Patents by Inventor Gregory A. Reid

Gregory A. Reid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETICALLY MODIFIED ORGANISMS FOR THE PRODUCTION OF STEROID DERIVATIVES
    Publication number: 20240102073
    Abstract: Provided are biosynthetic processes for producing sterol derivatives, and to non-naturally occurring organisms capable of producing sterol derivatives. More specifically, genetically modified non-naturally occurring organisms for producing KCEA, KCDA, and related compounds, from cholesterol, ?-sitosterol, campesterol and their analogs, are provided.
    Type: Application
    Filed: June 8, 2021
    Publication date: March 28, 2024
    Inventors: JAYACHANDRA P. REDDY, J. GREGORY REID, RICHARD REUMERMAN, BERNHARD J. PAUL, URSULA SCHELL
  • Oxysterols and methods of use thereof
    Patent number: 11884697
    Abstract: Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R1, and R5 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: January 30, 2024
    Assignee: Sage Therapeutics, Inc.
    Inventors: Albert Jean Robichaud, Francesco G. Salituro, Gabriel Martinez Botella, Boyd L. Harrison, John Gregory Reid
  • Crystalline 19-nor C3,3-disubstituted C21-n-pyrazolyl steroid
    Patent number: 11884696
    Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: January 30, 2024
    Assignee: Sage Therapeutics, Inc.
    Inventors: Paul Steven Watson, Bret Berner, John Gregory Reid, Jian Wang, James J. Doherty, Stephen Jay Kanes
  • ENZYMATIC METHODS FOR CONVERTING LCA AND 3-KCA TO UDCA AND 3-KUDCA
    Publication number: 20230416800
    Abstract: 7?-hydroxylation systems are provided, as well as methods for producing ?P-hydroxy derivatives of lithocholic acid and 3-keto-lithocholic acid from such systems. Also provided are recombinant organisms useful for the production of such enzymatic systems, and to plasmids that encode for such enzymes.
    Type: Application
    Filed: November 29, 2021
    Publication date: December 28, 2023
    Inventors: J. GREGORY REID, JAYACHANDRA P. REDDY, MATT GREGORY, URSULA SCHELL, BERNHARD J. PAUL
  • CRYSTALLINE 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID
    Publication number: 20230399357
    Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.
    Type: Application
    Filed: August 24, 2023
    Publication date: December 14, 2023
    Inventors: Paul Steven Watson, Bret Berner, John Gregory Reid, Jian Wang, James J. Doherty, Stephen Jay Kanes
  • Generating and conveying comprehensive weather insights at fields for optimal agricultural decision making
    Patent number: 11686880
    Abstract: In an embodiment, a computer-implemented method of generating and displaying a comprehensive depiction of a weather element comprises: based on archived forecast model and observed data, training a machine learning model; calibrating current forecast data by applying the machine learning model to yield a calibrated forecast probability density function; displaying graphical representation of recently observed data and calibrated forecast probability density.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: June 27, 2023
    Assignee: CLIMATE LLC
    Inventors: Frederick Anthony Eckel, Gregory Reid Herman, Christopher Goodman
  • 1,1-disubstituted ethylene process
    Patent number: 11555011
    Abstract: Process for the production of methylidene malonates and cyanoacrylates employing in-situ formed iminium salts derived from acid halides and/or acid anhydrides and N,N,N?,N?-tetra hydrocarbyl diaminoalkanes, the acid halides and/or acid anhydrides being present in a molar excess relative to the diaminoalkanes, as co-reactants with select malonic acid esters and cyanoacetates, respectively.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: January 17, 2023
    Assignee: H.B. Fuller Company
    Inventors: Vijaya Bhasker Gondi, John Gregory Reid
  • METHODS OF MAKING CHOLIC ACID DERIVATIVES AND STARTING MATERIALS THEREFOR
    Publication number: 20220298202
    Abstract: Methods of making cholic acid derivatives, particularly ursodeoxycholic acid, tauroursodeoxycholic acid, 7-ketolithocholic acid, obeticholic acid, their carboxylate salts and carboxylate esters, and starting materials and intermediates therefor.
    Type: Application
    Filed: June 5, 2022
    Publication date: September 22, 2022
    Inventors: J. Gregory Reid, Jayachandra P Reddy, Bernhard J. Paul, Sk Samad Hossain
  • Methods of making cholic acid derivatives and starting materials therefor
    Patent number: 11384116
    Abstract: Methods of making cholic acid derivatives, particularly ursodeoxycholic acid, tauroursodeoxycholic acid, 7-ketolithocholic acid, obeticholic acid, their carboxylate salts and carboxylate esters, and starting materials and intermediates therefor.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: July 12, 2022
    Assignee: Sandhill One, LLC
    Inventors: J. Gregory Reid, Jayachandra P Reddy, Bernhard J. Paul, Sk Samad Hossain
  • A CRYSTALLINE 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID
    Publication number: 20220169674
    Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.
