Abstract: Implementations are disclosed to automatically evaluate, detect, or predict an event, and provide customized virtual assistance to a user based on the event. The implementations include a system capable of pulling data from a client device, detecting an event based on the pulled data, and pushing customized digital resources to the client device based on the detected event.

Abstract: To automate time series forecasting machine learning pipeline generation, a data allocation size of time series data may be determined based on one or more characteristics of a time series data set. The time series data may be allocated for use by candidate machine learning pipelines based on the data allocation size. Features for the time series data may be determined and cached by the candidate machine learning pipelines. Predictions of each of the candidate machine learning pipelines using at least the one or more features may be evaluated. A ranked list of machine learning pipelines may be automatically generated from the candidate machine learning pipelines for time series forecasting based upon evaluating predictions of each of the one or more candidate machine learning pipelines.

Abstract: A system is provided comprising a robotic instrument for use with a tool. In some versions, the robotic instrument comprises a hand-held portion to be held by a user and a tool support movably coupled to the hand-held portion to support the tool. The robotic instrument further includes an actuator assembly operatively attached to the tool support and the hand-held portion and configured to move the tool support relative to the hand-held portion in a plurality of degrees of freedom. The robotic instrument may includes a handle alignment member extending from the hand-held portion. At least a portion of the handle alignment member and a tool plane defined by the tool are aligned when the tool support has an optimal range of motion relative to the hand-held portion.

Abstract: Compositions comprising an iboga alkaloid and a cardioprotective agent are provided. Use of the compositions in treating neuropsychiatric disorders are described, where the cardioprotective agent is administered before, during and/or after the iboga alkaloid.

Abstract: Methods for treating a neuropsychiatric disorder by administering an iboga alkaloid and a cardioprotective agent in conjunction with analysis of brain image data is described. Also described are methods to improve brain health and to slow or reverse brain aging by disorder by administering an iboga alkaloid and a cardioprotective agent, where analysis of brain image data is used to monitor and/or evaluate treatment effectiveness.

Abstract: An air handling unit (AHU) for a heating, ventilation, air conditioning, and refrigeration (HVACR) system includes a housing and a combustion heater disposed within the housing. The housing includes a combustion section with a first channel and a second channel. The combustion heater includes heat exchanger tubes and a tube support that supports heat exchanger tubes within the combustion section. The tube support slidably disposed in the first channel and the second channel. The combustion heater configured to be slidably removable from the AHU. An AHU for an HVACR system includes a housing with a fan section and a fan assembly disposed within the housing. The fan assembly including a pair of grooves slidably disposed on a pair of rails of the housing. The fan assembly configured to be both slidably removable from the AHU and liftably removable from the AHU.

Abstract: A method for treating a patient using a catheter insertion device. The catheter insertion device includes a housing, a needle, a catheter, a guidewire, and a thumbwheel. The needle extends through the catheter such that a distal end of the needle extends distal of a distal end of the catheter. The guidewire is coupled to the thumbwheel such that rotation of the thumbwheel advances a distal end of the guidewire through a lumen of the needle. The method includes holding the catheter insertion device, inserting the distal end of the needle and catheter into a blood vessel, rotating the thumbwheel to advance the distal end of the guidewire out of the lumen of the needle into the blood vessel, moving the catheter over the guidewire in the blood vessel, and removing the needle and the guidewire from the catheter.

Abstract: An apparatus and method relating to a cooling hole of a component of a turbine engine. The cooling hole can extend from an inlet to an outlet to define a connecting passage. The cooling hole can contain a diffusing section. The diffusing section can be defined by an interior surface having variable geometries.

Abstract: Components for valve treatment systems are disclosed. Valve treatment systems can include a delivery system for an implantable device. The delivery system can include one or more of clasp control components slidably disposed on a catheter handle, a control element for opening and closing the implantable device, a catheter assembly with features to reduce friction with another catheter assembly, grips for attaching catheter assemblies to clamps, catheter assemblies with features that stiffen or provide variable stiffness, and catheter assemblies with one or more steering control lumens incorporated into a reinforcement layer.

Abstract: This application is directed to a surveillance camera system including a magnet mount for physically receiving a camera module. The camera module includes a housing having an exterior surface of a first shape. A surface of the magnet mount has a second shape that is substantially concave and complementary to the first shape, and is configured to engage the exterior surface of the housing of the camera module. A magnetic material is disposed inside the magnet mount and configured to magnetically couple to a magnetic material of the camera module. A friction pad is embedded on the surface of the magnet mount, has a substantially concave shape and protrudes beyond the second surface. The friction pad is configured to come into contact with the exterior surface of the housing of the camera module at least via a peripheral edge of the substantially concave friction pad.

Abstract: The invention provides compositions and methods comprising biomarker genes for identifying subjects that will respond to human MAP kinase kinase (MEK) inhibitor therapies, compositions and methods comprising biomarker genes for identifying subjects that will respond to MEK inhibitor/target of rapamycin complex (TORC) inhibitor combination therapies, and compositions and methods comprising biomarker genes for identifying subjects that will respond to MEK inhibitor/chemotherapy combination therapies.

