Abstract: According to at least one aspect, embodiments of the invention provide a 3D printer comprising an anisotropic head that solidifies, along anisotropic toolpaths, fiber swaths having an anisotropic characteristic oriented relative to a trajectory of the anisotropic tool paths, an isotropic head that solidifies, along isotropic toolpaths, a substantially isotropic material, a motorized drive for moving the anisotropic head and a build plate supporting a printed part in at least three degrees of freedom, and a controller configured to control the 3D printer to build the printed part by solidifying the isotropic material along the isotropic tool paths, solidifying the anisotropic material in fiber swaths tracking a non-concentric set of anisotropic tool paths for at least a first sequence of parallel shells, solidifying the anisotropic material in fiber swaths tracking an outer concentric set of anisotropic tool paths for at least a second sequence of parallel shells.

Abstract: An edge coupon for an airfoil is provided. The coupon includes: a coupon body including: a coolant feed; an outward leg extending toward an edge of the coupon and fluidly coupled to the coolant feed; a return leg extending away from the edge of the coupon and radially offset from the outward leg along a radial axis of the coupon; a turn for fluidly coupling the outward leg and the return leg; a collection passage fluidly coupled to the return leg; and a coupling region configured to mate with an airfoil body of the airfoil.

Abstract: Disclosed are methods and apparatus for using an audible signal to monitor conditions at a downhole location in a well through use of a well cable containing a fiber optic, which may be either a slickline or a wireline fiber-optic cable, and providing an audible signal which varies in response to the monitored condition. The condition monitored can be strain in the fiber optic well cable, which can be sensed in one or more locations in the fiber optic well cable, in many examples through use of a sensor such as a Bragg grating associated with or formed in an optical fiber within the well cable. In some examples, a temperature measurement may be used to compensate for temperature effects impacting the strain measurement.

Abstract: In molten metal jetting, where droplets of metal are jetted to 3D print a part, each layer may be traversed each successive layer with a normalizing grinding wheel or other leveling device such as a layer to level each successive layer, and/or the melt reservoir or printing chamber may be filled with an anoxic gas mix to prevent oxidation.

Abstract: An example valve section includes: a valve body configured to be fluidly coupled to the source and the actuator; a spool movable in the valve body intermediate the source and the actuator; a pressure compensator valve disposed upstream from the spool and configured to regulate flow received from the source, where the valve body defines (i) a first passage disposed upstream from the spool and configured to fluidly couple the pressure compensator valve to the spool, and (ii) a second passage disposed downstream from the spool and configured to fluidly couple the spool to the actuator; and a counterbalance valve disposed in the second passage downstream from the spool, where the counterbalance valve is opened to permit flow therethrough from the actuator to the spool in response to a pilot pressure derived from the first passage when the spool is shifted from a neutral position.

Abstract: According to one aspect, embodiments herein provide a method of reducing distortion in an additively manufactured part comprising forming a shrinking platform from a composite including metal particles embedded in a first matrix, forming shrinking supports from the composite, forming a part from the composite upon the shrinking platform and shrinking supports, forming an interior structure in at least one of the shrinking platform, the shrinking supports, and the part having a plurality of chambers with interconnections therebetween, forming from the shrinking platform, the sintering supports, and the part a portable assembly, and debinding the first matrix in the portable assembly to form a portable assembly in a brown state, wherein debinding the first matrix includes penetrating a fluid debinder into the interior structure of the at least one of the shrinking platform, the shrinking supports, and the part to debind the first matrix from within the interior structure.

Abstract: In accordance with some embodiments of the present disclosure, a shape memory alloy rope socket for a downhole tool is disclosed. The rope socket includes a coupler formed of a shape memory alloy. The rope socket further includes a housing surrounding the coupler. The housing including a pathway and a connector for attaching a downhole tool is attached. The rope socket further includes a line passing through the pathway and the coupler such that the coupler is in contact with the line along a length of the coupler when the coupler is in a reduced diameter state.