    Type: Application
    Filed: August 6, 2021
    Publication date: June 2, 2022
    Inventors: Paul Steven Watson, Bret Berner, John Gregory Reid, Jian Wang, James J. Doherty, Stephen Jay Kanes
  • METHODS OF MAKING CHOLIC ACID DERIVATIVES AND STARTING MATERIALS THEREFOR
    Publication number: 20220056070
    Abstract: Methods of making cholic acid derivatives, particularly ursodeoxycholic acid, tauroursodeoxycholic acid, 7-ketolithocholic acid, obeticholic acid, their carboxylate salts and carboxylate esters, and starting materials and intermediates therefor.
    Type: Application
    Filed: August 11, 2021
    Publication date: February 24, 2022
    Inventors: J. Gregory Reid, Jayachandra P Reddy, Bernhard J. Paul, Sk Samad Hossain
  • Crystalline 19-nor C3,3-disubstituted C21-N-pyrazolyl steroid
    Patent number: 11236121
    Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and crystalline solid forms and compositions thereof. Also disclosed herein are methods of making crystalline solid forms of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: February 1, 2022
    Assignee: Sage Therapeutics, Inc.
    Inventors: Paul Steven Watson, Bret Berner, John Gregory Reid, Jian Wang, James J. Doherty, Stephen Jay Kanes
  • GENERATING AND CONVEYING COMPREHENSIVE WEATHER INSIGHTS AT FIELDS FOR OPTIMAL AGRICULTURAL DECISION MAKING
    Publication number: 20220018990
    Abstract: In an embodiment, a computer-implemented method of generating and displaying a comprehensive depiction of a weather element comprises: based on archived forecast model and observed data, training a machine learning model; calibrating current forecast data by applying the machine learning model to yield a calibrated forecast probability density function; displaying graphical representation of recently observed data and calibrated forecast probability density.
    Type: Application
    Filed: May 10, 2021
    Publication date: January 20, 2022
    Inventors: Frederick Anthony Eckel, Gregory Reid Herman, Christopher Goodman
  • OXYSTEROLS AND METHODS OF USE THEREOF
    Publication number: 20210261598
    Abstract: Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R1, and R5 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 26, 2021
    Inventors: Albert Jean Robichaud, Francesco G. Salituro, Gabriel Martinez Botella, Boyd L. Harrison, John Gregory Reid
  • Generating and conveying comprehensive weather insights at fields for optimal agricultural decision making
    Patent number: 11009625
    Abstract: In an embodiment, a computer-implemented method of generating and displaying a comprehensive depiction of a weather element comprises: based on archived forecast model and observed data, training a machine learning model; calibrating current forecast data by applying the machine learning model to yield a calibrated forecast probability density function; displaying graphical representation of recently observed data and calibrated forecast probability density.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: May 18, 2021
    Assignee: The Climate Corporation
    Inventors: Frederick Anthony Eckel, Gregory Reid Herman, Christopher Goodman
  • Preparation of bile acids and intermediates thereof
    Patent number: 11008363
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: May 18, 2021
    Assignee: Allergan Sales, LLC
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • Methods for the purification of deoxycholic acid
    Patent number: 10981946
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-?-hydroxysteroids from ?-9,11-ene, 11-keto or 11-hydroxy-?-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: April 20, 2021
    Assignee: Allergan Sales, LLC
    Inventors: Robert M. Moriarty, Achampeta Rathan Prasad, John Gregory Reid, Roy A. Swaringen, Jr.
  • PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF
    Publication number: 20200317716
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Application
    Filed: April 23, 2020
    Publication date: October 8, 2020
    Applicant: ALLERGAN SALES, LLC
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, JR., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • GENERATING AND CONVEYING COMPREHENSIVE WEATHER INSIGHTS AT FIELDS FOR OPTIMAL AGRICULTURAL DECISION MAKING
    Publication number: 20200309994
    Abstract: In an embodiment, a computer-implemented method of generating and displaying a comprehensive depiction of a weather element comprises: based on archived forecast model and observed data, training a machine learning model; calibrating current forecast data by applying the machine learning model to yield a calibrated forecast probability density function; displaying graphical representation of recently observed data and calibrated forecast probability density.
    Type: Application
    Filed: March 26, 2020
    Publication date: October 1, 2020
    Inventors: Frederick Anthony Eckel, Gregory Reid Herman, Christopher Goodman
  • IMPROVED 1,1-DISUBSTITUTED ETHYLENE PROCESS
    Publication number: 20200223790
    Abstract: Improved iminium based processes for the production of cyanoacrylates and methylidene malonates wherein the improvement pertains to the presence of acid chlorides and/or acid anhydrides in the reaction mix.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 16, 2020
    Applicant: OptMed, Inc.
    Inventors: Vijaya Bhasker Gondi, John Gregory Reid