Abstract: Ultra-high field (“UHF”) magnetic resonance imaging (“MRI”) is used to localize the endopiriform nucleus (“EPN”) as a target for neuromodulation treatment. Single or multiple different image contrasts can be used to guide localization of the EPN. Treatment plan data are generated based on the localized EPN, and may include coordinate data, trajectory data, or both, for delivering neuromodulation treatment to the localized EPN.

Abstract: The present invention comprises implantable neuromodulation systems and methods comprising a protective pouch that at least partially encases an implantable pulse generator prior to implanting in a patient and is adapted to be secured within the surgical site. A lead placement tool configured to receive an electrical lead(s) along at least part of the length of the tool within an open channel or groove to assist in placing electrical leads at the desired target. The lead placement tool may have at least one, or two, angles that provide a bend or angle between first and/or second end regions relative to a straight central region and an open channel along at least one of these regions. A harness for receiving and protecting at least a portion of the length of electrical leads in operative communication with an implantable pulse generator is provided. The harness is adapted to be secured within the surgical site.

Abstract: Systems, devices and methods for implanting neuromodulation systems and, in some cases, spinal fixation systems using a single surgical incision and placing the system components with direct visual and physical access through an open access. Implantable pulse generators of the neuromodulation systems include lead receptacles and, in some cases, the leads may bifurcate into two leads at a proximal side of the leads. Anchors are provided that are capable of anchoring a body of a neuromodulation lead to the rod of a spinal fixation system and/or engaging bone.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open direct visual and/or physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure may be performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: Ultra-high field (“UHF”) magnetic resonance imaging (“MRI”) is used to localize the endopiriform nucleus (“EPN”) as a target for neuromodulation treatment. Single or multiple different image contrasts can be used to guide localization of the EPN. Treatment plan data are generated based on the localized EPN, and may include coordinate data, trajectory data, or both, for delivering neuromodulation treatment to the localized EPN.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open direct visual and/or physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure may be performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides various embodiments of neuromodulation systems, and improvements thereof, capable of being implanted at a spinal treatment site and capable of being implanted at the same time and/or in combination with a spinal procedure being performed at the spinal treatment site. The present invention further includes improvements in the number and types of neuromodulation therapies that can be implanted at the spinal treatment site and improvements to the neuromodulation systems used for delivering such neuromodulation therapies.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a robotic navigation system for identifying a target nerve for guiding and/or performing the implanting a neuromodulation device at the target nerve wherein the neuromodulation device includes a pulse generator and at least one lead in electrical or operative connection with the pulse generator. In some embodiments, the location of the robotically advanced lead and electrode may be imaged and displayed on a display and/or may be visually annunciated using one or more lights to indicate whether the placement location of the lead or electrode is within or outside of a predetermined distance of the target nerve.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that initially comprises spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a lead template for optimal lead placement and spacing during a surgical method and procedure for implantation of a neuromodulation system at a spinal treatment site.

Abstract: The present invention provides an improved lead design and method for optimal lead placement during a single surgical method for implantation at a spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. Electrical fields may be generated and shifted in location to optimize stimulation targeting. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that initially comprises spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for directional coordinated reset deep brain stimulation are provided. In some embodiments, a method is provided, comprising: implanting a lead with segmented electrodes into an anatomical structure; selecting a first subset of the electrodes corresponding to the anatomical structure as active electrodes; causing electrical pulses at a first stimulation level to be applied at the active electrodes in a first sequence; causing electrical pulses at a second stimulation level that is lower than the first stimulation level to be applied at the active electrodes in a second sequence during a second time period; and inhibiting electrical pulses from being applied at inactive electrodes during the second time period.

Abstract: A pain management system includes a spinal stabilization device and a neuromodulation device. The spinal stabilization device includes a rod, a plurality of pedicle screws each having a screw-head defining a screw-head cavity configured to receive a portion of the rod, and a corresponding plurality of inserts configured to engage with the inner wall of the cavity to secure the rod in place in the cavity. The neuromodulation device includes a therapy module comprising electronics packaged within a housing. The housing has a form factor having at least one feature configured to mate with a corresponding feature of the screw-head of one of the plurality of pedicle screws. The respective features mate in a manner that enables the therapy module to mechanically couple to and subsequently decouple from the screw-head of the pedicle screw.

Abstract: The present invention provides various embodiments of neuromodulation systems, and improvements thereof, capable of being implanted at a spinal treatment site and capable of being implanted at the same time and/or in combination with a spinal procedure being performed at the spinal treatment site. The present invention further includes improvements in the number and types of neuromodulation therapies that can be implanted at the spinal treatment site and improvements to the neuromodulation systems used for delivering such neuromodulation therapies.

Abstract: The present invention comprises implantable neuromodulation systems and methods comprising a protective pouch that at least partially encases an implantable pulse generator prior to implanting in a patient and is adapted to be secured within the surgical site. The pouch may be secured to a pedicle screw and/or a fixation rod, or to a vertebral body.

Abstract: The present invention provides various embodiments of neuromodulation systems, and improvements thereof, capable of being implanted at a spinal treatment site and capable of being implanted at the same time and/or in combination with a spinal procedure being performed at the spinal treatment site. The present invention further includes improvements in the number and types of neuromodulation therapies that can be implanted at the spinal treatment site and improvements to the neuromodulation systems used for delivering such neuromodulation therapies.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open direct visual and/or physical access to an identified spinal treatment site that initially comprises spinal levels to be treated, wherein the spinal levels include at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the low-profile pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.