Abstract: The present disclosure provides a method for determining a genotype of one or more biomarker genes in a tumor sample of a subject afflicted with cancer, the method comprising determining a genotype of one or more biomarker genes in the tumor sample and classifying a subject as sensitive or resistant to a therapy comprising a SHP2 inhibitor based on the genotype the one or more biomarker genes in the tumor sample.

Abstract: The present invention is for an autonomous aerial vehicle that enables near real-time and offline data processing among heterogenous devices that are in unreliable or unconnected network service areas, wherein the heterogenous devices are associated with heavy industrial systems. The autonomous aerial vehicle may obtain data from a first physical asset, and segment the obtained data as suitable for a local area compute node and/or a cloud compute node. The autonomous aerial vehicle may identify a location associated with the one or more destination devices and may compute a flight path to the destination location. The aerial device may thereafter travel to the destination location and upload relevant data to the at least one destination upon arrival.

Abstract: A vehicle includes an engine, an electric machine, a torque converter, a weldment, an engine disconnect clutch, and a torque converter lockup clutch. The engine has a crankshaft. The electric machine has a rotor. The torque converter has an impeller and a turbine. The weldment is configured to rotate about an axis and to transfer power from the crankshaft and the rotor to the impeller. The weldment has a first hub, a second hub, a torque converter cover, an impeller housing, and a third hub. The engine disconnect clutch is configured to rotatably connect and disconnect the crankshaft to and from the weldment. The torque converter lockup clutch is configured to rotatably connect and disconnect the turbine to and from the weldment.

Abstract: An apparatus for preparing food is provided, and includes a food chamber sized to receive at least one food item, a cutting structure configured to cut the at least one food item when pressed into contact therewith, an impeller for impelling the at least one food item into contact with the cutting structure, a liquid chamber for storing a liquid, a heating system for heating the liquid, and a liquid introduction system in communication with the liquid chamber, the liquid introduction system being operable to introduce at least one of a liquid mist and a liquid spray in the food chamber.

Abstract: Obtaining location data in a novel way is considered to be a part of this invention. An exemplary method for doing so includes identifying first positioning information for a data delivery vehicle based at least in part on a plurality of positioning signals received at the data delivery vehicle from a set of satellites of a global navigation satellite system (GNSS). The example method comprises obtaining relative position information associated with a position vector from the data delivery vehicle to a remote vehicle, the remote vehicle being unable to receive the plurality of positioning signals from the set of satellites. The example method comprises determining second positioning information for the remote vehicle based at least in part on the first positioning information and the relative position information. The example method comprises transmitting the second positioning information to the remote vehicle.

Abstract: Disclosed herein are systems and methods for enabling at least one autonomous device to traverse a three-dimensional space. An example system may comprise a first autonomous vehicle comprising a first sensor suite. The first autonomous vehicle may traverse the three-dimensional space in accordance with a path planned vector. The path planned vector may be dynamically updated based on a first vector associated with a first object identified based on data received from the first sensor suite. The example system may comprise a first aerial vehicle comprising a second sensor suite. The first aerial vehicle may traverse the three-dimensional space based on at least one of data provided by the second sensor suite, the first sensor suite, and other aerial vehicles. The path planned vector may be dynamically updated based on data received from at least one of the first sensor suite, the second sensor suite, and cloud interface data.

Abstract: Method(s) include projecting a support toolpath into a current layer of a model, removing any pieces within an expanded version of a current boundary of the model, generating a support toolpath for the current layer, adding a height increase to portion(s) of model toolpath(s) for the higher layer of the model that overlie the support toolpath generated for the current layer, connecting the support toolpath and the projected support toolpath to form a connected support toolpath, overlaying the connected support toolpath with a next boundary of the model in a lower layer of the model, adding a height increase to portion(s) of the connected support toolpath that fall within the next boundary of the model in the lower layer of the model, and repeating the process through layers of the model to form support toolpaths for support walls for the object to be manufactured by the extrusion printer.

Abstract: The present disclosure is directed to compounds of Formula (I), or pharmaceutically acceptable salts thereof and compounds of Formula (II), or pharmaceutically acceptable salts thereof, that modulate stimulator of interferon genes (STING), compositions comprising such compounds, and methods of using same for the treatment of disorders such as cancer and autoimmune disease.

Abstract: A transmission including an electric machine, a torque converter and a planetary gearset in a transmission housing that is connected to an engine. A turbine shaft is configured to transfer torque from the engine and the electric machine to the planetary gear set. A disconnect clutch selectively couples the input shaft from the engine to the torque converter housing of the torque converter. The disconnect clutch includes a disconnect clutch piston and a first balance dam. A torque converter clutch selectively connects the torque converter housing to the turbine and the turbine shaft. The torque converter clutch includes a torque converter clutch piston and a second balance dam. Ports in the housing permit automatic transmission fluid to flow between the turbine shaft and the torque converter clutch piston; the turbine shaft and the torque converter clutch piston; and the turbine shaft, the first balance dam, and the second balance dam.