Abstract: A wearable medical monitoring (WMM) system may be worn for a long time. Some embodiments of WMM systems are wearable cardioverter defibrillator (WCD) systems. In such systems, ECG electrodes sense an ECG signal of the patient, and store it over the long-term. The stored ECG signal can be analyzed for helping long-term heart rate monitoring of the patient. The heart rate monitoring can be assisted a) by special filtering techniques that remove short-term variations inherent in patients' short-term heart rate determinations, and b) by indication techniques that indicate when conditions hampered sensing of the ECG signal too much for a reliable heart rate determination.

Abstract: A system and method for treating critical limb ischemia (CLI) including a radiopaque micro stent disposed for cross ankle stenting as well as retrograde pedal/tibial artery access, in conjunction with antegrade access for the recanalization of impaired tibial vessels. A radiopaque medical device is constructed from a tubular-shaped body having a thin wall defining a specific strut pattern. In an additional aspect, the present apparatus introduces a new radiopaque medical device, such as a stent, wherein the tubular body includes a super elastic, nickel-titanium (nitinol) alloy.

Abstract: Systems, methods and accompanying apparatuses to treat critical limb ischemia through the superficial femoral arteries utilizing a specifically designed delivery package for entry proximal to area above the ankle with the capability to antegrade access via PT or AT into ankle and foot and retrograde access via pedal or plantar arch into the dorsalis pedis artery (DP).

Abstract: A stent delivery system, which includes a catheter and a stent stabilizer and pusher mechanism to capture and deploy a braided stent. The stabilizer pusher mechanism has a reinforced polymer shaft with two ends, a hub, a marker band and a braided mesh sock. The stent stabilizer and pusher mechanism further possesses a reinforced polymer shaft, which is constructed to have a low friction lumen. The low friction lumen may be guide wire compatible.

Abstract: A system and accompanying methods for treating a blockage of the superior femoral artery including utilization of a puncture insertion mechanism, an introducer sheath, a guide catheter and an expandable device. Entry into the body is established through the popliteal and advancing retrograde through the popliteal artery toward the lower superior femoral artery region and in some embodiments utilizing an introducer sheath, a guide catheter and a balloon are featured.

Abstract: A medical device such as a catheter may have an elongate shaft that includes a hypotube having a cut formed therein. The elongate shaft may define a lumen that extends within the elongate shaft. A polymer may be disposed over at least a portion of the hypotube. A medical device may include a cut hypotube having a constant pitch and may be configured to reversibly and temporarily alter the pitch of at least a portion of the cut hypotube. In some cases, the medical device may be configured to reversibly and/or temporarily alter a compressive strength of at least a portion of the cut hypotube.

Abstract: The present invention is directed to a pharmaceutical composition that includes a combination of about 2-5 milligrams of a non-steroidal anti-inflammatory drug and from about 2-30 milligrams of an opioid analgesic in a single pharmaceutical dosage unit that can provide effective chronic pain management with the added benefit of reduced side effects such as withdrawal and gastrointestinal disorders. The non-steroidal anti-inflammatory drug may be piroxicam and the opioid analgesic may be buprenorphine. The present invention also provides for a method of managing pain in a patient that includes administering the pharmaceutical composition previously described. The pharmaceutical composition previously described may be administered in a single or multiple dosage regimen.

Abstract: The present invention is directed to a pharmaceutical composition that includes a combination of about 2-5 milligrams of a non-steroidal anti-inflammatory drug and from about 2-30 milligrams of an opioid analgesic in a single pharmaceutical dosage unit that can provide effective chronic pain management with the added benefit of reduced side effects such as withdrawal and gastrointestinal disorders. The non-steroidal anti-inflammatory drug may be piroxicam and the opioid analgesic may be buprenorphine. The present invention also provides for a method of managing pain in a patient that includes administering the pharmaceutical composition previously described. The pharmaceutical composition previously described may be administered in a single or multiple dosage regimen.

Abstract: The present invention is directed to a pharmaceutical composition that includes a combination of about 2-5 milligrams of a non-steroidal anti-inflammatory drug and from about 2-30 milligrams of an opioid analgesic in a single pharmaceutical dosage unit that can provide effective chronic pain management with the added benefit of reduced side effects such as withdrawal and gastrointestinal disorders. The non-steroidal anti-inflammatory drug may be piroxicam and the opioid analgesic may be buprenorphine. The present invention also provides for a method of managing pain in a patient that includes administering the pharmaceutical composition previously described. The pharmaceutical composition previously described may be administered in a single or multiple dosage regimens.

Abstract: The system and method for protecting multiple networked enclaves each having one or more insecure machines. The system may include an attack detector as part of a secure node (e.g., SAFE node) proxy. The system may include an attack detector external to the proxy. The proxy may support multiple detectors and its actions may include isolating an insecure machine, cleansing an insecure machine, or tattling on (impugning the reputation of) an insecure machine.

