Abstract: The present invention provides pyrimidines of Formula I: wherein R2, R4, R5, R6, R8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

Abstract: This invention relates to a transition metal catalyst compound represented by the formula: LMX2 or (LMX2)2 wherein each M is independently a Group 7 to 11 metal, preferably a Group 7, 8, 9, or 10 metal; each L is, independently, a tridentate or tetradentate neutrally charged ligand that is bonded to M by three or four nitrogen atoms, (where at least one of the nitrogen atoms is a central nitrogen atom and at least two of the nitrogen atoms are terminal nitrogen atoms), and at least two terminal nitrogen atoms are substituted with one C3-C50 hydrocarbyl and one hydrogen atom or two hydrocarbyls wherein at least one hydrocarbyl is a C3-C50 hydrocarbyl, and the central nitrogen atom is bonded to three different carbon atoms or two different carbon atoms and one hydrogen atom; X is independently a monoanionic ligand, or two X may join together to form a bidentate dianionic ligand.

Abstract: An aircraft cabin management system that provides passengers and crew with a number of entertainment and productivity enhancing options. Such options include, without limitation, audio, video, control and status of aircraft data systems and electro-mechanical devices. Located proximate to each seat and in various other strategic locations throughout the cabin is a control unit that acts as the primary means of passenger and crew interaction with the cabin management system. Using a multi-cast distribution methodology, over wired or wireless distribution, allows for an unlimited number of clients to have access to each available audio/video program. This allows the system to be fully scalable from a small 4 seat mobile platform to a large 800+ seat mobile platform. While particularly drawn to aircraft, the cabin management system is also applicable to other venues that have identifiable seating locations such as buses, passenger ships, hotels and auditoriums.

Abstract: A system for capturing flight information such as altitude and airspeed and displaying it in textual format to passengers and crew. Aircraft data is received, parsed and sent over a data network to be received and displayed at passenger seats, galleys and other convenient locations.

Abstract: A computer implemented method, data processing system, and computer program product for monitoring event specification and monitoring event subscription. Monitorable events are defined in a context of execution of a monitored component. Monitorable points of execution of the monitored component are identified, wherein events can be generated from the monitorable points. Possible events that can be generated in the identified monitorable points are then identified to define the monitorable events.

Abstract: This invention relates to transition metal catalyst compounds represented by the formula: LMX2 wherein M is a Group 7 to 11 metal; L is a tridentate or tetradentate neutrally charged ligand that is bonded to M by least three or four nitrogen atoms, and at least one terminal nitrogen atom is part of a pyridinyl ring, a different terminal nitrogen atom is substituted with one C3–C50 hydrocarbyl, and one hydrogen atom or two hydrocarbyls; wherein at least one hydrocarbyl is a C3–C50 hydrocarbyl, and the central nitrogen atom is bonded to at least three different carbon atoms or two different carbon atoms, and one hydrogen atom; X is independently a monoanionic ligand or both X are joined together to form a bidentate dianionic ligand.

Abstract: A method of reducing odors from dewatered biosolids cake includes adding an aluminum-containing compound to digested wastewater sludge prior to dewatering, thereby binding odor-causing proteins with the aluminum-containing compound.

Abstract: This invention relates to a transition metal catalyst compound represented by the formula: LMX2 or (LMX2)2 wherein each M is independently a Group 7 to 11 metal, preferably a Group 7, 8, 9, or 10 metal; each L is, independently, a tridentate or tetradentate neutrally charged ligand that is bonded to M by three or four nitrogen atoms, (where at least one of the nitrogen atoms is a central nitrogen atom and at least two of the nitrogen atoms are terminal nitrogen atoms), and at least two terminal nitrogen atoms are substituted with one C3–C50 hydrocarbyl and one hydrogen atom or two hydrocarbyls wherein at least one hydrocarbyl is a C3–C50 hydrocarbyl, and the central nitrogen atom is bonded to three different carbon atoms or two different carbon atoms and one hydrogen atom; X is independently a monoanionic ligand, or two X may join together to form a bidentate dianionic ligand.

Abstract: Compositions and methods for detecting and treating cancers expressing Mullerian inhibiting substance Type II receptor (MISIIR) are provided.

