Abstract: A shoelace tightening system for singlehanded tightening of a shoelace on a shoe. The shoelace tightening system includes a shoelace, a pull tab and a fastening system. The shoelace is threaded through eyelets on both sides of the shoe's throat, with a pull tab slidably secured to a continuous free length of shoelace extending between the exit eyelets. The pull tab is operable for pulling the shoelace taut with a single hand, and fastenable to the shoe upper at a location that keeps the shoelace taut.

Abstract: Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.

Abstract: Underground utility enclosure cover assemblies are used with direct burial enclosures. The cover assemblies include a frame and a cover. The frame has one or more walls that define a central opening, a cover receiving ledge, an overhang that has a sidewall, and at least one stabilizing member extending from a bottom edge of the sidewall of the overhang. The cover is dimensioned to rest on the cover receiving ledge. The frame and the cover are made of a rigid material that permits the frame and cover to support large vertical loads.

Abstract: Enclosure cover assemblies for use with direct burial enclosures are provided. The enclosure cover assembly includes a frame that is secured to the enclosure and a cover separately secured to the frame. The frame and cover are made of metal while the enclosure is made of a high strength material.

Abstract: Enclosure cover assemblies for use with direct burial enclosures are provided. The enclosure cover assembly includes a frame that is secured to the enclosure and a cover separately secured to the frame. The frame and cover are made of metal while the enclosure is made of a high strength material.

Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Abstract: Enclosure cover assemblies for use with direct burial enclosures are provided. The enclosure cover assembly includes a frame that is secured to the enclosure and a cover separately secured to the frame. The frame and cover are made of metal while the enclosure is made of a high strength material.

Abstract: Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.

Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Abstract: The present invention is generally related to modified or mutated respiratory syncytial virus (RSV) fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. Specifically, the disclosure provides a method of maternal immunization comprising administering a composition comprising an RSV F protein and an adjuvant to a pregnant woman carrying a gestational infant, wherein the method induces an immune response against at least one symptom associated with RSV lower respiratory tract infection (LRTI) in the infant following birth.

Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Abstract: Precast utility enclosure aprons for buried utility enclosures that have an angled top surface to direct water, ice and debris away from the center of the apron and to limit damage to the apron and utility enclosure caused by impacts to the apron.

Abstract: Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.

Abstract: Disclosed herein are methods and nanoparticles suitable for use in reducing exacerbations in COPD patients. The methods and compositions advantageously reduce the incidence of hospitalization in COPD patients that occurs in response to environmental insults such as exposure to or infection by RSV. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Abstract: Precast utility enclosure aprons for buried utility enclosures that have an angled top surface to direct water, ice and debris away from the center of the apron and to limit damage to the apron and utility enclosure caused by impacts to the apron.

Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Abstract: Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.

Abstract: Precast utility enclosure aprons for buried utility enclosures that have an angled top surface to direct water, ice and debris away from the center of the apron and to limit damage to the apron and utility enclosure caused by impacts to the apron.

Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.