Abstract: An apparatus, including a drone which is assigned to a venue and programmed or configured for flight, navigation, or operation, within an interior of the venue. The drone is activated upon an occurrence of a drone activation event, and the drone flies or navigates inside the venue in response to the drone activation event. The drone finds or locates an individual or an animal inside the venue, and initiates a communication link with a communication device, wherein the communication device is located at a location remote from the venue. An audio recording device or a video recording device of or at the drone records audio information or video information, and the drone transmits the audio information or the video information to the communication device or to a computer. The computer is located at a location remote from the venue. The drone provides audio information via a speaker.

Abstract: A surgical clip applier includes a handle assembly, an elongated shaft, a drive shaft, a cam pin, and an end effector. The cam pin is disposed in mechanical cooperation with the drive shaft. The end effector is disposed adjacent a distal end of the elongated shaft and includes a first jaw member and a second jaw member. The end effector is disposed in operative engagement with the drive shaft such that longitudinal translation of the drive shaft relative to the housing of the handle assembly causes the first jaw member to move toward the second jaw member. The first jaw member includes a first cam slot configured to slidingly receive the cam pin. The first cam slot defines a first portion having a first slope and a second portion having second slope.

Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.

Abstract: According to one aspect, embodiments herein provide a furnace for debinding and sintering additively manufactured parts comprising a unitarily formed retort having at least one open side, a heater for heating a sintering volume within the retort to a debinding temperature and to a sintering temperature, an end cap sealing the at least one open side, a forming gas line penetrating the end cap for supplying forming gas at a flowrate, and a heat exchanger within the retort, outside the sintering volume, and adjacent a heated wall of the retort, the heat exchanger having an inlet connected to the forming gas line and an outlet to the sintering volume, wherein the heat exchanger includes a heat exchange tube length sufficient to heat the forming gas to within 20 degrees Celsius of the sintering temperature before the forming gas exits the outlet.

Abstract: Methods are provided for determining liver function based on a Compartmental Model (CM) method for analysis of cholate SHUNT test data which closely approximates and elucidates the underlying physiology of hepatic uptake of cholate from systemic and portal circulations simultaneously.

Abstract: The systems and methods described herein allow users to control access to regulated data of the user (stored in a secured third party database) through interaction on a mobile device (or other computing device), such as to provide a touch gesture on the mobile device that causes the users regulated data to be accessible to a third party. The regulated data may include credit data of the user, such as a credit report or credit file. Access rights to the regulated data may be provided in real-time (or near real-time) in response to a request for the data from a third party, for example. The system may allow a user to respond to an alert or notification that is automatically sent to the computing device of the user in response to a request for a secure regulated data of the user.

Abstract: An electrified powertrain system for a vehicle is provided that integrates the electric machine(s) as part of the sprung mass of the vehicle, i.e., vehicle components that are supported on the suspension system, such as a unibody arrangement or a body-on-frame arrangement.

Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.

Abstract: Apparatus, methods, and systems are provided to count one or more magnetically permeable objects that have passed by a magnetic sensor and determine a direction thereof. The apparatus comprises a first permanent magnet; a second permanent magnet; a magnetic field sensor disposed between opposing poles of the first permanent magnet and the second permanent magnet; and a circuit connected to the magnetic field sensor, the circuit configured to count one or more magnetically permeable objects that have passed by the magnetic field sensor, and determine direction of the one or more magnetically permeable objects based on an output of the magnetic field sensor.

Abstract: The disclosure provides compositions and methods for the treatment and/or prevention of sickle cell disease.

Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.

Abstract: A device includes an access cannula, a puncturing element, a handle. The access cannula includes a lumen extending therethrough. The access cannula is sized and shaped to extend through an endoscopic shaft to a target tissue within a living body. The puncturing element is sized and shaped to extend through the lumen of the access cannula and distally out a distal end of the access cannula. The handle includes a handle body and a mechanism for advancing the access cannula from a proximal position relative to the puncturing element, where a puncturing tip of the puncturing element is exposed distal to a distal end of the access cannula, to a distal position relative to the puncturing element, where the distal end of the access cannula covers the puncturing tip of the puncturing element.

Abstract: Provided are ulinastatin glycoforms, ulinastatin fusion polypeptides, and related compositions, mixtures, and methods of use, including methods of recombinantly producing ulinastatin polypeptides and treating diseases.

Abstract: Methods and systems for controlling window arrangements for tabbed user interface elements. An example method includes displaying a plurality of application windows including at least one application window for a web browser application having multiple open tabs, the multiple open tabs including at least one active tab and multiple inactive tabs, receiving an input to invoke a snap assist mode; in response to the input, display a snap assist user interface to reconfigure the display of one or more the plurality of the application windows, the snap assist user interface including tab representations and an application-window representation. In response to receiving a selection of a tab representation, a web browser application window is displayed with the corresponding tab as the active tab.

Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.

Abstract: In one aspect of the present disclosure, a device may include a shaft having a distal end, and a tip at the distal end of the shaft. The tip may include an opening defined by a surface of the tip. An instrument inserted through the shaft may extend distally out of the opening. The device also may include an elevator for engaging the instrument. The elevator may include a proximal end fixed relative to the surface of the tip, a proximal portion extending distally from the proximal end, and a distal portion extending distally from the proximal portion. A force exerted on the elevator bends the proximal portion to deflect the distal portion without bending of the distal portion.

Abstract: An apparatus, including a power management computer; a fuel intake device which collects or recovers a fuel; a fuel storage device which stores the fuel; an electrical power generator which generates electrical power from or with the fuel; a power storage device or power pass-through system; and an electrical power supply system which provides at least some of the electrical power to a vehicle or premises, a public electrical energy grid, a private electrical energy grid, or a blockchain mining or transaction processing computer, or which recharges a battery of a stationary or moving vehicle; and a meter which records information regarding an amount or quantity of electrical power provided by the electrical power supply system. The power management computer processes information regarding the amount or quantity of the electrical power provided. Information regarding the electrical power provided is stored in a distributed ledger and blockchain technology system.

Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.

Abstract: A sensing apparatus in the present disclosure is configured to measure magnetic flux of a magnetic field generated by a magnetic source and flowing through a sample slurry to determine magnetic permeability of the sample slurry. The sensing apparatus comprises a magnetic sensor inside a sensor housing that measures magnetic flux through a sensor housing made of a ferromagnetic material. The magnetic sensor sends measurements of the magnetic flux to a computing device that determines the presence of cementing fluids in the slurry based on the magnetic flux measurements.

Abstract: A laminoplasty implant system includes a spacer implant configured for insertion into an interlaminal space defined by a cut into a lamina of a vertebra. The spacer implant includes a first end and a second end, and a tunnel extending axially between the first end and the second end. The laminoplasty implant system also includes a single fastener implant configured for insertion through the tunnel when the spacer implant is inserted into the interlaminal space. The fastener implant includes a head and a fastener portion. The head is configured to abut against a portion of the spacer implant and to extend axially from the first end into the lamina of the vertebra. The fastener portion is configured to extend through the tunnel and to extend axially from the second end into a lateral mass of the vertebra.