Abstract: Vaccine compositions comprising at least one modified immunogen via in vitro glycosylation methods that provide a rational approach for generating glycosylated versions of immunogens via the reducing end of a linear carbohydrate, the reducing end containing an N-acyl-2-amino moiety. Vaccine compositions comprising a plurality of heterologous immunogens associated with a multivalent carrier, wherein at least one immnunogen is glycosylated. Vaccine compositions comprising multivalent carriers and related methods using the vaccine compositions in various therapeutic and prophylactic applications for inducing an immune response against, treating, or preventing a bacterial, viral, fungal, or protozoan infection.

Abstract: A system and method for an accent lighting system is provided. The system includes a plurality of underwater luminaires each having a plurality of light emitting diodes, and a junction box controller housing a plurality of electrical components for generating electrical signals for controlling the plurality of underwater luminaries. The junction box controller can be mounted to an electrical conduit and a plurality of cables can connect the plurality of underwater luminaires with the junction box controller. An underwater luminaire can include a heat sink and a flexible circuit board having a plurality of light emitting diodes mounted on the heat sink. The flexible circuit board transfers heat from the light emitting diodes to the heat sink. The underwater luminaire can also include a wiring harness for connecting the underwater luminaire to a cable.

Abstract: Disclosed herein are light diffuser devices comprising a sphere having at least two openings, a track, a light source, a cart, and one or more plates, and their methods of use. Also, disclosed here are light diffuser systems comprising a light diffuser device and a portable infrared gas analyzer.

Abstract: Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non-familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.

Abstract: A projectile designed to be lead-free and have a ballistic coefficient ranging from about 0.13 to about 0.80 or greater for enhanced energy/performance at extended ranges may have an elongated body formed with a jacket including a wall having an end defining an ogive portion and a cavity or recess defined within the jacket and in which a core is received. The projectile can be configured in various calibers and sizes. The projectile core may be formed from a plurality of core sections, and at least one of the plurality of core sections may include tungsten powder and a lead-free binder material pressed together to form a substantially cylindrical shape or compact. One or more of the core sections further can be sintered, and the one or more core sections may be received in an end-to-end relationship within the cavity defined by the jacket to form a stacked, sectional core.

Abstract: The present disclosure provides a genetically modified mouse comprising a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of: (a) a genomic nucleic acid encoding mouse ABCA7 modified to include an A 1541 G substitution; (b) a genomic nucleic acid encoding mouse APP modified to include G601R, F606Y, and R609H substitutions; (c) a genomic nucleic acid encoding mouse PLCG2 modified to include a M28L substitution; (d) a genomic nucleic acid encoding mouse MTHFR modified to include a A262V substitution; (e) an inactivated Ceacam1 allele; and (f) an inactivated Il1rap allele. Methods of producing the genetically modified mouse and methods of using the genetically modified mouse are also provided.

Abstract: Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non-familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.

Abstract: A deer carcass transport assembly including a handle member to which are attached two U-shaped hooks in planar relationship, one leg of each hook secured to an end of the handle member, the legs of the U-shaped hook spaced apart sufficiently so as to engage the hind hock of the rear legs of a deer carcass so as to permit the hunter to drag the deer carcass, by means of the hind hooves, from the kill site to a suitable means of transportation.

Abstract: One embodiment of the Touch sensitive impact controlled signal transfer device invention whereas the invention is used as a musical glove device that sends electrical signals to a sound module when areas of the glove containing piezoelectric discs are tapped or otherwise impacted on a surface and where the force applied by impact to the piezoelectric disc or discs is interpreted by the sound module and said module produces a sound at a volume level directly related to the force of impact on the piezoelectric discs and where multiple piezoelectric disks are located in each glove allowing a plurality of sounds by tapping different areas of the glove, such as the palm, thumb and fingers.

