Abstract: The present invention provides hepcidin analogues, and related pharmaceutical compositions and use thereof in treating polycythemia vera.

Abstract: Various embodiments related to three dimensional printers, and reinforced filaments, and their methods of use are described. In one embodiment, a void free reinforced filament is fed into an conduit nozzle. The reinforced filament includes a core, which may be continuous or semi-continuous, and a matrix material surrounding the core. The reinforced filament is heated to a temperature greater than a melting temperature of the matrix material and less than a melting temperature of the core prior to drag the filament from the conduit nozzle.

Abstract: A drive system for a drug delivery system includes a pressure chamber, a primary container, and a pressurized fluid. The pressure chamber has an outer surface and an inner surface that defines an interior volume. The primary container also has an outer surface and an inner surface that defines an interior volume to store a medicament to be administered to a user. The primary container is at least partially disposed within the interior volume of the pressure chamber. The pressurized fluid is disposed in the interior volume of the pressure chamber and is pressurized to exert a pressure on at least a portion of the outer surface of the primary container.

Abstract: An apparatus, including cameras, microphone, speaker, processor, display, touchscreen keyboard, global positioning system, and collision avoidance sensor. Upon detecting a texting, e-mail, operational mode, game or gaming operational mode, or speakerphone, operational mode, the processor activates a camera and the collision avoidance sensor. The display displays a view in front of, or an anticipated travel path of movement of, the apparatus. The processor monitors a location of the apparatus. If the apparatus is outside of the safe area of travel, the processor activates the camera or a second camera to record a picture or video at the apparatus. The processor generates a notification message containing the picture or the video or containing a link to the picture or the video. The apparatus transmits the notification message to a communication device associated with an authorized individual or law enforcement personnel.

Abstract: A base station antenna includes a remote electronic tilt (“RET”) actuator, a phase shifter having a moveable element and a mechanical linkage extending between the RET actuator and the phase shifter. The mechanical linkage includes an adjustable RET linkage that has a first link that has a first connection element, a second link that has a second connection element and a connecting member that includes at least a third link. The adjustable RET linkage includes at least a first hinge and a second hinge.

Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.

Abstract: A method of making a translucent cleaning composition is disclosed. The method includes providing a perfume; providing a hydrogen bond receiving compound; providing a hydrogen bond providing compound; combining the hydrogen bond receiving compound with the hydrogen bond providing compound to create a eutectic liquid; adding the perfume to the eutectic liquid to create a perfumed eutectic liquid; and adjusting the pH of the perfumed eutectic liquid to above 6.0.

Abstract: An apparatus includes a sub-surface safety valve (SSSV) to be positioned in a wellbore. The SSSV is configurable to move between a closed position and an open position. While in the closed position, the SSSV prevents downhole fluid in the wellbore to flow to a surface of the wellbore. While in the open position, the SSSV allows the downhole fluid in the wellbore to flow to the surface of the wellbore. The apparatus further includes an electrostatic motor to be positioned in the wellbore and to be coupled to the SSSV. The electrostatic motor is to be selectively powered to move the SSSV between the closed position and the open position.

Abstract: A system for adding weight and clamping a bar, as non-exclusive example, a barbell collar, includes a weighted collar attachable to a clamp. The clamp may include configurations that mate with the weighted collar, for selectively retaining and removing the weighted collar from mate with the clamp.

Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.

Abstract: Disclosed are compounds, methods, compositions, and kits that allow for treating cancer by, e.g., targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, or lymphoma. In some embodiments, the cancer is liver cancer, endometrial cancer, leukemia, or multiple myeloma.

Abstract: Compacted fibrous structure articles and methods for making the same are provided.

