Abstract: Enclosure cover assemblies for use with direct burial enclosures are provided. The enclosure cover assembly includes a frame that is secured to the enclosure and a cover separately secured to the frame. The frame and cover are made of metal while the enclosure is made of a high strength material.

Abstract: Precast utility enclosure aprons for buried utility enclosures that have an angled top surface to direct water, ice and debris away from the center of the apron and to limit damage to the apron and utility enclosure caused by impacts to the apron.

Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Abstract: A light and fan assembly has a generally tubular housing that has a turbine fan located on one end, the fan discharging a stream of air therefrom, and a light located on the opposing end, the light discharging a light beam therefrom in opposite direction to the direction of the air stream. A clip clips the housing to an appropriate surface such as a hat brim. A monocular is attached to the housing. Alternately, the fan can be held within an assembly that is pivotally attached to a lower surface of the housing.

Abstract: The present invention relates generally to the production of energy and the reclamation of carpet waste material. More particularly, the invention relates to a method and system for storing and using post industrial and post consumer carpet as fuel in an energy generation process and for producing at least one recyclable carpet waste material.

Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: The present invention relates generally to the production of energy and the reclamation of carpet waste material. More particularly, the invention relates to a method and system for storing and using post industrial and post consumer carpet as fuel in an energy generation process and for producing at least one recyclable carpet waste material.

Abstract: A light and fan assembly has a generally tubular housing that has a turbine fan located on one end the fan discharging a stream of air therefrom, and a light is located on the opposing end, the light discharging a light beam therefrom in opposite direction to the air stream. A clip clips the housing to an appropriate surface such as a hat brim. The fan can draw air from one of two intakes with one of the intakes allowing air to pass over a heat sink of the light to help cool the light assembly and warm the air stream or resistive heating elements can be provided in order to heat the air stream. A magnifying lens is attached, fixedly or pivotally and possibly rotatably, to the housing.

Abstract: The present invention relates generally to the production of energy and the reclaimation of carpet waste material. More particularly, the invention relates to a method and system for storing and using post industrial and post consumer carpet as fuel in an energy generation process and for producing at least one recyclable carpet waste material.

Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: A dual display mobile device comprises a first device with a first display and a second device with a second display. The mobile device can operate as a mobile cell phone. In a closed configuration of the mobile device, the first display is exposed and the second display is hidden. In an open configuration, both displays are exposed. In a detached configuration, the second device is separated from the first device and the second device can operate as a mobile phone handset. The separated first and second device can communicate wirelessly. The detachable second device allows a user to utilize the full capabilities of the mobile phone without having to remove the second device away from the user's ear, thus preserving the privacy of a phone call. The first and second displays can interact with each other or operate independently in the open, closed or detached configurations.

Abstract: A sun visor extender and CD holder includes a frame and a pair of longitudinal sides. A plurality of notches is formed along a top surface of the sides. Oppositely disposed ends are formed with the sides and oriented orthogonal thereto. Open top and bottom faces define a central region between the sides and the ends. Straps traverse across a width of the frame and are anchored thereto and span subjacent to the top and bottom faces. A storage rack is attached to the frame and has shoulders bulging outwardly from a bottom surface thereof. The rack is oppositely faced from the straps and extends along an entire surface area of the top surface of the frame. A sun-blocking plate has a body interfitted between the sides and the ends and is supported by the straps.

Abstract: A plurality of embodiments of improved ergonomic keyboards for interfacing with a user's arms, wrists, hands and fingers in a more natural way, i.e., in ways that are optimally suited to human typing. In various non-limiting embodiments, the invention provides optimal finger pressing angles, provides optimal range(s) for “gable” angling, flattens the outer edges of the gable, thins key patterns of split key arrangements, raises (or lowers) the wrist rest to an optimal position, and/or splits the wrist rest into two (or more) components.

Abstract: The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.

Abstract: An expandable starch-based composition includes a starch, a volatile blowing agent, a non-volatile plasticizer, nucleating agent, and a water-resistant polymer. The expandable starch-based composition can be characterized by having a plasticized starch capable of expanding when rapidly heated to above the boiling point of the volatile blowing agent and the softening point of the plasticized starch. The composition can be used in a method of manufacturing an expandable starch-based bead, wherein the method includes: introducing the composition into an extruder; heating and mixing the composition in order to yield a thermoplastic melt; extruding the thermoplastic melt through a die opening to yield an extruded strand; cooling the extruded strand; and cutting the cooled strand in to beads.

Abstract: A fiber-reinforced and starch-based composition can be prepared by combining two fractions. The first fraction can include a gelatinized starch, water, and fibers, wherein the fibers are substantially homogenously mixed with the starch in an amount sufficient to structurally reinforce the mechanical characteristics of the starch-based composition. The second fraction is then combined with the first fraction, wherein the second fraction can include non-gelatinized starch, non-volatile plasticizer, and a water-resistant polymer. The composition is mixed so as to form a thermoplastic composition being capable of expanding when rapidly heated to above the boiling point of water and the softening point of the plasticized starch. Additionally, fiber-reinforced articles can be prepared from a method of processing the starch-based compositions. Such a method includes introducing the fiber-reinforced starch-based composition into a mold, and molding the composition into a fiber-reinforced article.

Abstract: A transcutaneous immunization system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses an adjuvant, preferably an ADP-ribosylating exotoxin, to induce an antigen-specific immune response (e.g., humoral and/or cellular effectors) after transcutaneous application of a formulation containing antigen and adjuvant to intact skin of the animal or human. The efficiency of immunization may be enhanced by adding hydrating agents (e.g., liposomes), penetration enhancers, or occlusive dressings to the transcutaneous delivery system. This system may allow activation of Langerhans cells in the skin, migration of the Langerhans cells to lymph nodes, and antigen presentation.