Patents by Inventor Gregory Stephanopoulos

Gregory Stephanopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11028413
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: June 8, 2021
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Publication number: 20200283803
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Application
    Filed: March 5, 2020
    Publication date: September 10, 2020
    Applicants: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Patent number: 10676721
    Abstract: The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: June 9, 2020
    Assignees: Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: James J. Collins, Michael Koeris, Timothy Kuan-Ta Lu, Gregory Stephanopoulos, Christopher Jongsoo Yoon
  • Patent number: 10633675
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: April 28, 2020
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Patent number: 10519470
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: December 31, 2019
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Publication number: 20190367950
    Abstract: Disclosed herein are engineered cells and cell-free systems, compositions, and methods for conversion of isopentenols to isoprenoid precursors.
    Type: Application
    Filed: May 29, 2019
    Publication date: December 5, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Steven McBride Edgar, Alkiviadis Orfefs Chatzivasileiou, Valerie Ward, Gregory Stephanopoulos
  • Publication number: 20190153488
    Abstract: A bioconversion scheme is provided that effectively converts syngas, generated from gasification of coal, natural gas or biomass, into lipids that can be used for biodiesel production.
    Type: Application
    Filed: September 6, 2016
    Publication date: May 23, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Peng Hu, Hongjuan Liu
  • Patent number: 10294481
    Abstract: Some aspects provide engineered microbes for glycolate production. Methods for microbe engineering and culturing are also provided herein. Such engineered microbes exhibit greatly enhanced capabilities for glycolate production.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 21, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Zheng-Jun Li, Brian Pereira
  • Patent number: 10227597
    Abstract: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 12, 2019
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Publication number: 20190032003
    Abstract: The disclosure provides methods using mixed substrate cofeeding for bioproduct synthesis, which enables faster, more efficient, and higher yield carbon conversion in various organisms.
    Type: Application
    Filed: June 29, 2018
    Publication date: January 31, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Junyoung Park, Nian Liu, Gregory Stephanopoulos
  • Publication number: 20190017077
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Application
    Filed: July 10, 2018
    Publication date: January 17, 2019
    Applicants: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Patent number: 10174347
    Abstract: Aspects of the invention relate to methods for producing lactic acid from organic waste, comprising contacting organic waste with a microbial community to form a fermentation mixture, and fermenting the fermentation mixture under controlled pH and temperature conditions for a time sufficient to produce lactic acid.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: January 8, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Devin Hedley Currie, Kristen Jean Fortnam
  • Publication number: 20180282766
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Application
    Filed: March 19, 2018
    Publication date: October 4, 2018
    Applicants: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Patent number: 10064885
    Abstract: A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1, isocitrate dehydrogenase 2 (IDH2), aconitase 1 (ACO1), aconitase 2 (ACO2), glutaminase (GLS), glutamate dehydrogenase (GDH) and transaminase, provides effective means of inhibiting tumor growth.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: September 4, 2018
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Gregory Stephanopoulos, Christian M. Metallo, Joanne K. Kelleher, Othon Iliopoulos, Paulo Alexandre da Costa Gameiro Guerreiro
  • Patent number: 10006065
    Abstract: Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: June 26, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Syed Hussain Imam Abidi
  • Patent number: 9994876
    Abstract: The invention relates to recombinant cells and their use in the production of ethylene glycol.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: June 12, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Brian Pereira, Marjan De Mey, Deepak Dugar, Jose Luis Avalos
  • Patent number: 9957527
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: May 1, 2018
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Publication number: 20180080035
    Abstract: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
    Type: Application
    Filed: September 28, 2017
    Publication date: March 22, 2018
    Applicants: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Patent number: 9879248
    Abstract: The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: January 30, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai
  • Patent number: 9862977
    Abstract: Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: January 9, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai, Sagar Chakraborty