Patents by Inventor Gregory J. Cost

Gregory J. Cost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
    Patent number: 9816074
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic stem cell.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: November 14, 2017
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Anthony Conway, Gregory J. Cost, Philip D. Gregory
  • GENE CORRECTION OF SCID-RELATED GENES IN HEMATOPOIETIC STEM AND PROGENITOR CELLS
    Publication number: 20170189450
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted integration of a functional SCID-related genes (e.g., IL2RG, RAG1 and/or RAG2 gene) into the genome of a cell for provision of proteins lacking or deficient in SCID.
    Type: Application
    Filed: March 14, 2017
    Publication date: July 6, 2017
    Inventors: Anthony Conway, Gregory J. Cost, Michael C. Holmes, Fyodor Urnov
  • Methods and compositions for treatment of a genetic condition
    Patent number: 9650648
    Abstract: Methods and compositions for a genetic disease are provided.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: May 16, 2017
    Assignee: SANGAMO BIOSCIENCES, INC.
    Inventors: Gregory J. Cost, Philip D. Gregory, Dmitry Guschin, Michael C. Holmes, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Lei Zhang
  • Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
    Patent number: 9616090
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted integration of a functional SCID-related genes (e.g., IL2RG, RAG1 and/or RAG2 gene) into the genome of a cell for provision of proteins lacking or deficient in SCID.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: April 11, 2017
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Anthony Conway, Gregory J. Cost, Michael C. Holmes, Fyodor Urnov
  • METHODS AND COMPOSITIONS FOR INCREASING TRANSGENE ACTIVITY
    Publication number: 20160326548
    Abstract: Methods and compositions for increasing transgene expression and/or activity, including for increasing nuclease-mediated genomic modifications.
    Type: Application
    Filed: April 28, 2016
    Publication date: November 10, 2016
    Inventor: Gregory J. Cost
  • METHODS AND COMPOSITIONS FOR INACTIVATING ALPHA 1,6 FUCOSYLTRANSFERASE (FUT8) GENE EXPRESSION
    Publication number: 20160194665
    Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Application
    Filed: March 24, 2016
    Publication date: July 7, 2016
    Inventors: Trevor Collingwood, Gregory J. Cost
  • METHODS AND COMPOSITIONS FOR ENHANCING TARGETED TRANSGENE INTEGRATION
    Publication number: 20160168593
    Abstract: Disclosed herein are methods and compositions for enhancing insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease or a hemophilia by administering one or more topoisomerases inhibitors, one or more stabilizers of R loop formation or inhibitors of R-loop repair and/or one or more up-regulators of the TC-NER pathway to the target cell.
    Type: Application
    Filed: December 14, 2015
    Publication date: June 16, 2016
    Inventors: Gregory J. Cost, Thomas Wechsler
  • TARGETED GENOMIC MODIFICATION WITH PARTIALLY SINGLE-STRANDED DONOR MOLECULES
    Publication number: 20160145644
    Abstract: Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
    Type: Application
    Filed: January 7, 2016
    Publication date: May 26, 2016
    Inventors: Gregory J. Cost, Dmitry M. Guschin, Fyodor Urnov
  • Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression
    Patent number: 9322036
    Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: April 26, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Trevor Collingwood, Gregory J. Cost
  • METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION
    Publication number: 20160090607
    Abstract: Methods and compositions comprising single guide RNAs targeted to endogenous gene for genetic alteration of cells are provided.
    Type: Application
    Filed: December 10, 2015
    Publication date: March 31, 2016
    Inventors: Anthony Conway, Gregory J. Cost, Russell DeKelver, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Jianbin Wang, H. Steve Zhang
  • Targeted genomic modification with partially single-stranded donor molecules
    Patent number: 9255259
    Abstract: Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: February 9, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Gregory J. Cost, Dmitry M. Guschin, Fyodor Urnov
  • GENE CORRECTION OF SCID-RELATED GENES IN HEMATOPOIETIC STEM AND PROGENITOR CELLS
    Publication number: 20160030477
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted integration of a functional SCID-related genes (e.g., IL2RG, RAG1 and/or RAG2 gene) into the genome of a cell for provision of proteins lacking or deficient in SCID.
    Type: Application
    Filed: July 30, 2015
    Publication date: February 4, 2016
    Inventors: Anthony Conway, Gregory J. Cost, Michael C. Holmes, Fyodor Urnov
  • METHODS AND COMPOSITIONS FOR MODULATING NUCLEASE-MEDIATED GENOME ENGINEERING IN HEMATOPOIETIC STEM CELLS
    Publication number: 20160024474
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic stem cell.
    Type: Application
    Filed: July 23, 2015
    Publication date: January 28, 2016
    Inventors: Anthony Conway, Gregory J. Cost, Philip D. Gregory
  • Methods and compositions for modification of the HPRT locus
    Patent number: 9222105
    Abstract: Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: December 29, 2015
    Assignees: Sangamo BioSciences, Inc., The Regents of the University of California
    Inventors: Gregory J. Cost, Michael C. Holmes, Noriyuki Kasahara, Josee Laganiere, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Fyodor Urnov, Lei Zhang
  • Targeted genomic modification with partially single-stranded donor molecules
    Patent number: 9005973
    Abstract: Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: April 14, 2015
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Gregory J. Cost, Dmitry M. Guschin, Fyodor Urnov
  • METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION
    Publication number: 20150056705
    Abstract: Methods and compositions for genetic alteration of cells are provided.
    Type: Application
    Filed: May 15, 2014
    Publication date: February 26, 2015
    Inventors: Anthony Conway, Gregory J. Cost, Russell Dekelver, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Jianbin Wang, H. Steve Zhang
  • Methods and compositions for modification of the locus
    Patent number: 8895264
    Abstract: Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: November 25, 2014
    Assignees: Sangamo BioSciences, Inc., The Regents of the University of California
    Inventors: Gregory J. Cost, Michael C. Holmes, Noriyuki Kasahara, Josee Laganiere, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Fyodor Urnov, Lei Zhang
  • METHODS AND COMPOSITIONS FOR INACTIVATING ALPHA 1,6 FUCOSYLTRANSFERASE (FUT8) GENE EXPRESSION
    Publication number: 20140273097
    Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Application
    Filed: May 28, 2014
    Publication date: September 18, 2014
    Applicant: Sangamo BioSciences, Inc.
    Inventors: Trevor Collingwood, Gregory J. Cost
  • Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression
    Patent number: 8772025
    Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: July 8, 2014
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Trevor Collingwood, Gregory J. Cost
  • METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION
    Publication number: 20140093913
    Abstract: Methods and compositions for a genetic disease are provided.
    Type: Application
    Filed: August 29, 2013
    Publication date: April 3, 2014
    Inventors: Gregory J. Cost, Philip D. Gregory, Dmitry Guschin, Michael C. Holmes, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Lei Zhang