Patents by Inventor Gregory J. Cost

Gregory J. Cost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION
    Publication number: 20140080216
    Abstract: Methods and compositions for a genetic disease are provided.
    Type: Application
    Filed: August 29, 2013
    Publication date: March 20, 2014
    Inventors: Gregory J. Cost, Philip D. Gregory, Dmitry Guschin, Michael C. Holmes, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Lei Zhang
  • METHODS AND COMPOSITIONS FOR DELIVERY OF BIOLOGICS
    Publication number: 20140017214
    Abstract: Nucleases and methods of using these nucleases for genetic alteration of red blood cells (RBCs), for example for providing for a protein lacking in a monogenic disorder or a biologic for the treatment of exposure to a toxin using genetically altered RBCs.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 16, 2014
    Inventor: Gregory J. Cost
  • METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED TARGETED INTEGRATION OF TRANSGENES
    Publication number: 20130326645
    Abstract: Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
    Type: Application
    Filed: May 7, 2013
    Publication date: December 5, 2013
    Applicants: Dow AgroSciences LLC, Sangamo BioSciences, Inc.
    Inventors: Gregory J. Cost, Fyodor Urnov, William M. Ainley, Joseph F. Petolino, Jayakumar Pon Samuel, Steven R. Webb, Lakshmi Sastry-Dent
  • Targeted genomic modification with partially single-stranded donor molecules
    Publication number: 20110287545
    Abstract: Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
    Type: Application
    Filed: July 8, 2011
    Publication date: November 24, 2011
    Inventors: Gregory J. Cost, Dmitry M. Guschin, Fyodor Urnov
  • Targeted genomic modification with partially single-stranded donor molecules
    Publication number: 20110207221
    Abstract: Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
    Type: Application
    Filed: February 9, 2011
    Publication date: August 25, 2011
    Inventors: Gregory J. Cost, Dmitry M. Guschin, Fyodor Urnov
  • Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression
    Publication number: 20110159541
    Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Application
    Filed: January 27, 2011
    Publication date: June 30, 2011
    Inventors: Trevor Collingwood, Gregory J. Cost
  • Methods and compositions for inactivating alpha 1,6 fucosyltransferase () gene expression
    Patent number: 7919313
    Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: April 5, 2011
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Trevor Collingwood, Gregory J. Cost
  • Engineered cleavage half-domains
    Patent number: 7914796
    Abstract: Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising these polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: March 29, 2011
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Jeffrey C. Miller, Michael C. Holmes, Gregory J. Cost
  • Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression
    Publication number: 20090042250
    Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Application
    Filed: July 10, 2008
    Publication date: February 12, 2009
    Inventors: Trevor Collingwood, Gregory J. Cost