Abstract: Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: This invention relates to a transition metal catalyst compound represented by the formula: LMX2 or (LMX2)2 wherein each M is independently a Group 7 to 11 metal, preferably a Group 7, 8, 9, or 10 metal; each L is, independently, a tridentate or tetradentate neutrally charged ligand that is bonded to M by three or four nitrogen atoms, (where at least one of the nitrogen atoms is a central nitrogen atom and at least two of the nitrogen atoms are terminal nitrogen atoms), and at least two terminal nitrogen atoms are substituted with one C3-C50 hydrocarbyl and one hydrogen atom or two hydrocarbyls wherein at least one hydrocarbyl is a C3-C50 hydrocarbyl, and the central nitrogen atom is bonded to three different carbon atoms or two different carbon atoms and one hydrogen atom; X is independently a monoanionic ligand, or two X may join together to form a bidentate dianionic ligand.

Abstract: Catalyst systems useful for the polymerisation of 1-olefins are disclosed, which contain nitrogen-containing transition metal compounds comprising the skeletal unit depicted in Formula (B), wherein M is Fe[II], Fe[III], Ru[II], Ru[III] or Ru[IV]; X represents an atom or group covalently or ionically bonded to the transition metal M; T is the oxidation state of the transition metal M and b is the valency of the atom or group X; R1, R2, R3, R4 and R6 are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl; R5 and R7 are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl.

Abstract: This invention relates to transition metal catalyst compounds represented by the formula: LMX2 wherein M is a Group 7 to 11 metal, L is a tridentate or tetradentate neutrally charged ligand that is bonded to M by three or four nitrogen atoms, and at least one terminal nitrogen atom is part of a pyridinyl ring, a different terminal nitrogen atom is substituted with one C3-C50 hydrocarbyl, and one hydrogen atom or two hydrocarbyls; wherein at least one hydrocarbyl is a C3-C50 hydrocarbyl, and the central nitrogen atom is bonded to three different carbon atoms or two different carbon atoms, and one hydrogen atom; X is independently a monoanionic ligand or both X are joined together to form a bidentate dianionic ligand.

Abstract: A complex suitable for the polymerization of l-olefins is disclosed, having the Formula A wherein M is a transition metal, lanthanide or actinide; X represents an atom or group covalently or ionically bonded to the transition metal M; b is the valency of the atom or group X; Z1 is N or P; Z2 is N, P, N−, P−or NR5; Z3 is one of N, P, O, S, NHR3, NR3R4, OH, OR3, SH, SR3, PHR3, PR3R4, (NR3)−, O−, S−, (PR3)−, P(R3R4)O, NR3 or PR3 to the proviso that one of Z2 and Z3 is anionic; T is the oxidation state of the transition metal M when both Z2 or Z3 are neutral, and is one less than the oxidation state of M when one of Z2 or Z3 is anionic; A and B are independently hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl, and may together with Z2 form part of a heterocyclic substituent; B may be joined to Z3 by either a single or a double bond; R1 to R5 are each independently selected from hydrogen, halogen, hydrocarbyl, substitute

Abstract: Catalyst systems useful for the polymerization of 1-olefins are disclosed, which contain nitrogen-containing transition metal compounds comprising the skeletal unit depicted in Formula (B), wherein M is Fe[II], Fe[III], Ru[II], Ru[III] or Ru[IV]; X represents an atom or group covalently or ionically bonded to the transition metal M; T is the oxidation state of the transition metal M and b is the valency of the atom or group X; R1, R2, R3, R4 and R6 are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl; R5 and R7 are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: Catalyst systems for the polymerization or copolymerization of 1-olefins which contain nitrogen-containing transition metal compounds comprising the skeletal unit depicted in formula (B), wherein M is Fe[II] Fe[III], Co[I], Co[II], Co[III], Mn[I], Mn[II], Mn[III], Mn[IV], Ru[II], Ru[III] or Ru[IV]; X is an atom or group covalently or ionically bonded to the transition metal M; T is the oxidation state of the transition metal M and b is the valency of the atom or group X; and R1-R7 are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.