FPGA and bridge. Between the FPGAs, a communication path provides long distance communication.

Abstract: This application presents the discovery that the Vitamin D3 receptor (VDR), a member of the nuclear hormone ligand-activated receptor superfamily, interacts with a MNAR, a scaffolding protein. This interaction results in the formation of a ternary complex between VDR, MNAR, and the Src or PI3 kinase families of tyrosine kinases to mediate cell signaling, especially in osteoblast cells.

Abstract: A network interface is described in which a single computer bus is split over a long distance into two or more inter-communicating buses. On one bus, processing and applications are provided and on the other remote bus, peripheral and local controllers are provided. The buses communicate through a series of: bridge, FPGA, FPGA and bridge. Between the FPGAs, a communication path provides long distance communication.

Abstract: A network interface is described in which a single computer bus is split over a long distance into two or more inter-communicating buses. On one bus, processing and applications are provided and on the other remote bus, peripheral and local controllers are provided. The buses communicate through a series of: bridge, FPGA, FPGA and bridge. Between the FPGAs, a communication path provides long distance communication.

Abstract: A split computer (122) comprises a main module (140) remotely connected by external PCI bus (170) to a input/output (I/O) or extension module (142). The main module (140) comprises a processor (181) and an external PCI bus first interface (300). The input/output (I/O) module comprises one or more input and/or output device controllers and an external PCI bus second interface. The external PCI bus connects the external bus first interface of the main module with the external bus second interface of the input/output (I/O) module. The main module executes application programs, maintains user configurations, and maintains application configurations. Yet since the main module is located remotely, e.g., at a data center (150), the both security and centralized management are realized using existing hardware and software. The input/output (I/O) module has a relative small footprint and primarily performs input and output operations.

Abstract: A network interface is described in which a single computer bus is split over a long distance into two or more inter-communicating buses. On one bus, processing and applications are provided and on the other remote bus, peripheral and local controllers are provided. The buses communicate through a series of: bridge, FPGA, FPGA and bridge. Between the FPGAs, a communication path provides long distance communication.

Abstract: A network interface is described in which a single computer bus is split over a long distance into two or more inter-communicating buses. On one bus, processing and applications are provided and on the other remote bus, peripheral and local controllers are provided. The buses communicate through a series of: bridge, FPGA, FPGA and bridge. Between the FPGAs, a communication path provides long distance communication.

Abstract: A network interface is described in which a single computer bus is split over a long distance into two or more intercommunicating buses. On one bus, processing and applications are provided and on the other remote bus, peripheral and local controllers are provided. The buses communicate through a series of: bridge, FPGA, FPGA and bridge. Between the FPGAs, a communication path provides long distance communication.

Abstract: A tip assembly for an edge of an implement of a work machine includes an adapter secured to the edge of the implement. The adapter has an adapter aperture extending therethrough. The tip assembly also includes an implement tip having a tip aperture extending therethrough, the implement tip is positioned relative to the adapter such that the adapter aperture and the tip aperture align to form a passageway. The tip assembly further includes a sleeve subassembly positioned within the passageway. The sleeve subassembly includes (i) a first member, (ii) an intermediate member, and (iii) a second member. In addition, the tip assembly includes a fastener mechanically coupled to the sleeve subassembly wherein rotation of the fastener causes (i) the intermediate member to move in a first direction, and (ii) the first and second members to move in a second direction so as to tightly secure the sleeve subassembly within the adapter aperture.

Abstract: A surgical retractor, retainer, tensioner, tenaculum, spreader or stabilizer (10) useful in open surgical procedures, or in laparoscopic or other endoscopic procedures, includes a plurality of tissue-engaging elements (12, 14) (such as a plurality of atraumatic hooks (18)) connected by a central elastic member (16). The elastic member (16) is preferably composed of a medical grade rubber, silicone or fluoropolymer elastomer, and is preferably configured or shaped as an O-ring (22) or regular polygon (66, 74, 88, or 92). When the retractor (10) is intended and particularly adapted for use in laparoscopic or other endoscopic procedures, the elastic member (16) is collapsible in a direction transverse to an imaginary line drawn between the plurality of tissue engaging elements (12, 14), so as to allow the retractor (10) to be passed through a surgical cannula into and out of the patient's body during the procedure.