Abstract: A blade includes an airfoil defined by a pressure side outer wall and a suction side outer wall connecting along leading and trailing edges and form a radially extending chamber for receiving a coolant flow. A rib configuration may include: a leading edge transverse rib connecting the pressure side outer wall and the suction side outer wall and partitioning the radially extending chamber into a leading edge passage within the leading edge of the airfoil and a central passage adjacent to the leading edge passage. One or both camber line ribs connect to a corresponding pressure side outer wall and suction side outer wall at a point aft of the leading edge transverse rib causing the central passage to extend towards one or both of the pressure side outer wall and the suction side outer wall, resulting in a flared center cavity aft of the leading edge.

Abstract: A method comprising depositing, in layers, a shrinking platform formed from a composite including metal particles embedded in a first matrix, depositing shrinking supports of the composite upon the shrinking platform, forming a separation clearance dividing at least one shrinking support into fragments, depositing, from the composite, a part upon the shrinking platform and shrinking supports, depositing a separation material intervening between the part and the shrinking supports, the separation material including a ceramic powder and a second matrix, and forming, from the shrinking platform, shrinking supports, separation material, and part, a portable platform assembly in a green state, wherein the shrinking support is configured to prevent the portable platform assembly from distorting from gravitational force during sintering of the metal particles of the assembly in a brown state, and wherein the ceramic powder of the separation material is configured to separate the shrinking support from the part follo

Abstract: The present invention provides novel hepcidin analogues, and related methods of using these hepcidin analogues to treat or prevent a variety of diseases and disorders, including iron overload diseases such as hereditary hemochromatosis, iron-loading anemias, and other conditions and disorders described herein.

Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Abstract: In molten metal jetting, where droplets of metal are jetted to 3D print a part, each layer may be traversed each successive layer with a normalizing grinding wheel or other leveling device such as a layer to level each successive layer, and/or the melt reservoir or printing chamber may be filled with an anoxic gas mix to prevent oxidation.

Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.

Abstract: Liquid detergent composition that includes a surfactant system and encapsulates. Methods for making and using such detergents.

Abstract: In accordance with embodiments of the present disclosure, a cable system for conveying well servicing equipment into a wellbore includes a core support structure extending longitudinally along an axis of the cable system. The core support structure comprises polymer reinforced with fibers, and the fibers are oriented substantially parallel to the axis of the cable system. The cable system also includes a mesh layer disposed around and bonded to the core support structure. The mesh layer includes metal wrapped around the core support structure. The cable system also includes a polymeric coating disposed around and bonded to the mesh layer. The mesh layer enables increased structural support of the cable system, particularly against forces in the radial direction relative to the axis of the cable system. In some applications, the mesh layer acts as a return conductive path for conductors embedded in the core support structure.

Abstract: A vehicle console includes a housing having an interior volume. A console bin is disposed within the interior volume. The console bin is an injection molded member having a base and a plurality of bin walls coupled to the base at living hinges, wherein the plurality of bin walls form an interior surface that extends orthogonally from the base.

Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.

Abstract: A turbine airfoil for a rotating blade or stationary nozzle vane includes an airfoil body including a leading edge and a trailing edge. A coolant supply passage extends within the airfoil body and a coolant return passage extends within the airfoil body, with each passage having respective a supply and return connection passage to an exterior surface of the airfoil body. A seat in the exterior surface of the airfoil body receives a cover that includes a trench on an interior surface thereof to fluidly connect the return connection passage and the supply connection passage and form a coolant passage for the airfoil body. Various arrangements of cooling circuits may be created with the cover that allow for reuse of the coolant.

Abstract: Successive layers of a wall of a part are deposited to form a first access channel extending from an exterior of the part to an interior of the part, as well as to form a distribution channel connecting an interior volume of the honeycomb infill to the first access channel. A binder matrix retaining sinterable powder is debound by flowing a debinding fluid through the first access channel and the distribution channel within the interior volume of the honeycomb infill.