Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature of each heater electrode by determining the resistance of each heater electrode.

Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.

Abstract: Requests for data received from multiple subscribers are accessed. At least some of the requests for data originate from one or more addresses associated with a particular subscriber of the multiple subscribers. The accessed requests for data are organized into sets of requests based on the one or more addresses such that a set of requests corresponds to the particular subscriber, and a characteristic of the particular subscriber is determined based on aspects of the set of requests corresponding to the particular subscriber and a behavior model.

Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one aspect, the present invention provides a method for controlling the temperature of a heater electrode associated with a microfluidic channel of a microfluidic device, wherein power applied to the heater electrode is regulated by varying the duty cycle of a pulse width modulation (PWM). In another aspect, the present invention a controller configured to compute the temperature of the heater electrode during the power-on portion of the duty cycle and the during the power-off portion of the duty cycle and to adjust the duty cycle as necessary to achieve a desired temperature in the heater electrode.

Abstract: A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.

Abstract: Requests for data received from multiple subscribers are accessed. At least some of the requests for data originate from one or more addresses associated with a particular subscriber of the multiple subscribers. The accessed requests for data are organized into sets of requests based on the one or more addresses such that a set of requests corresponds to the particular subscriber, and a characteristic of the particular subscriber is determined based on aspects of the set of requests corresponding to the particular subscriber and a behavior model.

Abstract: A method and system for coupling a riser to a subsea wellhead are disclosed. A first terminal end of a riser comprised of an inner riser and an outer riser is coupled to the platform and a second terminal end of the riser is coupled to a wellhead. The second terminal end of the inner riser is coupled to an inner drilling riser tie-back connector (“ITBC”) having a main body. The ITBC is landed on a landing shoulder disposed within the subsea wellhead. A downward weight is applied to the main body. The application of the downward weight to the main body couples the ITBC and the subsea wellhead.

Abstract: Embodiments are disclosed for distributing processing tasks during a start up routine for a computing device between a central processing unit (CPU) and a graphics processing unit (GPU). In some embodiments, a method of loading an operating system for a computing device with a CPU includes receiving power from a power supply and locating a master boot record in a non-volatile storage device. The method further includes copying a first portion of a compressed operating system image from an address indicated by the master boot record to a location in a volatile storage device and instructing a GPU to decompress the first portion of the compressed operating system image in the volatile storage device.

Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.

Abstract: A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.

Abstract: The present invention relates to systems and methods of monitoring velocity or flow in channels, especially in microfluidic channels. In some embodiments, the present invention relates to systems and methods of monitoring velocity or flow rate in systems and methods for performing a real-time polymerase chain reaction (PCR) in a continuous-flow microfluidic system.

Abstract: An active catheter device is provided. At least one elongate catheter segment includes an elongate flexible tube member defining an axis, and a pair of ferrule members operably engaged with and spaced apart along the tube member. The ferrule members are not rotatable about the axis relative to each other. At least one articulation member is operably engaged with and extends at least between the ferrule members along the tube member. Each articulation member is configured to be actuatable to cause a change in a distance between the ferrule members so as to articulate the tube member. Associated systems and methods are also provided.

Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.

Abstract: Computer-implemented systems for searching within a database, providing searching and scoring exact and non-exact matches of data from a plurality of databases to validate data integrity. Embodiments are described relating to novel systems and methods for validating data. The embodiments create a “consensus value” for various items of data based on information shared by different entities, whose separate data can be used for this purpose whilst maintaining its confidentiality from other entities, who may be business competitors and/or who for various reasons should preferably not be given access to the data. Use of consensus value validation provides significant advantages over today's methodology of reliance on outside data vendors to provide purportedly fact-checked clean data.

Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.

Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.

Abstract: The present invention relates to methods for amplifying nucleic acids in micro-channels. More specifically, the present invention relates to methods for performing a real-time polymerase chain reaction (PCR) in a continuous-flow microfluidic system and to methods for monitoring real-time PCR in such systems.

Abstract: A system includes a first database to associate a sub-interface identifier with customer information, a second database to store a history of customer usage records, and a first device. The first device may receive information from a routing device, where the information includes the sub-interface identifier for a sub-interface of the routing device and information identifying an amount of network traffic received at or transmitted from the sub-interface over a time period, use the sub-interface identifier to obtain the associated customer information from the first database, associate the customer information with the information identifying an amount of network traffic received at or transmitted from the sub-interface over a time period to create a new customer usage record, and store the new customer usage record in the second database.

Abstract: At least one exemplary embodiment is directed to an apparatus that includes a microfluidic channel and at least one energy absorbing element, where the energy absorbing element is configured to absorb at least a portion of an incident electromagnetic radiation. The absorption of the radiation by the energy absorbing element varies the temperature of a sample in the microfluidic channel.

Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.