Abstract: A method of operating a particulate matter sensor having a pair of spaced apart electrodes and a heater includes accumulating particulate matter on the sensor, thereby changing resistance between the pair of spaced apart electrodes. The particulate matter sensor includes a sensing cycle that includes a deadband zone, followed by an active zone, which is followed by a regeneration zone in which the heater is operated to elevate the temperature of the particulate matter sensor to a first predetermined temperature for a first predetermined time in order to oxidize the particulate matter accumulated on the particulate matter sensor. The method also includes interrupting the sensing cycle with a modified regeneration zone which is either higher in temperature or length than the regeneration zone.

Abstract: Systems and methods for wireless downhole positioning are provided. The method can include synchronizing a first clock with a second clock, wherein the first clock is disposed in a first transmitter, wherein the first transmitter is disposed at a known location, and wherein the second clock is disposed in a downhole tool. The method can further include disposing the downhole tool into a wellbore, wherein the downhole tool comprises a first receiver; transmitting a first wireless signal from the first transmitter along the wellbore at first time; receiving the first wireless signal via the first receiver at a second time; determining a first elapsed time between the first time and the second time; and determining a first downhole position of the downhole tool based on the first elapsed time.

Abstract: A method for enabling cloud-based management services using an on-site management cloud engine includes establishing a single secure communication channel between a management cloud engine (MCE) located in a customer premises and a cloud management services platform located in a cloud computing infrastructure, receiving, by the MCE from a unified management service (UMS) manager located in the cloud management services platform, a management instruction message directed to at least one network function located in the customer premises via the single secure communication channel, converting instruction data contained in the management instruction message to a legacy protocol recognized by the at least one network function, and providing the converted instruction data to the at least one network function.

Abstract: A drug delivery device including a housing, a drug storage container, and a removable cap is provided. The housing includes a housing camming feature and a longitudinal axis and includes an opening. The drug storage container includes a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The removable cap defines a cap camming feature and is configured to be removably coupled with the housing such that the removable cap has a storage position where the removable cap is coupled with the housing and at least partially covering the opening and a removed position where the removable cap is not coupled with the housing. The cap camming feature and the housing camming feature are configured to translate rotational motion into axial motion such that, upon rotational movement of the removable cap, the cap camming feature and/or the housing camming feature urge the removable cap along the longitudinal axis.

Abstract: A drug delivery device including a housing, a drug storage container, and a removable cap is provided. The removable cap may be configured to be removably coupled with the housing such that the removable cap has a storage position where the removable cap is coupled with the housing and at least partially covering an opening in the housing and a removed position where the removable cap is not coupled with the housing. The removable cap may include an outer portion, an inner portion, and a gap separating at least a portion of the inner portion and at least a portion of the outer portion such that the at least a portion of the outer portion is allowed to bend with respect to the at least a portion of the inner portion if the at least a portion of the outer portion is subjected to an external force.

Abstract: A multifunctional assembly having a resistive element a conductive element in electrical communication with the resistive element, the conductive element defining at least one of a plurality of multifunctional zones of the resistive element, wherein the conductive element is configured to direct a flow of electricity across at least one of the plurality of multifunctional zones of the resistive element in a preselected manner.

Abstract: A lid for closing an open ended blood chamber is provided. The lid is a one piece device forming an inlet to the blood chamber. The one piece device includes a filter media spaced apart from the inlet and wherein blood passing through the inlet passes through the filter media upon entry into the blood chamber. The filter media filters gross particulate from the blood passing therethrough. The one piece device further includes a vent port with an associated vent port cover to allow air separated to vent from the blood chamber.

Abstract: A semiconductor package includes a semiconductor die including a semiconductor substrate, a strain-sensitive component located within or over a metallization layer of the semiconductor die, wherein a parameter of the strain-sensitive component exhibits a longitudinal shift due to a longitudinal strain and a transverse shift due to a transverse strain, and a mold compound covering the semiconductor die and the strain-sensitive component. The semiconductor package, including the semiconductor die and the mold compound, defines an orthogonal package-induced strain ratio on the strain-sensitive component on the semiconductor die surface. The strain-sensitive component is located such that the longitudinal shift due to package-induced strains offsets the transverse shift due to the package-induced strains.