Abstract: A substituted phenol derivative and a use thereof, are in the field of medicinal chemistry. The substituted phenol derivative is a compound as represented by formula IA, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof, or a deuterated derivative thereof. The derivative not only has sedative, hypnotic and/or anesthetic effects and/or can control status epilepticus, but also has an analgesic effect. The compound can be used in the preparation of a drug that has both an analgesic effect and sedative, hypnotic and/or anesthetic effects and a drug capable of controlling status epilepticus.

Abstract: A bi-level optimization (BLO) method based on a truck mobile charging station (TMCS) leasing mode includes the steps of: establishing a bi-level game model based on a TMCS leasing mode; introducing a Wasserstein distance distributionally robust model based on chance constraints through a distributionally robust optimization (DRO) strategy; balancing economy and robustness of the bi-level game model via the Wasserstein distance distributionally robust model; solving a TMCS operator (TMCO) model through a genetic algorithm (GA) to obtain a revenue-maximizing configuration and a leasing price; and solving a charging facility operator (CFO) two-stage distributionally robust chance-constrained optimization (DRCC) model via a nested column-and-constraint generation (NC&CG) algorithm to obtain a leasing plan and a scheduling strategy with maximum utility. Demands of various operators can be effectively balanced, which can improve the economy of CFOs while ensuring the revenue of TMCOs.

Abstract: A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and/or anesthetic effects, as well as in drugs for controlling status epilepticus.

Abstract: Related to the field of charging infrastructure optimization, a method for online coordinated optimization scheduling of truck mobile charging stations. A two-stage framework is proposed: (1) offline training stage, where a multi-period optimization decision model for TMCSs is constructed, and a look-ahead rolling horizon-value function approximation (LRH-VFA) algorithm is then developed to iteratively learn from historical EV charging data, considering the impact of current-period decisions on future profit; and (2) online scheduling stage, where TMCS scheduling decisions are dynamically updated based on the approximate value function obtained from offline training, along with short-term forecasts and real-time information. The method effectively accounts for the impact of uncertain EV charging demand on TMCS scheduling, dynamically adjusting decisions based on real-time updates.

Abstract: Provided are isolated polynucleotides and polypeptides, and recombinant DNA constructs that are useful for conferring improved drought tolerance and yield in a plant. Also provided are genome edited plants, or plants expressing a recombinant DNA construct, having improved drought tolerance and yield. Further provided are methods for improving drought tolerance and yield by introducing a genome edit in a plant or expressing a recombinant DNA construct in a plant.

Abstract: Provided are suppression DNA constructs and CRISPR/Cas9 DNA constructs that are useful for conferring improved drought tolerance, yield, and/or nitrogen stress tolerance in a plant. Also provided are genome edited plants, or plants expressing a suppression DNA construct, having improved drought tolerance, yield and/nitrogen stress tolerance. Further provided are methods for improving drought tolerance, yield, and/or nitrogen stress tolerance by introducing a genome edit in a plant or expressing a suppression DNA construct in a plant.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring improved drought tolerance and yield. Compositions (such as plants or seeds) comprise these recombinant DNA constructs; and methods utilize these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.

Abstract: Provided are isolated polynucleotides and recombinant DNA constructs encoding polypeptides useful for conferring accelerated or delayed flowering time and/or maturity. Compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs are also provided.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring delayed or accelerated flowering time and maturity. Compositions (such as plants or seeds) comprise these recombinant DNA constructs; and methods utilize these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode late flowering polypeptides.

Abstract: Provided are suppression DNA constructs and CRISPR/Cas9 DNA constructs are useful for conferring improved drought tolerance, yield. Compositions (such as plants or seeds) comprising these constructs; and methods utilize these constructs.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring delayed or accelerated flowering time and/or maturity. Compositions (such as plants or seeds) comprise these recombinant DNA constructs; and methods utilize these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode late flowering polypeptides.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring improved drought tolerance and yield. Compositions (such as plants or seeds) comprise these recombinant DNA constructs; and methods utilize these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring improved drought tolerance and yield. Compositions (such as plants or seeds) comprise these recombinant DNA constructs; and methods utilize these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.

Abstract: Provided are suppression DNA constructs and CRISPR/Cas9 DNA constructs are useful for conferring improved drought tolerance, yield, and/or nitrogen stress tolerance. Compositions (such as plants or seeds) comprising these constructs; and methods utilize these constructs.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring improved drought tolerance. Compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring improved drought tolerance. Compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring improved drought tolerance and yield. Compositions (such as plants or seeds) comprise these recombinant DNA constructs; and methods utilize these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs, suppression DNA constructs and CRISPR/Cas9 DNA constructs are provided. Compositions (such as plants or seeds) with modified expression or activity of the isolated polypeptides are obtained by transforming the regenerable plant cell with a suppression DNA construct or CRISPR/Cas construct. The plants with improving drought tolerance are obtained by decreasing the expression or activity of the isolated polynucleotide.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring improved drought tolerance. Compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs useful for regulating plant heading date or flowering time are provided. Compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs are also provided. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode flowering time-regulating polypeptides.