Abstract: A coil-reinforced medical device delivery mechanism including a stiff proximal end for enhanced pushability and a soft distal end, including a free floating tip portion, for increased maneuverability and decreased breakage. The system utilizes a non-compliant balloon mounted on a flexible, single lumen shaft device with a support mandrel construction.

Abstract: A stent delivery system, which includes a catheter and a stent stabilizer and pusher mechanism to capture and deploy a braided stent. The stabilizer pusher mechanism has a reinforced polymer shaft with two ends, a hub, a marker band and a braided mesh sock. The stent stabilizer and pusher mechanism further possesses a reinforced polymer shaft, which is constructed to have a low friction lumen. The low friction lumen may be guide wire compatible.

Abstract: A system and method for treating critical limb ischemia (CLI) including a radiopaque micro stent disposed for cross ankle stenting as well as retrograde pedal/tibial artery access, in conjunction with antegrade access for the recanalization of impaired tibial vessels. A radiopaque medical device is constructed from a tubular-shaped body having a thin wall defining a specific strut pattern. In an additional aspect, the present apparatus introduces a new radiopaque medical device, such as a stent, wherein the tubular body includes a super elastic, nickel-titanium (nitinol) alloy.

Abstract: A medical device such as a catheter may have an elongate shaft that includes a hypotube having a cut formed therein. The elongate shaft may define a lumen that extends within the elongate shaft. A polymer may be disposed over at least a portion of the hypotube. A medical device may include a cut hypotube having a constant pitch and may be configured to reversibly and temporarily alter the pitch of at least a portion of the cut hypotube. In some cases, the medical device may be configured to reversibly and/or temporarily alter a compressive strength of at least a portion of the cut hypotube.

Abstract: The system and method for protecting multiple networked enclaves each having one or more insecure machines. The system may include an attack detector as part of a secure node (e.g., SAFE node) proxy. The system may include an attack detector external to the proxy. The proxy may support multiple detectors and its actions may include isolating an insecure machine, cleansing an insecure machine, or tattling on (impugning the reputation of) an insecure machine.

Abstract: The present invention provides a method of determining whether a subject is afflicted with a depressive disorder comprising: (i) introducing into the subject a positron emission tomography (PET) radioligand capable of binding with a serotonin 5-HT1A receptor; (ii) performing one or more PET scans of the subject; (iii) determining, by analysis of the one or more PET images, a receptor binding potential of the PET radioligand for the serotonin 5-HT1A receptor in a region of interest in the subject; (iv) comparing the receptor binding potential value of the PET radioligand in the region of interest in the subject to a predetermined receptor binding potential threshold value; and (v) classifying the subject as having the depressive disorder or as not having the depressive disorder based on the comparison of step (iv), thereby determining whether the subject is afflicted with the depressive disorder.

Abstract: A coil-reinforced medical device delivery mechanism including a stiff proximal end for enhanced pushability and a soft distal end, including a free floating tip portion, for increased maneuverability and decreased breakage. The system utilizes a non-compliant balloon mounted on a flexible, single lumen shaft device with a support mandrel construction.

Abstract: In some embodiments, the present invention may be directed to various pharmaceutical dosage units comprising at least one opioid analgesic in combination with a benzodiazepine blocker. In some embodiments, the present invention may be directed to various methods of treatment using such pharmaceutical dosage units. In some embodiments, these pharmaceutical dosage units may be used for treating: pain, chronic pain, sub-acute pain, chronic and sub-acute pain, anxiety, addiction in general, opiate addiction, and benzodiazepine addiction, opiate and benzodiazepine addiction; opiate dependence, benzodiazepine dependence; and for reducing a likelihood of overdose associated with concomitant use of opiates with benzodiazepines, and for mitigating against drug diversion.

Abstract: A filtration system to collect debris in the vascular system and/or other systems and a method for using such filter. An internally disposed apparatus for inside a fluid conduit during a medical procedure which includes a filtering membrane and a frame connected to the membrane. In one embodiment of the filtration system, a filter may generally include a membrane, a frame, and a rod.

Abstract: The present disclosure includes a method comprising positioning a nose of a rodent within a nose chamber of a device for anesthetizing the rodent, the nose chamber configured to partially enclose an anesthetizing gas and hold the nose of the rodent in contact with the anesthetizing gas, delivering a positive flow of the anesthetizing gas into the nose chamber through a gas intake channel sufficient to anesthetize the rodent, supplying a waste gas reservoir to collect the anesthetizing gas, the waste gas reservoir in communication with the nose chamber through a gas transport channel and coupled with the nose chamber in an open configuration allowing the anesthetizing gas and ambient air to flow into the waste gas reservoir, and actively retrieving the anesthetizing gas and ambient air from the waste gas reservoir with a negative flow conveyed through a gas outtake channel in communication with the waste gas reservoir.