Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: A novel attachment for a microscope to be coupled to an optical coupling tube of a microscope. The attachment for a microscope includes a light source generating a quasi-collimated light output. Elements are provided for reflecting the light output from the light source towards a specimen in the microscope. Further, elements are provided for propagating a reflection of the light output from the light source from the specimen to a viewing point. The elements for achieving the reflecting and the elements for achieving the propagating may each include a spinning Nipkow disk and a dichroic mirror. The quasi-collimated light output from the light source directly impinges on the Nipkow disk, i.e., without being focused on the Nipkow disk and without passing through a lens. A right angle mirror can also be positioned as one of the elements for achieving the reflecting and the propagating.

Abstract: A gas analyzing system that includes a vacuum chamber containing a mass spectrometer and a sampling device for introducing a gas sample into the chamber. A sorption pump is operatively connected to the chamber which is capable of maintaining the chamber at a high vacuum. The pump includes a diffusion barrier that provides smooth pumping characteristics and repeatable short term system behavior when sample pulses are introduced into the system.

Abstract: A brush adapted for cleaning of the teeth, mouth, and gums of the user, comprising a toothbrush handle, ordinary toothbrush bristles affixed to one surface of a brush head at one end of said handle (hereinafter deemed the "brush end") in the usual and customary manner, and shorter, softer bristles, (hereinafter deemed "mouth bristles") for cleaning of the interior of the mouth and for massaging of the gums affixed to all surfaces of the above-mentioned brush head at the brush end of the toothbrush handle.

Abstract: A firearm has an automatic, beyond-center locking toggle action which drives the breach block mechanically. A slide actuator on the firearm responds to the gas pressure generated by the explosion of a cartridge by operating a cam action driver not only to break the lock of the toggle linkage, but also to drive such linkage with positive cam action to withdraw the breach block from the firearm chamber.

Abstract: A new and distinct variety of a Globba hybrid characterized by pink bracts and mostly transparent bracteoles with yellow green and streaked with red purple as within the inflorescence. The foliage displays reddish underleaves.

Abstract: A new and distinct variety of a Globba hybrid characterized by dark pink bracts and cranberry colored bracteoles as within the inflorescence. The foliage displays reddish underleaves.

Abstract: A new and distinct variety of a Globba hybrid characterized by a two-tone blend of pink and white bracts with mostly transparent bracteoles with pink streaking and yellow green tips as within the inflorescence. The foliage displays reddish underleaves.

Abstract: A new and distinct variety of Globba plant characterized by white bracts and divided, mostly transparent bracteoles with upper portion being streaked with red-purple and lower portion with yellow-green. The foliage displays reddish underleaves.