Abstract: A deer carcass transport assembly including a handle member to which are attached two U-shaped hooks in planar relationship, one leg of each hook secured to an end of the handle member, the legs of the U-shaped hook spaced apart sufficiently so as to engage the hind hock of the rear legs of a deer carcass so as to permit the hunter to drag the deer carcass, by means of the hind hooves, from the kill site to a suitable means of transportation.

Abstract: There is provided a bulk delivery system for moving bulk material from an elevation below the surface of a host to the host surface. The delivery system includes a storage system mounted on the host surface, a device submersible in the bulk material for lifting the bulk material to the host surface, and a flexible conduit connecting the storage system with the lifting device. The device for lifting the bulk material may be a pump or an eductor. When an eductor is used, a motive conduit is attached to the eductor for introducing a motive product, such as air or previously recovered bulk material into the eductor for drawing the bulk material therein and into the flexible conduit leading to the host surface. The storage system is rotatably mounted on the host for rotation between an operating position in which the flexible conduit and lifting device are located over the bulk material and a storage position in which the flexible conduit and lifting device are stored on the host.

Abstract: The agile information technology infrastructure management system and related methods and processes provide a solution with the required flexibility to effectively and efficiently monitor and manage a wide-variety of disparate information technology and network infrastructure deployed in businesses and enterprises throughout a region or the world.

Abstract: The shoveling hand cart apparatus is a material handling apparatus designed to provide an apparatus that will allow the user easy loading of bulky and heavy items into a wheeled bin by having an open end at or near load/ground height which aids in shoveling/scooping loads in much the way a hand truck operates on boxed loads and allows the user to easily transport contained and loose loads in a bin, and then dump, shovel or slide out the contents of the bin. The shoveling hand cart apparatus is comprised of a handle that has a significant vertical portion prior to the portion that is positioned along the upper part of the sides of the bin in order to permit the operator to work in a comfortable position. The holding area or bin of the cart has a rear arcuate wall and two sides with an open front section. The sides have a vertical dimension that is greater at the area adjacent to the rear arcuate wall and slopes as it goes forward to a smaller vertical dimension.

Abstract: The shoveling hand cart apparatus is a material handling apparatus designed to provide an apparatus that will allow the user easy loading of bulky and heavy items into a wheeled bin by having an open end at or near load/ground height which aids in shoveling/scooping loads in much the way a hand truck operates on boxed loads and allows the user to easily transport contained and loose loads in a bin, and then dump, shovel or slide out the contents of the bin. The shoveling hand cart apparatus is comprised of a handle that has a significant vertical portion prior to the portion that is positioned along the upper part of the sides of the bin in order to permit the operator to work in a comfortable position. The holding area or bin of the cart has a rear arcuate wall and two sides with an open front section. The sides have a vertical dimension that is greater at the area adjacent to the rear arcuate wall and slopes as it goes forward to a smaller vertical dimension.

Abstract: A portable plant chlorophyll imaging system is described which collects light reflected from a target plant and separates the collected light into two different wavelength bands. These wavelength bands, or channels, are described as having center wavelengths of 700 nm and 840 nm. The light collected in these two channels is processed using synchronized video cameras. A controller provided in the system compares the level of light of video images reflected from a target plant with a reference level of light from a source illuminating the plant. The percent of reflection in the two separate wavelength bands from a target plant are compared to provide a ratio video image which indicates a relative level of plant chlorophyll content and physiological stress. Multiple display modes are described for viewing the video images.

Abstract: A plant chlorophyll content meter is described which collects light reflected from a target plant and separates the collected light into two different wavelength bands. These wavelength bands, or channels, are described as having center wavelengths of 700 nm and 840 nm. The light collected in these two channels are processed using photo detectors and amplifiers. An analog to digital converter is described which provides a digital representation of the level of light collected by the lens and falling within the two channels. A controller provided in the meter device compares the level of light reflected from a target plant with a level of light detected from a light source, such as light reflected by a target having 100% reflectance, or transmitted through a diffusion receptor. The percent of reflection in the two separate wavelength bands from a target plant are compared to provide a ratio which indicates a relative level of plant physiological stress.