Patents by Inventor Gregory Stephanopoulos

Gregory Stephanopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing lactic acid from organic waste
    Patent number: 10174347
    Abstract: Aspects of the invention relate to methods for producing lactic acid from organic waste, comprising contacting organic waste with a microbial community to form a fermentation mixture, and fermenting the fermentation mixture under controlled pH and temperature conditions for a time sufficient to produce lactic acid.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: January 8, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Devin Hedley Currie, Kristen Jean Fortnam
  • MICROBIAL ENGINEERING FOR THE PRODUCTION OF CHEMICAL AND PHARMACEUTICAL PRODUCTS FROM THE ISOPRENOID PATHWAY
    Publication number: 20180282766
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Application
    Filed: March 19, 2018
    Publication date: October 4, 2018
    Applicants: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Metabolic gene, enzyme, and flux targets for cancer therapy
    Patent number: 10064885
    Abstract: A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1, isocitrate dehydrogenase 2 (IDH2), aconitase 1 (ACO1), aconitase 2 (ACO2), glutaminase (GLS), glutamate dehydrogenase (GDH) and transaminase, provides effective means of inhibiting tumor growth.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: September 4, 2018
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Gregory Stephanopoulos, Christian M. Metallo, Joanne K. Kelleher, Othon Iliopoulos, Paulo Alexandre da Costa Gameiro Guerreiro
  • Microbial engineering for the production of fatty acids and fatty acid derivatives
    Patent number: 10006065
    Abstract: Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: June 26, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Syed Hussain Imam Abidi
  • Engineering microbes and metabolic pathways for the production of ethylene glycol
    Patent number: 9994876
    Abstract: The invention relates to recombinant cells and their use in the production of ethylene glycol.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: June 12, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Brian Pereira, Marjan De Mey, Deepak Dugar, Jose Luis Avalos
  • Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
    Patent number: 9957527
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: May 1, 2018
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • MICROBIAL ENGINEERING FOR THE PRODUCTION OF CHEMICAL AND PHARMACEUTICAL PRODUCTS FROM THE ISOPRENOID PATHWAY
    Publication number: 20180080035
    Abstract: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
    Type: Application
    Filed: September 28, 2017
    Publication date: March 22, 2018
    Applicants: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Engineered microbes and methods for microbial oil overproduction from cellulosic materials
    Patent number: 9879248
    Abstract: The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: January 30, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai
  • Engineered microbes and methods for microbial oil production
    Patent number: 9862977
    Abstract: Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: January 9, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai, Sagar Chakraborty
  • Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
    Patent number: 9796980
    Abstract: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: October 24, 2017
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • STRAIN AND BIOPROCESS ENGINEERING FOR HIGH LIPID PRODUCTION
    Publication number: 20170183670
    Abstract: Some aspects provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. Such engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
    Type: Application
    Filed: October 18, 2016
    Publication date: June 29, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: GREGORY STEPHANOPOULOS, Kangjian Qiao, Peng Xu
  • MICROBIAL PRODUCTION OF RENEWABLE GLYCOLATE
    Publication number: 20170121717
    Abstract: Some aspects provide engineered microbes for glycolate production. Methods for microbe engineering and culturing are also provided herein. Such engineered microbes exhibit greatly enhanced capabilities for glycolate production.
    Type: Application
    Filed: September 30, 2016
    Publication date: May 4, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: GREGORY STEPHANOPOULOS, Zheng-Jun Li, Brian Pereira
  • MICROBIAL ENGINEERING FOR THE PRODUCTION OF CHEMICAL AND PHARMACEUTICAL PRODUCTS FROM THE ISOPRENOID PATHWAY
    Publication number: 20170002382
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Application
    Filed: July 12, 2016
    Publication date: January 5, 2017
    Applicants: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • MICROBIAL ENGINEERING FOR THE PRODUCTION OF CHEMICAL AND PHARMACEUTICAL PRODUCTS FROM THE ISOPRENOID PATHWAY
    Publication number: 20170002366
    Abstract: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
    Type: Application
    Filed: May 12, 2016
    Publication date: January 5, 2017
    Applicants: Massachusetts Institute of Technology, National University of Singapore
    Inventors: PARAYIL K. AJIKUMAR, Gregory Stephanopoulos, Heng Phon Too
  • METHODS FOR CONVERSION OF FOOD WASTE TO CHEMICAL PRODUCTS
    Publication number: 20160355849
    Abstract: Aspects of the invention relate to methods for producing lactic acid from organic waste, comprising contacting organic waste with a microbial community to form a fermentation mixture, and fermenting the fermentation mixture under controlled pH and temperature conditions for a time sufficient to produce lactic acid.
    Type: Application
    Filed: April 29, 2016
    Publication date: December 8, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Devin Hedley Currie, Kristen Jean Fortnam
  • METABOLIC FLUX BIOSENSOR
    Publication number: 20160326535
    Abstract: Metabolic flux biosensors are provided herein, as are related compositions and methods useful for, inter alia, identifying factors which increase the production of metabolites and/or end products of metabolic pathways, and for the production of inter alia, metabolites and/or end products of metabolic pathways.
    Type: Application
    Filed: January 8, 2015
    Publication date: November 10, 2016
    Applicants: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
    Inventors: Jose Luis Avalos, Gerald Fink, Gregory Stephanopoulos
  • Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
    Patent number: 9404130
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: August 2, 2016
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL OVERPRODUCTION FROM CELLULOSIC MATERIALS
    Publication number: 20160186163
    Abstract: The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
    Type: Application
    Filed: August 4, 2015
    Publication date: June 30, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai
  • Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
    Patent number: 9359624
    Abstract: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: June 7, 2016
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • ENGINEERING MICROBES AND METABOLIC PATHWAYS FOR THE PRODUCTION OF ETHYLENE GLYCOL
    Publication number: 20160076061
    Abstract: The invention relates to recombinant cells and their use in the production of ethylene glycol.
    Type: Application
    Filed: September 24, 2015
    Publication date: March 17, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Brian Pereira, Marjan De Mey, Deepak Dugar, Jose Luis Avalos